Jixiong Hu

Central South University

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Weidong Dai

Tea Research Institute

Xiongying Miao

Second Xiangya Hospital of Central South University

Dewu Zhong

Central South University

Shou-Zhi Xiong

Central South University

Jiangsheng Huang

Central South University

Zhongkun Zuo

Second Xiangya Hospital of Central South University

Yu Wen

Yanshan University

Wei Liu

Chinese Academy of Medical Sciences & Peking Union Medical College

Shengfu Huang

Jiangsu Cancer Hospital

Xiaohua Lei

University of South China

Cooperative Institutions

Central South University

Second Xiangya Hospital of Central South University

Xiangya Hospital Central South University

Huazhong University of Science and Technology

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Nanjing Medical University

Fudan University

Southern Medical University

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Atlas of Anatomic Hepatic Resection for Hepatocellular Carcinoma

Springer eBooks (2018)

Jiangsheng Huang Xianling Liu Jixiong Hu

Surgical resection

10.1007/978-981-13-0668-6

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Cell-free DNA methylation markers for differential diagnosis of hepatocellular carcinoma

BMC Medicine (2022)

Biyuan Luo Fang Ma Hao Liu Jixiong Hu Le Rao

Abstract Background Aberrant DNA methylation may offer opportunities in revolutionizing cancer screening and diagnosis. We sought to identify a non-invasive DNA methylation-based screening approach using cell-free DNA (cfDNA) for early detection of hepatocellular carcinoma (HCC). Methods Differentially, DNA methylation blocks were determined by comparing methylation profiles of biopsy-proven HCC, liver cirrhosis, and normal tissue samples with high throughput DNA bisulfite sequencing. A multi-layer HCC screening model was subsequently constructed based on tissue-derived differentially methylated blocks (DMBs). This model was tested in a cohort consisting of 120 HCC, 92 liver cirrhotic, and 290 healthy plasma samples including 65 hepatitis B surface antigen-seropositive (HBsAg+) samples, independently validated in a cohort consisting of 67 HCC, 111 liver cirrhotic, and 242 healthy plasma samples including 56 HBsAg+ samples. Results Based on methylation profiling of tissue samples, 2321 DMBs were identified, which were subsequently used to construct a cfDNA-based HCC screening model, achieved a sensitivity of 86% and specificity of 98% in the training cohort and a sensitivity of 84% and specificity of 96% in the independent validation cohort. This model obtained a sensitivity of 76% in 37 early-stage HCC (Barcelona clinical liver cancer [BCLC] stage 0-A) patients. The screening model can effectively discriminate HCC patients from non-HCC controls, including liver cirrhotic patients, asymptomatic HBsAg+ and healthy individuals, achieving an AUC of 0.957(95% CI 0.939–0.975), whereas serum α-fetoprotein (AFP) only achieved an AUC of 0.803 (95% CI 0.758–0.847). Besides detecting patients with early-stage HCC from non-HCC controls, this model showed high capacity for distinguishing early-stage HCC from a high risk population (AUC=0.934; 95% CI 0.905–0.963), also significantly outperforming AFP. Furthermore, our model also showed superior performance in distinguishing HCC with normal AFP (< 20ng ml −1 ) from high risk population (AUC=0.93; 95% CI 0.892–0.969). Conclusions We have developed a sensitive blood-based non-invasive HCC screening model which can effectively distinguish early-stage HCC patients from high risk population and demonstrated its performance through an independent validation cohort. Trial registration The study was approved by the ethic committee of The Second Xiangya Hospital of Central South University (KYLL2018072) and Chongqing University Cancer Hospital (2019167). The study is registered at ClinicalTrials.gov(# NCT04383353 ).

