R Ibarra

Hospital Vozandes

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Disposition kinetics of dibekacin in normal subjects and in patients with renal failure.

PubMed (1987)

A Arancibia J Chávez R Ibarra Irene Ruíz A Icarte

Dibekacin pharmacokinetics was studied in ten healthy volunteers and six patients with renal failure presenting Clcr less than 10 ml X min-1 per 1.73 m2 of body surface, given as a slow intravenous bolus to the volunteers and as a 30-minute intravenous infusion to the patients. The antibiotic was assayed in plasma and urine by means of a microbiological method using Bacillus subtilis. A two-compartment kinetic model was used to describe the bi-phasic decline of the plasma concentration thus establishing the different pharmacokinetic parameters. Elimination parameters beta, k10 and total body clearance were markedly diminished in renal patients (p less than 0.001): t1/2 beta was 2.0 h, k10 = 0.016 min-1 and Cl = 0.87 ml X min-1 kg body weight in normal subjects and t1/2 beta = 21.4 h, k10 = 0.0011 min-1 and Cl = 0.131 ml X min-1 per kg in the patients. Other kinetic parameters, as distribution (alpha) and transfer (k12, k21) constants were lower in patients than in volunteers. Also the different terms of volume of distribution of the two-compartment model (V1, Vdss, Vdarea) were significantly higher in patients than in normal subjects (p less than 0.05). A good correlation (r = 0.987) between patients' beta constant and creatinine clearance was found. A similar relationship between serum creatinine levels and disposition half-life was found (r = 0.955). Urinary recovery at 24 h was 89.0% of the dose given to normals and 15.8% of the dose given to patients.

Intravenous bolus

Elimination rate constant

Bolus (digestion)

Distribution Volume

Source

Cite

Citations (0)

[The kidney in diabetes: study of various pathological and clinical aspects].

PubMed (1974)

Miguel Angel Nadal Juan Abraham Bermúdez Roberto Iotti A A Larguia J E Duhart

Source

Cite

Citations (0)

Lupus eritematoso diseminado

Prensa méd. argent (1970)

O Fustinoni E Sciandro J P Fellner R Ibarra

Source

Cite

Citations (0)

[Morphological and histochemical changes of the ischemic kidney].

PubMed (1966)

Sáenz Ca R Ibarra

Source

Cite

Citations (0)

Evaluation of the high density lipoprotein cholesterol protective effect against atherogenesis in rabbits fed cholesterol supplemented diets.

PubMed (1990)

M. P. Neuman J Neuman H E Mosso R Ibarra Santiago Rodrı́guez

Plasma high density lipoprotein cholesterol (HDL-C) was evaluated in 15 rabbits fed cholesterol supplemented diets to assess its protective effect on the atherogenic process. From a baseline level of 29 +/- 11 mg/dl (mean +/- SD) the maximum attained for HDL-C was twofold in only three rabbits, whereas total cholesterol (TC) increased 20 fold. Plasma TC/HDL-C ratio rose 80 fold from the baseline (2.4 +/- 0.9) and it was the best parameter that correlated with aortic cholesterol accumulation and pathological scores. Aortic TC content increased 10 fold and free cholesterol/cholesterol esters ratio decreased 20 fold. Pathological studies showed that aortic lesion scores rose from 0 to 4. It can be concluded that the high correlations obtained when TC/HDL-C ratio was plotted against both aortic cholesterol deposition and lesion scores, support the theory of the reverse cholesterol transport and the effectiveness of this index to predict the degree of the atherogenic process. On the other hand, the poor response of HDL-C in this model encourages future research using drugs to increase this parameter in order to normalize TC/HDL-C ratio and avoid lesions.

High-density lipoprotein

Reverse cholesterol transport

Source

Cite

Citations (0)

Diálisis en los diabéticos

Diálisis y trasplante: publicación oficial de la Sociedad Española de Diálisis y Trasplante (1981)

Francisco Coronel R Ibarra M.T. García de Lomana C. Muñoz de la Paz P. Horcajo

Source

Cite

Citations (0)

PS186 Conventional Mapping and Ablation of a Lower-Loop Reentrant Atrial Flutter

Global Heart (2016)

R Ibarra Nelson Amores J.L. Laso

Reentrancy

Flutter

10.1016/j.gheart.2016.03.155

Cite

Citations (0)

Familial cardiolaminopathy due to a previously undescribed LMNA gene mutation

EP Europace (2023)

R Ibarra J L Laso Bayas Ana Karina Zambrano

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Cardiolaminopathies are rare genetic alterations, which present diverse mechanical and electrical alterations. OBJECTIVE To present a family carrying an LMNA gene mutation that although not described manifest clinical and electrocardiographic characteristics of the disease. Methods We present the case of two sisters and one brother, aged 65, 57 and 51 years, respectively. At the beginning of their fourth decade, all of them debuted with atrial flutter associated with second and third degree atrioventricular block. Two of them (one or the sisters and the brother) underwent ablation of isthmus-dependent atrial flutter. However, in both, the flutter recurred and no new interventional treatment was further offered. The male subject received a pacemaker implant for treatment of AV block; some years later, he presented a cerebrovascular event and subsequently a recurrence, both while in oral anticoagulation and, actually remains with moderate motor deficit and dysarthria. The youngest woman suffered an embolic cerebrovascular event when she was 50 y/o; she remained asymptomatic in relation to the rhythm disorder and refused a pacemaker. The oldest sister who is asymptomatic, received a pacemaker when she was 45 y/o and now is anticoagulated. By echocardiography, all siblings presented left ejection fraction in between 40 and 50% with decreased strain values and normal left ventricular geometry. Results Recently in our country it is possible to carry out a genetic test, for which the three were subjected to it. In this family, the genetic testing was done using a comercial kit for 172 genes. The result was a Frameshift Indels (non misense) mutation NM_170707.3 c.1526del p.(Pro509LeufsTer39) Exon:9/12, in all three. The caveat is that this LMNA gene mutation has not been previously described. In light of these results, the youngest woman with total AV block and sequelae of cerebrovascular disease and mild left ventricular dysfunction, received an implantable cardiac defibrillator (ICD) implant for primary prevention of sudden death and her siblings are undergoing an upgrade to ICD. Conclusion The mutation found in this family is unique and for the first time reported in the LMNA gene in the world. Genetic diagnosis is limited in our country, which makes it difficult to determine this type of pathology. However, given the clinical presentation of an electrical disorder in all the siblings of a family, in this particular case, it was mandatory to perform this test. These results allow us to better understand the prognosis and intervene appropriately to prevent sudden death, even though there is no treatment to avoid the progression of the disease.

Atrioventricular block

LMNA

Sudden Death

10.1093/europace/euad122.605

Cite

Citations (0)

ACUTE RENAL INSUFFICIENCY OF TOXIC ORIGIN

O Fustinoni D Gotlieb Lancestremere Rg Emilio Freixas R Ibarra

Source

Cite

Citations (0)

Glomerulopatias en el lupus silente

Revista de nefrología, diálisis y transplante (1995)

H Marone R Ibarra R Ocariz A Tortora G Castelli

Source

Cite

Citations (0)