Abstract Das pharmakologisch interessante Metaraminol (I) wurde in der (‐)‐erythro‐ Form nach Acetylierung zu (II) zu der Verbindung (III) veräthert und die Acetylgruppierung wieder zu (IV) abgespalten.
INTRODUCTION DEPOSITION of amprolium1 [l-(4-amino-2-n-propyl-5-pyrirnidinylmethyl)-2-picolinium chloride · HCl] in egg yolk occurs when hens are given the coccidiostat in feed (Polin et al., 1962a). Administration of the drug in water would presumably result in a similar effect. A series of experiments was performed to determine dose-response curves relating to amprolium deposition in egg yolk from feed and water administration. The results are presented in this report. METHODS White Leghorn hens 7 to 20 months of age were housed in groups of 4 in 3-deck, wire-floored batteries within a constant temperature room of 22 ± 2°C. Medicated ration, when fed, was prepared from a commercial breeder ration to which amprolium, as pure drug, was added via a pre-mix of sifted (#40 sieve) diet. Medicated drinking water was prepared fresh each day from a stock solution of 9.6% Amprol.2 Water was supplied in stainless steel troughs which were washed daily at the . . .
Abstract α‐Brom‐acetophenone (I) und Formamid (II) geben 4(5)substituierte Pheny1= imidazole (III), aus α‐Amino‐acetophenon (IV) und Cyanamid (V) entsteht 2‐Ainino‐4(5)‐phenylimidazol (VI), Aus Benzamidinen (VII) und Aminoacetaldehyddiäthylacetal (VIII) entstehen 2‐Phenyl‐imidazole (IX); aus (I) und (VII) erhält man nach einer Zweiphasen‐Kondensation die 2,4‐Bis‐phenyl‐Derivate (X).
GLYCARBYLAMIDE (4,5-imidazoledicarboxamide, see Cuckler et al., 1958) is a medicant in use for prevention of coccidiosis in chickens. The drug is not recommended for use in adult birds, yet the possibility exists that it may inadvertently be fed to them. This raises the question of its effect on the reproductive performance of adult chickens and the possibility of its deposition in eggs. To obtain these data the following experiments were conducted. Ten White Leghorn hens and one rooster were housed in each of 15 wire-floored cages in a frame building. They were fed a commercial breeder ration for a 10-day period (Control Period), then diets containing glycarbylamide at levels ranging from 0.02 to 0.16% for 21 days (Experimental Period No. 1), and finally refed non-medicated diets for 21 days (Recovery Period). The cages were randomly reassigned to the treatments and the birds again fed the diets containing…
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInhibition of adrenal phenethanolamine-N-methyltransferase by substituted imidazolesN. P. Jensen, S. M. Schmitt, T. B. Windholz, T. Y. Shen, L. R. Mandel, B. Lopez-Ramos, and C. C. PorterCite this: J. Med. Chem. 1972, 15, 4, 341–344Publication Date (Print):April 1, 1972Publication History Published online1 May 2002Published inissue 1 April 1972https://pubs.acs.org/doi/10.1021/jm00274a001https://doi.org/10.1021/jm00274a001research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SummaryLigated intestinal sections of the digestive tract in chicks were injected in vivo with 8 mg of the coccidiostat, amprolium. Only the duodenum absorbed significant amounts of the drug (91%) in a 1-hour absorption period. A dose-absorption curve for the duodenum revealed a linear response to about 12 mg and a plateau portion associated with fluid accumulation in loops when higher doses of the drug were introduced. Thiamine introduced simultaneously with .315 mg of amprolium (an antimetabolite of thiamine) decreased amprolium absorption significantly when thiamine/amprolium ratios exceeded 4, and amprolium in excess over thiamine decreased thiamine absorption at molar ratios exceeding 7.5.
A quantitative biuret method for the determination of protein has been applied to the measurement of antibody N. The nitrogen contents of duplicate antigen-antibody precipitates from rabbit anti-bovine albumin serum and rabbit anti-egg albumin sera, plus the homologous antigens, were determined by the biuret and micro-Kjeldahl methods. The results agreed within ± 0.02 mg nitrogen with precipitates containing 0.1 to 0.5 mg antibody nitrogen.
