T Onishi

Jikei University School of Medicine

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Fujio Masuda

Kyoto University

T Machida

Nippon Dental University

Yukihiko Ohishi

Yokohama Municipal Minato Red Cross Hospital

H Shirakawa

Nissin Kogyo (Japan)

Yukihiko Oishi

Hitachi (Japan)

Norio Iizuka

Hiroshima University

Gyojiro Nakada

Jikei University School of Medicine

H Goto

Obihiro University of Agriculture and Veterinary Medicine

Takuji Shibahara

Ise Red Cross Hospital

Kazuhiro Abe

Hokkaido University

Cooperative Institutions

Centre Hospitalier Universitaire de Liège

Jikei University School of Medicine

Sorbonne Université

Assistance Publique – Hôpitaux de Paris

Hacettepe University

Pitié-Salpêtrière Hospital

University of Liège

Assaf Harofeh Medical Center

Centro Cardiologico Monzino

Benha University

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Prognostic evaluation of transcatheter arterial embolization for unresectable renal cell carcinoma with distant metastasis

BJU International (2001)

T Onishi Yukihiko Oishi Yutaka Suzuki K Asano

To evaluate the efficacy of transcatheter arterial embolization (TAE) in patients with unresectable renal cell carcinoma (RCC) and distant metastasis at the time of diagnosis.The study included 54 patients with histologically defined RCC (by biopsy in 28 and autopsy in 26) who were unable to undergo nephrectomy mainly because their performance status was poor (score > or = 2). The patients were classified into two groups; 24 patients who underwent TAE with ethanol and 30 patients who did not. The two groups were compared for several clinical factors, mainly focusing on the prognosis.There were no significant differences in the clinical factors, including performance status, tumour diameter, vascular invasion, lymph node involvement, adjuvant therapy, metastatic organs or the number of metastases between the groups. However, the proportion of patients with para-neoplastic signs in those undergoing TAE was greater than that in those not, and the difference was significant (chi squared 0.35, P < 0.05). The median survival of the two groups was 229 days (TAE) and 116 days (no TAE). The 1-, 2- and 3-year survival rates in the TAE group were 29%, 15% and 10%, respectively, and in those not undergoing TAE were 13%, 7% and 3%, respectively. Those undergoing TAE had a significantly better prognosis than those who did not (P = 0.019). The adverse effects in patients undergoing TAE with ethanol included fever, back pain on the affected side, nausea and vomiting, but all the patients recovered from these adverse effects.TAE with ethanol is a safe and effective treatment for patients with unresectable disseminated RCC and a poor performance status; TAE with ethanol not only induces ablation of the primary tumour, but also prolongs survival.

Arterial Embolization

10.1046/j.1464-410x.2001.00070.x

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Citations (52)

[Diagnosis and treatment of renal angiomyolipoma].

PubMed (1985)

Norio Iizuka Fujio Masuda Makoto Miki Yukihiko Ohishi Gyojiro Nakada

We have hitherto reported 6 cases of renal angiomyolipoma. Recently, we encountered two more such cases. Case 1 is a 34-year-old woman with fever as the chief complaint. DIP revealed a tumor mass in the right upper pelvic pole. This mass showed a strong echo level on ECHO and adipose tissue of low density on CT scan. Therefore, the patient was diagnosed as having renal angiomyolipoma. Since liposarcoma was not ruled out by the examination of frozen sections during operation, nephrectomy was performed. Case 2 is a 40-year-old woman. Diagnosed as having bilateral renal angiomyolipoma, she underwent right nephrectomy 14 years ago. Two years ago, she had heavy hematuria, and had embolization of the left renal artery. She has had no bleeding since the embolization. We are of the view that ECHO and CT can are very useful for diagnosis of renal angiomyolipoma, and embolization for heavy hematuria, a complication, should be performed first of all.

Angiomyolipoma

Angiolipoma

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[Fine needle aspiration of neck tumor. Application of cytological, bacteriological and hormonal examinations].

PubMed (1983)

Akira Miyauchi Shun Takai S Morimoto T Onishi S Kawamura

Aspiration of neck tumors with a fine needle combined with cytological, bacteriological and hormonal examinations greatly improved the accuracy of the differential diagnosis of the neck tumors. Fine needle aspiration cytology in 45 patients with thyroid tumor gave only 4% (1/25) false negative diagnosis and 0% (0/20) false positive diagnosis for carcinoma, whereas false negative and false positive diagnosis by palpation were 34% and 4%, respectively and those by soft tissue roentgenogram were 55% and 0%, respectively. Differential diagnosis of histological types of thyroid carcinoma was possible by cytology. Fine needle aspiration of cervical lymph nodes gave the diagnosis of malignant lymphoma, metastatic squamous cell carcinoma, adenocarcinoma or inflammatory changes. Bacterial culture from the aspirate yielded causative microorganism in 5 patients including 4 with tuberculosis. The specimens aspirated from thyroglossal duct cysts or branchial cysts showed specific appearance and cytological feature. The aspirate from a parathyroid cyst was watery clear and contained high amount of parathyroid hormone. Dark brown serous aspirate from extrathyroidal mass suggested metastatic lesion from occult papillary carcinoma of the thyroid in 2 patients. Demonstration of very high content of thyroglobulin of the aspirate determined by radioimmunoassay supported the diagnosis, which was confirmed later at surgery. This method has become a routine work in our out-patient clinic.

