I V Pandrea

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A M Székely

Maria Sultana Mihailovici

Grigore T. Popa University of Medicine and Pharmacy

Max Reynes

Menoufia University

E Carasevici

Institutul Regional de Oncologie

E Târcoveanu

Grigore T. Popa University of Medicine and Pharmacy

C Dragomir

Transylvania University of Brașov

Cooperative Institutions

Grigore T. Popa University of Medicine and Pharmacy

Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi

Romanian Society of Nephrology

Spitalul Clinic C.F. Iasi

Academy of Romanian Scientists

Spitalul Clinic de Recuperare

Menoufia University

Centre de Coopération Internationale en Recherche Agronomique pour le Développement

Agropolis International

Institut National Polytechnique de Toulouse

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An immunohistochemical study of P53 protein on colorectal carcinomas.

PubMed (1995)

I V Pandrea Maria Sultana Mihailovici E Carasevici A M Székely Max Reynes

To investigate the frequency of immunohistochemical expression of p53 protein in colorectal carcinomas; to evaluate the correlation between p53 alterations and the histopathological parameters; to determine the prognostic significance of this tumor marker. PATIENT POPULATIONS: Fourty patients with colorectal carcinomas.Paraffin embedded normal and tumoral tissues, stained, with HES, PAS, PAS-Alcian Blue stains. For detecting the p53 protein, a three step (streptavidin-biotin immunoperoxidase) immunohistochemical method was used.28 out of 40 (70%) colorectal carcinomas were positive for p53. The identification of nuclear accumulations of p53 protein in the present study was significantly correlated with the anatomic site and tumor stage.The mutational pattern observed in this study was substantially as expected. The p53 overexpression is present in advanced stage, thus demonstrating the prognostic value of this marker.

Immunoperoxidase

P53 protein

P53 expression

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