H Chelibonova-Lorer

Bulgarian Academy of Sciences

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E. Gavazova

Bulgarian Academy of Sciences

Sergey V. Ivanov

Vanderbilt University Medical Center

M. Antonova

Bulgarian Academy of Sciences

S Ivanov

Forschungszentrum Jülich

Karaivanova Vk

Bulgarian Academy of Sciences

Zhivkov

Ivanov Sx

N Tyutyulkova

Chemical Pharmaceutical Research Institute

S Tuneva

U Gorantcheva

Cooperative Institutions

Bulgarian Academy of Sciences

Sofia University "St. Kliment Ohridski"

Institute of Molecular Biology

Institute of Biophysics and Biomedical Engineering

Institute of Biophysics

Centre National de la Recherche Scientifique

Institute of Cell Biology

Charles University

Czech Academy of Sciences, Institute of Microbiology

Czech Academy of Sciences, Institute of Physiology

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Effect of silymarin (Carsil) on the microsomal glycoprotein and protein biosynthesis in liver of rats with experimental galactosamine hepatitis.

PubMed (1983)

N Tyutyulkova U Gorantcheva S Tuneva H Chelibonova-Lorer E Gavasova

The effect of the hepatoprotective drug silymarin (Carsil) on the incorporation rate of 14C-leucine into total proteins and on the biosynthesis of UDP-N-acetylhexosamine and microsomal glycoproteins using 14C-glucose of rat liver with D-galactosamine hepatitis was studied. It was found that i.p. treatment with Carsil in a dose of 140 mg/kg applied for 4 consecutive days partly abolishes the inhibitory effect of galactosamine on protein and glycoprotein biosynthesis. The specific activity of 14C-labelled UDP-N-acetylhexosamine is higher in the liver of D-galactosamine treated rats, compared with the specific activity of the nucleotide from liver pretreated with Carsil and then injected with galactosamine. This fact supports the suggestion that Carsil probably activates the metabolic conversion of UDP-hexosamine to the acetylated metabolite-UDP-N-acetylhexosamine, which is the normal liver cell metabolite, in liver cells.

Galactosamine

Liver cell

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Citations (8)

Effect of cycloheximide on the incorporation of [14C]glucosamine into UDP-N-acetylglucosamine, cell free and protein-bound N-acetylneuraminic acid, and plasma membrane glycoproteins of chicken liver

Biochemical Pharmacology (1982)

H Chelibonova-Lorer Sergey V. Ivanov E. Gavazova

N-Acetylneuraminic acid

Membrane glycoproteins

10.1016/0006-2952(82)90433-6

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Multiple forms of chicken liver and hepatoma Mc-29 microsomal and plasma-membrane sialyl and fucosyltransferases

International Journal of Biochemistry (1984)

Sergey V. Ivanov M. Antonova E. Gavazova H Chelibonova-Lorer

Sialyltransferase

Fucosyltransferase

10.1016/0020-711x(84)90233-7

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Citations (5)

Effect of fluororotic acid on the sialylation of the chicken liver, hepatoma MC-29 and serum glycoconjugates.

PubMed (1988)

Sergey V. Ivanov E. Gavazova M. Antonova H Chelibonova-Lorer

Fluororotic acid, an orotic acid analogue which interferes with the nucleotide and RNA biosynthesis, was tested to determine its effect on: a) 14C-glucosamine and 14C-N-acetylmannosamine incorporation into acid-soluble nucleotide-sugars and into b) glycoconjugates from chicken liver and hepatoma induced by the avian leukosis strain Mc-29. In vivo metabolism studies indicated that this agent alters the nucleotide biosynthesis in both tissues investigated and causes a decrease in the sialylation rate of liver, hepatoma and serum glycolipids and glycoproteins.

Glycoconjugate

Chicken Liver

Orotic acid

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Activity and characterization of sialyltransferase from serum of normal rats, of rats bearing Zajdela ascitic hepatoma, in normal host liver and in Zajdela hepatoma cells.

PubMed (1996)

Ivanov Dg Karaivanova Vk Ivanov Sx H Chelibonova-Lorer

Comparative studies on the content of sialic acid and on the sialyltransferase activity in normal serum and in serum of rats with Zajdela ascitic hepatoma in different phases of tumor development have been conducted. Unlike the serum from animals with tumors, in which the sialic acid quantity increases in dependence of the stage of tumor development, the activity of serum sialyltransferase statistically augmented only in serum of rats at the final stage of tumor progression. The sialyltransferase activity towards asialofetuin as an acceptor in normal liver and in Zajdela hepatoma cells, was measured and a decrease in this activity in tumor cells as well as in host liver was found. When lactose was used as acceptor, again lower enzyme activity in the tumor cells in comparison with that in liver was established, but in liver and in hepatoma cells the predominant 14C-labelled product of the sialyltransferase assay was alpha (2-6) sialyllactose isomer. The results contribute to the biochemical characterization of rat Zajdela hepatoma.

Sialyltransferase

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Citations (1)

[Rate of (32 P)-phosphate incorporation into acid-soluble and rRNA mononucleotides from myeloid tumour (Graffi) in mice].

PubMed (1972)

H Chelibonova-Lorer L Karamoucheva L.B. Dolapchiev Zhivkov M Jakimov

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The use of D‐galactosamine for a pulse‐chase study of ribosomal RNA maturation in rat liver

FEBS Letters (1977)