Objective: To evaluate the efficacy and taxicity of thermal therapy in combination with FOLFOX4 regimen in primary hepatocarcinoma. Methods: A total of 126 patients with advanced primary hepatocarcinoma were treated with L-OHP 100 mg/m, ivgtt (day 1); CF 200 mg/m, ivgtt (day 1~5); 5-Fu 400 mg/m, ivgtt (day 1~5). The patients in treatment group received additional thermal therapy, but control group not. The efficacy and toxicitis were respectively evaluated according to RECIST criteria and NCL CTC. Results: A total of 66 patients were available for the objective efficiency and toxicity, including 7 with complete response (CR), 13 with partial response (PR), 18 with stable disease (SD). The 60 patients were involved in the control group, including 2 with CR, 6 with PR, 14 with SD. The median overall survive was 7.2 months in the treatment group and 6.5 months in control group. The main toxicities were granulocytopenia, nausea, vomiting, and mmild neurotoxicity. Conclusion: The thermal 收稿日期 (Date of reception):2015–12–07 通信作者 (Corresponding author):刘海波,Email: lhb0916@sina.com doi: 10.3978/j.issn.2095-6959.2016.03.007 View this article at: http://dx.doi.org/10.3978/j.issn.2095-6959.2016.03.007 临床与病理杂志, 2016, 36(3) http://lcbl.amegroups.com 248 原发性肝癌(primary liver cancer,PLC)是世界 第5大常见恶性肿瘤,其5年生存率仅5%~7%,每 年约导致60万患者的死亡,其中超过50%的患者来 自中国。晚期肝癌的自然生存时间约为2~6个月。 肝癌的治疗方法中手术切除仍为首选,但仅占肝 癌患者的10%,诊断时不能切除的占80%以上。 对于不适合手术切除的晚期肝癌,有效的治疗措 施包括:经导管动脉内化疗栓塞治疗(transhepatic arterial chem otherapy and embolization,TACE)、 射频消融、无水酒精注射、靶向药物等。目前肝 癌全身化疗的常用药物和方案的疗效较差,尚无 标准方案,因此迫切需要积极探讨针对晚期原发 性肝癌的有效的治疗方案。我科室近年来使用热 疗联合FOLFOX4方案治疗晚期原发性肝癌患者, 取得了较好效果,现报道如下。
Objective:To study the clinical efficacy and toxicity of BAM in interventional treatment of liver cancer.Methods:103 patients were enrolled in the study.38 of them were allocated to receive 50 mg BAM for 2～3 times,and the balance were treated with combined therapy of BAM,5 fluorouacil (1 000 mg) and mitomycin (10～20 mg) for 2～3 times.Results:The total response rate was 30.8% for BAM arm and 42.1% for the combined therapeutic arm.Fever,chill,and GI reactions are the main side effects.Conclusion:BAM is an effective agent in interventional treatment of liver cancer.
Degenerated PCR primers derived from the conservative nucleotide sequences of oleate desaturase(FAD2)of Arabidopsis thaliana were used to analyze the copy number variation of FAD2 gene among six Brassica species,and the amplified FAD2 gene fragments were further sequenced and analyzed.The cloned DNA fragments encod～212 amino acid residues at the C-terminus of FAD2.The results indicated that A.thaliana and Brassica sp.genomes had different copy numbers(1～2) of FAD2 genes and their sequences were highly homologous.In A.thaliana and Brescia sp.the amino acid sequence identity was between 88.7%～98. 8%.And the Brassica FAD2 amino acid sequences displayed lower identity from 50.0% to 86.0%with those of other plants.
Objective To explore a new method for partial mastectomy so as to avoid breast deformity due to large amount of tissue removed. Methods A partial mastectomy was performed on 40 patients for breast diseases from January,1995 to June,1998. The dead space was not sutured after removal of breast tissue. The wound surface was carbonized and bleeding points coagulated thoroughly. Needed no drainage and pressure dressing. Results All but two of those healed excellently. No obvious changes of breast appearance were found during follow up of 6-12 months after operation. An ultrasonography done for six of them showed that the dead space had disappeared. Conclusion Without closing the dead space after partial mastectomy is a safe method for preserving the breast in normal appearance.
AIM: To explore the expression of cyclooxygenase2(COX-2) in nonalcoholic fatty liver disease(NAFLD) and its significance.METHODS: The rat NAFLD model was established by giving a fat-riched diet.The expression level of COX-2 in rat livers was assayed by immunohistochemistry,RT-PCR and Western-blot.RESULTS: Light microscopy indicated that the liver injury was more obvious in the model group than in the treatment group.The levels of serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),thromboxane B2(TXB2) and interleukin-1(IL-1) in the fatty liver rats were increased as compared with those in the normal controls(P0.05).Compared to model group,levels of IL-1 and TXB2 decreased significantly in treatment group(P0.05).The 6-Keto-prostagland(6-k-PGF1α)in hepatic tissue was lower in model group than in control group,while higher in treatment group than in model group(P0.05).COX-2 mRNA was positive in model group and higher than in control group(P0.05).The level of COX-2 protein was obviously higher in model group than in control group(P0.05),but decreased significantly after Celecoxib treatment(P0.05).CONCLUSION: COX-2 promotes the development of fatty liver by mediating lipid peroxidation and lipopolysaccharide.Cyclooxygenase-2 inhibitor alleviates the liver injury in NAFLD by downregulating the expression of COX-2 and depressing the oxidative stress.
The effect of green tea polyphenols (GTPP) on lipid peroxidation was observed.The results showed that GTPP could inhibit the production of lipid peroxides (LPO) in the liver, brain and heart of the rat. After administering GTPP at the doses of 40, 80 and 100 mg/(kg·d) -1 for 15 days, the LPO and lipofucin levels were greatly reduced compared with the levels of the control group, which suggested that green tea polyphenols could inhibit LPO and maintain the bacance of the free radicals in vivo.
Objective To observe therapeutic effect of cefetamet pivoxil hydrochloride in children with acute bacterial diarrhea.Method 102 children with acute bacterial diarrhea were divided into 2 groups: cefetamet pivoxil hydrochloride group and amoxicillin/clavulanate potassium group(the control group).Results The total effective rate of treatment group was 96.30% and that of control group was 73.37%,there was significant difference in therapeutic effect between the two groups(P0.01) and the therapeutic effect in the treatment group was superior to that in the control group.Conclusion celetament pivoxil hydrochloride is an ideal drug for the treatment of childhood acute bacterial diarrhea.
Present paper described the effect of human tumor necrosis factor α (hTNFα)and β (hTNFβ) on apoptosis induced by ionizing radiation in human embryonic lung cell line 2BS diploid cells and human lung cancer cell line A549 and SPC cells. The results showed that both hTNFα and hTNFβ significantly inhibited 7Gy γ-ray-induced apoptosis in 2BS cells. In contrast, hTNFα or hTNFβ can increase the sensitivity of tumor cell lines (A549 and SPC cells) to radiation. Therefore, the results suggested that TNFα and TNFβ had potential as a therapeutic agent to protect normal cell from the radiation-induced apoptosis and to sensitize the tumour cells for the damage effect of ionizing radiation.
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