Suna Schmitz

Ludwig-Maximilians-Universität München

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Alexander Berghaus

Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde

Michaela Andratschke

Helios Amper-Klinikum Dachau

Pamela Zengel

Ludwig-Maximilians-Universität München

Ilija Alvir

University Hospital Centre Zagreb

Stefan Zahler

Ludwig-Maximilians-Universität München

P. Klemt

Bernd Muehlenweg

Wilex (Germany)

W Fassnacht

Olivier Gires

Helmholtz Zentrum München

Brigitte Mack

Ludwig-Maximilians-Universität München

Cooperative Institutions

Ludwig-Maximilians-Universität München

LMU Klinikum

München Klinik

Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde

Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde

Universitäts-HNO-Klinik Heidelberg

UCLouvain

Cliniques Universitaires Saint-Luc

KU Leuven

University Medical Center Hamburg-Eppendorf

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Multimodal therapy for synergic inhibition of tumour cell invasion and tumour-induced angiogenesis

BMC Cancer (2010)

Pamela Zengel Diana Ramp Brigitte Mack Stefan Zahler Alexander Berghaus

Squamous cell carcinoma of the head and neck (SCCHN) are highly invasive tumours with frequent local and distant recurrence. Metastasis formation requires degradation of the extracellular matrix, which is fulfilled by membrane-associated proteases such as the urokinase plasminogen activator (uPA). WX-UK1 is a competitive active site inhibitor of the protease function of uPA that impairs on the capacity of tumour cells to invade in vitro. In the present study, effects of combinations of WX-UK1 with matrix metalloprotease inhibitors (MMP, galardin®) and cyclooxygenase-2 (COX-2, celecoxib®) inhibitors on tumour cell proliferation, invasion, and angiogenesis induction were evaluated. Matrigel invasion chambers and a spheroid co-cultivation model with human fibroblast served to determine the invasive potential of both FaDu (SCCHN) and HeLa (cervical carcinoma) cells, each treated with combinations of Celecoxib®, Galardin®, and WX-UK1. Blocking of single protease systems resulted in a significant 50% reduction of tumour cell invasion using WX-UK1, while the triple combination was even more effective with 80% reduction of invasion. Additionally, a sprouting assay with HUVEC was used to test the anti-angiogenetic potential of the triple combination, resulting in a 40% decrease in the sprouting rate. A combined approach targeting different families of proteases and cyclooxygenases represents a promising adjuvant therapy.

Matrigel

Matrix metalloproteinase inhibitor

10.1186/1471-2407-10-92

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Citations (13)

Cytological and Immunocytological Monitoring of Oropharyngeal Dysplasia and Squamous Cell Carcinomas.

PubMed (2015)

Michaela Andratschke Suna Schmitz Hjalmar Hagedorn Michael Nerlich

Due to the high recurrence rates of squamous cell carcinoma of the head and neck (SCCHN) and de-novo local secondary carcinomas, a close monitoring of patients is mandatory. In doubtful cases, a clearance by histological biopsy is necessary. This, however, bears potential complications. We analyzed the application of combined cytology and immunocytology in cytological brush smears for diagnosing pre-malignant and malignant lesions of the oral/oropharyngeal cavity.Brush biopsies of 30 subsequently histologically-confirmed oral/oropharyngo-/laryngeal cavity cancer cases (all then in a recurrence status) and normal mucosa were obtained for routine cytology and immunocytology for cytokeratin-8 (CK-8). Additionally 20 samples with inflammatory lesions were investigated.Our results showed a high rate for positive prediction of oral/oropharyngo-/laryngeal dysplasia/cancer cases. Accordingly, 82% of all subsequently confirmed cases were detected by cytology alone (sensitivity). The specificity, however, of cytology was distinctly lower since several doubtful cases contained only inflammatory lesions (specificity 85%). The addition of CK-8-immunocytology did not increase the sensitivity, since the rate of detected cases by immunocytology was comparable to routine cytology (79%); however, the addition of immunocytology significantly increased the specificity (up to 90%).Routine cytology is a simple, non-invasive and cost-effective method for routine control and screening of dysplastic oral/oropharyngo-/laryngeal lesions. In doubtful cases, the addition of CK-8-immunocytology is very helpful for the distinction of reactive from neoplastic cases.

Carcinoma in situ

Epidermoid carcinoma

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Primary undifferentiated carcinoma of the trachea.

PubMed (2014)

W Fassnacht Suna Schmitz Étienne Marbaix Thierry Duprez Marc Hamoir

Primary undifferentiated or lymphoepithelial carcinoma mainly occurs in the nasopharynx. Tracheal localization is exceedingly rare. To the best of our knowledge, only four cases have been reported previously, all in Asian patients.A 61-year-old male European patient presented with hemoptysis and cough for several months. The workup revealed a primary tracheal tumor without regional or distant metastasis. The patient was treated with tracheal resection followed by end-to-end reconstruction. Pathologic analysis of the tumor, including immunohistochemistry, confirmed the diagnosis of lymphoepithelioma-like carcinoma. Testing for Epstein-Barr virus by hybridization in situ was massively positive. With a follow-up at 15 months, the patient is alive and free of disease.We report the first case of lymphoepithelioma-like carcinoma in the trachea in the European population. Treatment possibilities are discussed. They should be based on each patient's clinical presentation and the results of their preoperative workup.

Lymphoepithelioma-like carcinoma

Lymphoepithelioma

Primary tumor

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Long-term evaluation of extracorporeal shock wave lithotripsy in the treatment of salivary stones

The Journal of Laryngology & Otology (2007)

Suna Schmitz Pamela Zengel Ilija Alvir Michaela Andratschke Alexander Berghaus

Abstract Extracorporeal shock wave lithotripsy is a rather new therapeutical method in the treatment of sialolithiasis. The objective was to evaluate retrospectively the results of the extracorporeal shock wave lithotripsy therapy performed with a Minilith SL 1 lithotripter on 167 out-patients with symptomatic stones (average size 5.94 mm) of the salivary glands over an observation period of seven years. A successful treatment with total stone disintegration was achieved in 51 (31 per cent) patients. In 92 (55 per cent) patients treatment was partially successful, with disappearance of the symptoms but a sonographically still identifiable stone. Treatment failure occurred in 24 (14 per cent) patients who then underwent surgery. The mean follow-up period was 35.6 months (minimum three, maximum 83), after which 83.2 per cent of the initially successfully treated patients were still free of symptoms.Therefore, extracorporeal shock wave lithotripsy, as a non-invasive treatment alternative with few side effects, is an efficient technique for the therapy of sialolithiasis in selected patients.

Extracorporeal

10.1017/s0022215107007396

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Citations (29)

Implantation eines beschichteten Stents bei ösophagotrachealer Fistel: Erste Erfahrung mit einem „Aortenstent”

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren (1997)

F Wacker Suna Schmitz Konrad Schulze P. Klemt C. Höffken

10.1055/s-2007-1015558

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