Neck mass

Occult

Metastatic carcinoma

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Citations (1)

Hyperthermia with Simultaneous Administration of Interferon Using Established Human Renal Carcinoma Heterotransplanted in Nude Mice

British Journal of Urology (1989)

T Onishi T Machida Y. Mori Norio Iizuka Fujio Masuda

Using human renal carcinoma heterotransplanted in nude mice, the effects of the combined use of hyperthermia and interferon (natural human interferon-alpha; IFN-alpha, and recombinant interferon-gamma; IFN-gamma) were examined. The hyperthermic device used was the Clini-Therm, Mark VII, 915 MHz, microwave. The administration of interferon was started immediately before hyperthermia and carried out on consecutive days. The combined use of hyperthermia and IFN was compared with hyperthermia and with IFN alone. The combined use of hyperthermia and IFN-alpha was shown to have significant anti-tumour effects compared with the former or latter alone. Of 10 nude mice (10 implanted tumours) used for the experiment, 5 showed complete disappearance of the implanted tumours and the others showed prolongation of survival. Combined treatment with IFN-gamma and hyperthermia showed no significant effect when compared with other treatment groups. Combined treatment with local hyperthermia and IFN-alpha may have some application to the clinical management of renal carcinoma.

Microwave heating

10.1111/j.1464-410x.1989.tb05180.x

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[A case of arteriovenous fistulae secondary to renal cell carcinoma accompanied by congestive heart failure].

PubMed (1983)

Gyojiro Nakada T Machida Fujio Masuda T Onishi Hiro Yamazaki

The patient was a 62-year-old male who had visited a physician with the chief complaint of fever. After IVP and CT scanning, left real carcinoma was suspected and he was transferred to our hospital on March 2, 1982. The chest X-ray showed cardiac enlargement, distention of the pulmonary veins and symptoms of congestive heart, such as dyspnea. Selective renal angiography revealed marked arteriovenous fistulae present in the neovascularity, while cardiac echo and VCG did not suggest any disease of the endocardium or the valves. Thus, the case was diagnosed as cardiac insufficiency caused by renal cell carcinoma accompanied by arteriovenous fistulae. On March 31, 1982, left transabdominal nephrectomy was performed. The specimen measured 6 x 6.5 x 13.5 cm and weighed 395 g. Histological examination of the specimen showed clear cell carcinoma, and fragmentation of the lamina elastica was observed in the arteries. Improvements in the chest X-ray findings as well as the subjective symptoms were observed post-operatively, and the patient was discharged on April 21, 1982. Since cases of renal cell carcinoma accompanied by renal arteriovenous fistulae in which congestive heart failure develops are rare in Japan, we have reported this case.

Endocardium

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A CLINICAL STUDY OF DECREASED BONE DENSITY IN THE PATIENTS TREATED WITH LONG TERM LUTEINIZING HORMONE RELEASING HORMONE ANALOGUE (LHRH-a)

The Japanese Journal of Urology (1998)

Yasuyuki Suzuki Kohsuke Aikawa Yukihiko Oishi Hajime Yamazaki T Onishi

(Background) It is well known that androgens play an important role in bone metabolism and male hypogonadism induce osteoporosis. Luteinizing hormone-releasing hormone analogue (LHRH-a) which is essential for conservative therapy of prostatic carcinoma (CaP) ultimately reduces circulating testosterone to castration levels. The purpose of this study was to determine the risk of decrease of bone mineral density in men receiving LHRH-a for CaP.(Patients and Methods) Fifty-three man with CaP aged 63 to 95 years (mean 75.5 years) were included in this study. Seven patients received LHRH-a with estrogen drug, forty-six patients received LHRH-a with or without anti androgen drug. To estimate patient's bone density we use the second metacarpal bone density using a microdensitometry method.(Results) Blood level of sex hormone of the forty-six patients who were received LHRH-a without estrogen, was the same as that of castration. Patients who were treated more than twelve months had less bone density than patients who were treated less than eleven months. As the duration of medical castration period was prolonged, patients bone density were reduced. Whereas seven patients who received estrogen drug did not find a decrease of bone density regardless of duration of treatment period.(Conclusions) Hypogonadism induced LHRH-a also reduce bone density, so there is a risk of iatrogenic osteoporosis caused by therapy for CaP with LHRH-a. Patients with osteoporosis easily suffer from a much complicated and pernicious bone fracture, so we should measure bone density of male patients same as female treated with LHRH-a for a long term.

