Yi-Yong Cheng

Academy of Military Medical Sciences

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Shutian Li

Xi'an University of Architecture and Technology

Donglan Wang

University of South China

Hong Yan

City University of Hong Kong

Wei‐Qiang Chen

First Affiliated Hospital of Jiangxi Medical College

Zhixian Gao

Academy of Military Medical Sciences

Yue Hou

Capital Medical University

Weiqiang Chen

Shantou Central Hospital

Chao Niu

Third Affiliated Hospital of Zhengzhou University

Xiaoling Zhao

Hebei University of Technology

Yue Hou

University of Science and Technology Beijing

Cooperative Institutions

Academy of Military Medical Sciences

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Capital Medical University

Shandong University

Southern Medical University

University of Chinese Academy of Sciences

Soochow University

Shandong First Medical University

Central South University

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EFFECTS OF INTRAPERITONEAL INJECTION OF HOMOCYSTEINE ON THE ABILITY OF LEARNING AND MEMORY IN RATS AND THE RELATED MECHANISMS

Yingyang Xuebao (2012)

Yue Hou Yan Hong Chao Niu YU Li-xia Weiqiang Chen

Intraperitoneal injection

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Protective effects of green tea polyphenols on cognitive impairments induced by psychological stress in rats

Behavioural Brain Research (2009)

Weiqiang Chen Xiaoling Zhao Yue Hou Shutian Li Hong Yan

Malondialdehyde

Chronic Stress

10.1016/j.bbr.2009.03.017

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Citations (53)

[Effects of stress on hippocampal Glu-NMDAR pathway in rats and mechanism of zinc protection].

Zhanhui Geng Yi-Yong Cheng Xiuling Ma Shutian Li Yonghui Wang

Aim: To observe the effects of stress on Glu uptake and NMDAR of hippocampus synaptosome in rats with different zinc status. Methods: Stress model was established by photoelectric stimulus. The behaviors of rats were tested in open-field case. 3 H -L-Glu was taken as radioligand to detect the NMDAR binding.Glu uptake was determined with radioimmunoassay. Results: Compared with CT rats, ZD rats performed less movement in open-field test, both Bmax of NMDAR and 3 H -L-Glu uptake of hippocampus in these rats were significantly decreased.Compared with corresponding non-stressed groups, the stressed groups appeared longer latency and less movement in open-field test.Increased Bmax of NMDAR and decreased 3 H -L-Glu uptake were observed in all stressed rats,but only in SZD rats these indices showed statistical difference. Conclusion: Abnormal behaviors of rats induced by photoelectric stress were observed in open-field test, which was more serious in zinc deficiency rats.It is supposed that the Glu-NMDAR pathway is involved in the process of stress reaction.As it shows in our experiment,the changes of Bmax of NMDAR and 3 H -L-Glu uptake of hippocampus synaptosome seems to be a part of the mechanisms of stress action.

Synaptosome

Radioligand

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Serum homocysteine concentrations of Chinese intellectuals and the influential factors concerned

Health (2009)

Yue Hou Hong Yan Weiqiang Chen Donglan Wang Yi-Yong Cheng

Objective: To observe the concentration of se-rum homocysteine in intellectuals and the re-lated influential factors. Methods: The concen-trations serum homocysteine and saliva cortisol were measured in 138 intellectuals from three cities, Tianjin, Guangzhou and Chengdu in China. All the subjects had senior titles of tech-nical post, aged 40-69 years. Results: The mean value of serum homocysteine concentration in intellectuals was 20.6±0.8μmol/L, higher than the reference value. With the increase of cortisol levels the homocysteine concentrations rise (P <0.05). The mean value of homocysteine con-centration was highest in 40-49 years old group. Men had higher homocysteine level than women in this investigation. According to the mean value of homocysteine concentration among different cities, Tianjin was highest, Chengdu medium, Guangzhou lowest. Conclusion: The serum homocysteine concentration of intellec-tuals is higher than the reference value. The stress level, gender and resident cities might contribute to the differences in serum homo-cysteine concentration in Chinese intellectuals.

Value (mathematics)

Plasma homocysteine

Serum concentration

Mean value

10.4236/health.2009.12014

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[Zinc deficiency on pathological changes of femur epiphyseal growth plate in rats].