Cell-free fetal DNA

10.1186/s12916-021-02201-3

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Newly found variations of the right posterior portal vein identified radiologically in 1,003 Chinese patients: a cross-sectional study

Annals of Translational Medicine (2022)

Jinyu Li Weidong Dai Jixiong Hu Jiangsheng Huang Xianling Liu

The anatomy of the right posterior portal vein (RPPV) plays an important role in planning hepatic resection, living transplantation and interventional radiological procedures, yet the incidence of variations of RPPV without a common trunk in Chinese persons is still unclear. Therefore, we conducted this study and discussed its clinical implications.A retrospective analysis of multidetector computed tomography (MDCT) scans was performed in 1,933 patients with various abdominal pathologies between September 28, 2018 through May 23, 2019. After excluding 930 patients, a total of 1,003 patients were included in this study. Variations of the RPPV without a common trunk were classified according to classification standards.A total of 1,003 patients were included. RPPV without a common trunk was found in 216 (21.54%, 216/1,003) patients. Among them, we identified three variations of the origin from the right portal vein (RPV): first separate origin of P6, P7, or simultaneous separate origin of P6 and P7, and the incidences of these three variations were 1.50% (15/1,003), 6.58% (66/1,003) and 13.46% (135/1,003), respectively. Among 1,003 patients included in this study, 787 patients (78.46%, 787/1,003) showed that RPPV normally divided into P6 and P7 branches.Variations of the RPPV without a common trunk were not rare in Chinese population. Knowledge of this anatomic variation of the RPPV is extremely important for hepatic and transplant surgeons and interventional radiologists.

Clinical Significance

10.21037/atm-22-4837

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Obstructive Jaundice Caused by Tumor Emboli from Hepatocellular Carcinoma

The American Surgeon (1999)

Jixiong Hu Zhiming Pi May Ying Yu Yongguo Li Shou-Zhi Xiong

Hepatocellular carcinoma (HCC) presenting as obstructive jaundice due to intrabile duct tumor growth is being reported with increasing frequency. We describe our clinical experiences and evaluate the results of different operative procedures for this disease. A retrospective study was undertaken to review 18 patients with obstructive jaundice by tumor emboli from HCC during a 15-year period of time. We reviewed clinical features, types of operative procedures, operative findings, and survival in the patients. All patients on initial examination had recurrent episodic jaundice or cholangitis. Types of surgical procedures were choledochotomy with T-tube drainage alone in nine patients, choledochotomy with T-tube drainage followed by hepatectomy in six, and T-tube drainage followed by transcatheter hepatic arterial chemoembolization in the remaining three patients. Liver cirrhosis was the associated disease in 15 (83.3%). There were three postoperative deaths (16.7%). The mean survival time for nine patients with external drainage alone was 4.5 months. For the three patients with T-tube drainage and transcatheter hepatic arterial chemoembolization, mean survival time was 11 months. Six patients who had undergone hepatectomy had a better postoperative survival time, with 1 surviving for more than 3 years and another alive for 70 months, without evidence of recurrence at the moment. Jaundice is not necessarily a harbinger of advanced disease and a contraindication for surgery. Managed properly, these patients will have satisfactory palliation and occasional cure.

Contraindication

10.1177/000313489906500504

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Intrahepatic Glissonian approach for mesohepatectomy in the management of primary hepatic tumors

Chinese Journal of Practical Surgery (2009)

Jixiong Hu Dai Wei-dong Xiongying Miao

Objective To evalualte intrahepatic Glissonian approach for mesohepatectomy in the management of primary hepatic tumors. Methods The clinical data of 24 cirrhotic patients with primary liver tumor admitted from May 2005 to December 2007 at the Second Xiangya Hospital of Central South University were analyzed retrospectively. Results Mesohepatectomy was feasible with the proposed technique in all patients. No patients experienced massive bleeding during the operation. The estimated intraoperative mean amount of blood loss was 300mL (range 200 to 1200mL). The mean operating time was (258±60) minutes and only 2 patients required blood transfusion for 2U. Minor postoperative complications included bile leakage in 3 cases, subphrenic infection in 2 cases and resolved with conservative management. No hospital mortality occurred. Conclusion Intrahepatic Glissonian access for mesohepatectomy in cirrhotic patients is safe and effective. It may reduce intraoperative blood loss and the need for the pringle maneuver.