Bone remodeling

Leuprorelin

10.5980/jpnjurol1989.89.961

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Citations (7)

Clinical Study of Patients with Renal Carcinoma Surviving for more than 10 Years after Nephrectomy

British Journal of Urology (1992)

T Onishi T Machida Fujio Masuda Norio Iizuka H Shirakawa

Summary Of 207 patients with renal carcinoma we studied 50 who survived for more than 10 years after nephrectomy. These 50 patients were younger than the others at the time of operation and included more females. They had lower stage and lower grade tumours. Recurrence was detected in 18/50 patients and 6 died from cancer. Recurrence developed approximately 10 years after nephrectomy. Eleven patients with recurrences had metastases to a single organ and 9 received multidisciplinary treatment, mainly surgery and radiotherapy. The survival rate 10 years after nephrectomy was lower in patients with recurrences than in those without recurrent tumours and there was a significant decrease in the survival rate 17 years after nephrectomy. Although the patients had low grade and low stage tumours 10 years after nephrectomy, careful follow‐up is recommended in such cases as it is possible that they may have dormant tumours.

Renal carcinoma

10.1111/bju.1992.70.5.483

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Citations (7)

Histological features of hypovascular or avascular renal cell carcinoma: the experience at four university hospitals

International Journal of Clinical Oncology (2002)

T Onishi Yukihiko Oishi H Goto S. Yanada Kazuhiro Abe

Vascularity

Avascular Necrosis

Chromophobe cell

Clear cell carcinoma

10.1007/s101470200023

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Citations (26)

[Anti-tumour effect of UFT on human renal cell carcinoma heterotransplanted into nude mice].

PubMed (1988)

T Onishi T Machida Fujio Masuda Masaya Furuta Ikuko Kondo

1) Using two histologically different human renal cell carcinomas heterotransplanted into nude mice, the antitumour effect of UFT was investigated, and an attempt was made to analyze the properties of the tumour strains where a drug efficacy was noted. 2) The two strains used were the JRC 1 strain (tumour doubling time of 9.4 days, clear cell type, papillary histologic pattern, grade 3) and the JRC 11 strain (tumour doubling time of 2.72 days, granular cell type, anaplastic histologic pattern, grade 4). 3) Two dose groups were set up, one receiving 10 mg/kg of tegafur (FT) and 22.4 mg/kg of uracil and the other receiving 20 mg/kg of FT and 44.8 mg/kg of uracil. Each group was further divided into an early administration group (start of administration 3 days after the tumour transplantation) and a late administration group (start of administration at a time when the transplanted tumour proliferated to weight of 100 to 300 mg). 4) Effect as noted in the tumour proliferation inhibition rate was seen only in the group receiving 20 mg/kg of FT and 44.8 mg/kg of uracil in both early and late administration groups of the JRC 1 strain. Among these groups only the early administration groups showed a histological positive effect. 5) The fact that the measured 5-FU intra-tumour concentration in the JRC 1 strain was only 1/4 that of the JRC 11 strain demonstrates more susceptibility of JRC 1 strain to UFT. Moreover, intratumoral concentration of 5-FU differed markedly even with the same administration method and dosage level. This result indicates that intra-tumour concentration will be different if the histological pattern differs.

Uracil

Doubling time

Tegafur

Strain (injury)

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IMMUNOLOGICAL STUDY ON RENAL CELL CARCINOMA IN DIALYSIS PATIENTS WITH ACQUIRED CYSTIC DISEASE OF KIDNEYS

The Japanese Journal of Urology (1991)

T Onishi T Machida Fujio Masuda Sayuki Torii H Shirakawa

The immunological study of the major histocompatibility complex (class I, class II and DR antigens), tumour infiltrating lymphocytes (TIL), regional lymph node lymphocytes (RLNL) and peripheral blood lymphocytes (PBL) was evaluated on the basis of immunohistochemical staining using monoclonal antibodies of each subset of lymphocytes in a series of 16 patients with renal cell carcinoma. Two renal cell carcinomas in dialysis patients with acquired cystic disease of the kidneys (ACDK) were also included in this study. With regard to the immunological environment, a comparative study between renal cell carcinoma accompanied with ACDK and 14 other renal cell carcinoma was carried out. The results are described below: 1) With regard to the expression of MHC antigens in tumour cells, the degrees of expression of MHC class I, class II and DR-antigen in case 1 were higher than that of the other 14 renal cell carcinomas. On the other hand, no expression of MHC was detected in case 2. 2) As to the subsets of TIL, the CD25 (IL-2 receptor) was not expressed in all the renal cell carcinoma. As to the T cell receptor (TCR-alpha/beta chain), the degree of expression was the same in case 1 and the other 14 cases. On the other hand, no TCR was detected in the case 2. As to the other subsets of TIL (CD3, CD4, CD8, CD16 and CD20), the rates of the infiltration were the same in case 1 and the other 14 cases, but those in case 2 were lesser than in all other 14 cases.(ABSTRACT TRUNCATED AT 250 WORDS)

10.5980/jpnjurol1989.82.1800

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