Zhu Hu

Fudan University

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空間適応高次全変動モデルに基づく画像雑音除去【Powered by NICT】

IEEE Conference Proceedings (2016)

Deng Lizhen Fang Qi Zhu Hu Gang Zhou

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[Tyrosyl-DNA phosphodiesterases: potential targets for cancer treatment].

PubMed (2016)

Zhu Hu Haowen Wang Lin‐Kun An

DNA topoisomerases-mediated DNA damages are generated from exogenous and endogenous effects, which need to be metabolized or repaired to maintain genome stability involving in many of repair enzymes. Tyrosyl-DNA phosphodiesterase 1(TDP1) and tyrosyl-DNA phosphodiesterase 2(TDP2) are two DNA repair enzymes discovered recently. TDP1 and TDP2 have the ability to hydrolyze the tyrosyl-phosphodiester bond of the phenol of tyrosine with 3’- and 5’-DNA end, respectively, which are contained in the metabolites of the damaged DNA mediated by topoisomerase 1 and topoisomerase 2, respectively. The abnormal activation and expression of TDP1 or TDP2 is the important reason for cancer development. Therefore, TDP1 and TDP2 have been regarded as potential targets in cancer therapy. In this review, we discuss the rationales of their potential as targets and development of their inhibitors together with topoisomerase poisons or DNA damaging agents.

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Isosteroidal alkaloids from the bulbs of Fritillaria tortifolia

Fitoterapia (2018)

Zhu Hu Jian-Fa Zong Abulimiti Yili Meihua Yu Haji Akber Aisa

Liliaceae

Aminophylline

10.1016/j.fitote.2018.10.019

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Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense

Journal of Natural Products (2018)

Guanghui Huang Zhu Hu Chun Lei Peipei Wang Jing Yang

Eight enantiomeric pairs of new meromonoterpenoids (1a/1b–8a/8b) and four known compounds (9–12) were isolated from Rhododendron nyingchiense. Their structures were established by spectroscopic methods, quantum chemical calculations, and X-ray crystallography. The enantiomeric pairs were acquired from scalemic mixtures by chiral-phase HPLC and showed diverse heterocyclic frameworks. Compounds 1a/1b possess a rare 6/7/5/5 heterocyclic system, and 2a/2b incorporate a new 6/6/3/5 heterocyclic system featuring a quinone motif. Compounds 3a/3b represent the first meroterpenoids with a 6/6/5 ring system from the Rhododendron genus. Putative biosynthetic pathways of these compounds are proposed. Compounds 1b, 2a–4a, 8a, 8b, and 11 exhibited weak inhibitory effects on PTP1B, with IC50 values ranging from 5.7 ± 0.5 to 61.0 ± 4.8 μM.

Quantum chemical

Stereoisomerism

10.1021/acs.jnatprod.8b00273

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Technique of mini-T sternotomy for the congenital heart diseases surgery

Harbin Yike Daxue xuebao (2002)

Zhu Hu

Objective To report the results of mini T sternotomy for the open heart surgery of congenital heart diseases.Methods To use the technique of mini T sternotomy (lower half) for the cardiac surgery of the patients with congenital heart diseases.In this group,there were 82 patients,38 men and 44 women,with ages ranging from 3～46 years.Results There were 82 patients to be successfully treated with this technique,without postoperative complications and death.CPB and aorta clamp time were (62.9±14.3)min,(42.4±8.6)min,respectively.Conclusion The advantages of this lower half mini T sternotomy approach are safe,less injury,pleasing to the eye and so on.

Median sternotomy

Clamp

Cardiothoracic surgery

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Journal of Practical Gynecologic Endocrinology (2015)

Zhu Hu

Objective To master the factors of hand hygiene of maternity nursing personnel and related effects Methods According to and health institutions medical personnel handhygiene and other relevant requirements, a survey of hand hygiene situation of 46 nursing staff in 2 Department of Obstetrics of our hospital in 2014 July Results Before and afterobstetric nursing staff hand hygiene compliance is obviously better than the operation operationConclusion Strengthening obstetric care personnel hand hygiene knowledge training, improve thecompliance of its rival health norms is a pressing matter of the moment

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Determination of sarsasapogenin in crude Anemarrhena asphodeloides and its preparation by RP-HPLC-ELSD

Zhongcaoyao (2001)

Zhu Hu

Object To show that ELSD is an excellent detector for the detection of chemical compounds devoid of chromophore, such as sarsasapogenin Methods Sarsasapogenin in crude Anemar rhena asphodeloides Bunge and its preparation was determinated by RP HPLC ELSD Results The well separated chromatographic peaks show linearity with recovery of the added sample of 100 5% in crude medicinal material and 91 38% in its preparation, r= 0 999 0 Conclusion The method was advanced, reliable, simple and can be used for quality control of crude A asphodeloides and its preparations

Chromatography detector

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Correlation Analysis on Soil Factor and Active Components of Flos sophorae

Northern Horticulture (2013)

Zhu Hu

In order to analyze the correlation between soil factor and active components of Flos sophorae,the active components of Flos sophorae were measureted and the contents of nutrition in soil were determined,then analyzed by correlation analysis.The results showed that soil total kalium was the most important factor that effected the content of rutin in Flos sophorae,significant positive correlation,coefficient of determination R2 was 0.609,followed by soil hydrolysable nitrogen,negative hydrolysis of nitrogen in soil and soil potassium;effects of content of total flavone in Flos sophorae were the dominant factor of soil available phosphorus and organic matter in soil,coefficient of determination R2 was 0.650,total flavonoids content was significantly negatively correlated with soil available phosphorus,organic matter and soil were positively correlated.

Flos

Negative correlation

Soil test

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The study on the treatment of α-cyanoacrylate alkyl combined with aethoxysklerol for type 1 tumorous isolated gastric varices

Chinese Hepatology (2008)

Zhu Hu

Objective To evaluate the clinical effect of the tissue adhesive α-cyanoacrylate alkyl combined with sclerosant 1% aethoxysklerol on the treatment of type 1 tumorous isolated gastric varices(IGV1).Methods 16 patients with IGV1 underwent endoscopic sclerotherapy with combined 1% aethoxysklerol and α-cyanoacrylate alkyl.Then the hemostatic effects,eradication of gastric varices and the clinical adverse reactions were observed colsely.Results The average time of injection was 1.56±0.51.The average total volume of α-cyanoacrylate alkyl was(1.36±0.20)ml.The average total volume of aethoxysklerol was(7.13±2.96)ml.Initial hemostasis was achieved in all patients(100%).During the follow-up period of(244.44±90.51)days,rebleeding rate was 18.75% and no mortality was observed.The varices were disappeared in 6 patients(42.86%),flattened in 6 patients(42.86%)and reduced insignificantly in 2 patients(14.28%).The total effective rate was 85.72%.Conclusion This method carried out using the tissue adhesive α-cyanoacrylate alkyl combined with the injection of 1% aethoxysklerol might be an alternative and feasible method for hemostasis and eradication of tumorous IGV1.

Gastric varices

Clinical efficacy

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Research on Adolescent Color Aesthetic and Synesthesia

Packaging Engineering (2013)

Zhu Hu

Based on theoretical knowledge of color science,youth development,aesthetics,etc,it analyzed adolescent physical characteristics,and put forward the concept of color aesthetic synesthesia.It focused on the process and characteristics of color aesthetic synesthesia driven by adolescent physical.At last it has been drawn that the energy accumulation of adolescence can be released by the color aesthetic synesthesia behavior,and they can learn from the positive,healthy,aesthetic,and passion spiritual nourishment.

Synesthesia

Passion

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