PubMed (2003)

Yuehong Zhang Yi-Yong Cheng Hong Yan Shutian Li

To study zinc deficiency on pathological changes of femur epiphyseal growth plate in rats thirty Wistar rats were randomly divided into three groups: zinc-deficient group (Zd), control group (Ctr), and pair-fed group (Zp) to study the effects of zinc deficiency on femur epiphyseal growth plate of rats and the mechanism involved. After 8 weeks feeding, the histomorphology of right femur indicated that chondrocytes in the epiphyseal growth plate of Zd group were generally ill-organized and mis-shaped. The number of chondrocytes decreased. Trabecular bone in the epiphyseal of Zd group were also ill-organized, scarce and slim. The cavities of marrow in Zd animals were significantly larger than those of Ctr and Zp. The volume of trabecular bone, the mean trabecular plate density of Zd rats were significantly decreased, but their mean trabecular plate space was significantly increased. In addition, the Zd animals had significantly lower concentration of osteocalcin and growth hormone in sera. The above results suggested that zinc deficiency impaired proliferation and differentiation of chondrocytes and balance between osteoblast and osteoclast function by reduce growth hormone levels in sera. The lack of zinc in diet resulted in disorder of bone molding and ultrastructure.

Epiphyseal plate

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Effects of dietary vitamin B_(6) on spatial memory and hippocampal long-term potentiation in growing rats

Yingyang xuebao (1999)

Hong Yan Yi-Yong Cheng Donglan Wang Shutian Li

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[Recognition of neural glial cells].

PubMed (2003)

Zhanhui Geng Yi-Yong Cheng

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Antioxidant Activity of Ten Kinds of Fruits and Vegetables Extracts Including Blueberry in Vitro

Shipin yanjiu yu kaifa (2010)

Yi-Yong Cheng

FRAP method,pyrogallol autoxidation method and salicylic acid method were used to determine the antioxidant activities of ten kinds of fruits and vegetables extracts including kiwifruit,longan,blueberry,jujube,pumpkin,wax gourd,spinach,celery,balsam pear and auricularia auricula.The results suggested that the total antioxidant capacity order from strong to weak was as followes: blueberry jujube longan pumpkin balsam pearauricularia auriculakiwifruitceleryspinachwax gourd.The scavenging activities on superoxide anion free radical were as followes: longan pumpkinspinachblueberryjujubecelerywax gourdbalsam pear auricularia auricula kiwifruit.The scavenging activities on hydroxyl radical were as followes: kiwifruit blueberryceleryspinachauricularia auriculajujubelonganwax gourdbalsam pearpumpkin.

Gourd

Bitter gourd

Pyrogallol

Lagenaria

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[Effects of zinc on the expression of metallothionein isoforms in hippocampus of stressed rats].

PubMed (2005)

Wei‐Qiang Chen Yi-Yong Cheng Shutian Li Donglan Wang Zhijie Yu

This study was conducted to evaluate the effects of different doses of zinc on the expression of metallothionein isoforms in hippocampus of stressed rats.The animal model of psychological stress was developed by restraint stress for four weeks. Wistar rats were randomly assigned to eight groups as follows: control group, zinc deficiency group, pair-feed group, zinc complementarity group and their corresponding stressed groups.In zinc deficiency group, plasm zinc content was decreased, while in zinc complementarity group it's slightly increased. On the one hand, the expressions of metallothionein in brain and MT-1 mRNA, MT-3 mRNA in hippocampus were downregulated in zinc deficiency group, however, their expressions were evidently enhanced in stressed zinc deficiency group. On the other hand, inductions of metallothionein and it' s mRNAs in zinc complementarity group were increased, furthermore, stressed zinc complementarity group has more significantly yield of metallothionein and it' s mRNAs. In addition, the levels of plasma cortisol, IL-6, IL-1 and NO were increased clearly in zinc deficiency group and stressed zinc deficiency group.Our results suggested that zinc deficiency may decrease while zinc complementarity increase the expressions of metallothionein in brain and MT-1 mRNA, MT-3 mRNA in hippocampus, moreover, stress can increased their expressions dramatically. The impairment of stress on body may be involved with the nutrition status of zinc, and zinc deficiency can lower the body's resistibility to stress.

Metallothionein

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Citations (2)

qian xi xiang tu zhong guo ji qi xian shi yi yi

Tokyo Literature (2011)

Yi-Yong Cheng

中国目前正处于历史转型的关键时刻，市场经济的不断完善和对外开放水平的不断提高使得中国社会尤其是城市社会发生了翻天覆地的变化。然而，中国又有着约6亿农业人口，从社会学的角度讲，农村社会相较于城市，承载的更多的是传统社会人文历史的传承，彰显着中国作为农业大国的秩序和力量。费孝通先生的《乡土中国》成书于20世纪40年代，但却具有许多对于当代社会的现实意义。

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