Conservative Management

Intrahepatic Cholangiocarcinoma

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[Efficiency of isolated caudate lobe resection for huge hepatocellular carcinoma (10 cm or larger in diameter)].

PubMed (2018)

Bo Kyu Yang Chun Liu Jixiong Hu Weidong Dai Zebing Song

To explore the feasibility and efficacy of isolated caudate lobe resection for caudate lobe in huge hepatocellular carcinoma(10 cm or larger in diameter). Methods: Clinical data of 27 patients with hepatocellular carcinoma larger than 10 cm who underwent isolated caudate lobe resection from January 2001 to December 2011 were retrospectively analyzed. Results: All the patients successfully completed the operation. There was no postoperative death. Median operative time was 288 min, and the estimated intraoperative blood loss was 2 260 mL. Postoperative morbidity rate was 44.4%. The patients were discharged successfully after active treatment. Overall survival rates at 1, 3, and 5 years were 80.2%, 52.1%, and 27.1%, respectively. Conclusion: Isolated caudate lobe resection is safe and effective for caudate lobe huge hepatocellular carcinoma.目的：探讨尾状叶巨块型肝癌(直径≥10 cm)行单纯全尾状叶切除手术的可行性及疗效。方法：回顾性分析2001年1月至2011年12月27例单纯全尾状叶切除的巨块型肝癌患者的临床资料。结果：27例患者均顺利手术，无死亡病例，平均手术时间288 min，平均出血量2 260 mL，44%的患者出现了术后并发症，经积极处理均顺利出院。术后1，3，5年的总生存率分别是80.2%，52.1%，27.1%。结论：尾状叶巨块型肝癌行单纯全尾状叶切除安全有效。.

Caudate lobe

Lobe

10.11817/j.issn.1672-7347.2018.09.014

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Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway

Biomedicine & Pharmacotherapy (2018)

Yu Fang Guoxing Liu Chengzhi Xie Ke Qian Xiaohua Lei

TRPV4

10.1016/j.biopha.2018.03.014

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A study on expression of enzymatic activity of GST_(pi ) , HO_1 and TPII in primary hepatocellular carcinoma

Zhonghua gan-dan waike zazhi (2004)

Jixiong Hu

Objective To study the expressive features of GST pi , HO 1 and TPⅡ and their clinicopathological significance in the central cancer tissue, edge cancer tissue, pericancerous liver tissue and non cancer liver tissue. Methods The expression of GST pi , HO 1 and TPⅡ was detected by immunohistochemical method of avidin biotin complex in the 10% neutral formalin fixed and routinely paraffin-embedded sections of 37 specimens. Results Clinical assay showed significantly lower values of AFP, AFU and PAB and the positive rate of SHCSP in postoperative patients, but the values of ALB was significantly higher. The positive rate and the score of GST pi , HO 1 and TPⅡ were markedly higher in the central cancer tissue or edge cancer tissue than in the pericancerous liver tissue or non-cancer liver tissue. Meanwhile, the positive rate and the score of GST pi and HO 1 were remarkably higher in the central cancer tissue than in the edge cancer tissue. The score of GST pi and HO 1 was correlated to preoperative AFP value. No correlation was found among the scores of enzymatic expression and other clinicopathological features of the tumor. Conclusions The expression of GST pi , HO 1 and TPⅡ might be closely related to the carcinogenesis of the liver tissue. The assay of GST pi and TPⅡ might be of important clinical values for guiding postoperative chemotherapy and raising the effect of chemotherapy for the primary hepatocellular carcinoma.

Liver Cancer

Liver tissue

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Expression of gene Plk1 and its relationship with prognosis of hepatocellular carcinoma: an analysis of 213 cases

Shijie huaren xiaohua zazhi (2009)

Zili He Dewu Zhong Zheng He Xiongying Miao Jixiong Hu

PLK1

10.11569/wcjd.v17.i2.146

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