The aim of the work was to study ureteral mechanism of the urina suppression at women with cancer of the pelvis evisceration and enterocystoplasty before and after course of the estrogens. For local saturation of the estrogens organs of the minor pelvis the women used ovestine vaginal suppositories and the unguent with ovestine (Organon, Holland) on the mucous membrane of the perineum. It was establisced that at patients the application 12 weeks course of estrogens was accompanied by the rise of the volumetrical characteristics of urine flows and the tonic strain lower urinary tract. The use 12-weeks course of the ovestine at these patients improve functional reserves at the urina suppvession.
Clinical and instrumental research showed that a unilateral kidney malignant tumor is often combined with vascular anomalies and atherosclerosis renal artery. For timely revelation of vascular anomalies and renal artery atherosclerosis before operation in patients with kidney cancer tomography and ultrasonography of renal arteries are recommended.
The study was designed to analyse the relationship between EGFR mutation and clinico-pathological features of lung adenocarcinoma in residents of southern Russia taking account oftheir age and sex, localization of the primary tumour, its cell differentiation, regional metastases, stage of disease and smoking status of the patients with mutant and wild-type EGFR genes. The frequency analysis included 29 somatic mutations in EGFR exones 18-21. The study revealed statistically significant associations of EGFR gene mutations with gender, smoking and stage of disease.
Purpose of the study. Was to assess diagnostic informative value of liquid-based cytology optimized with genetic methods for the differential diagnosis of precancerous and malignant diseases of the cervix. Materials and methods. The study included 381 patients. Cervical pathologies were diagnosed with liquid-based cytology only and liquid-based cytology optimized with genetic methods of assessing the expression of miRNA‑20a, miRNA‑375, miRNA‑21 and –23b. Results of liquid-based cytology and genetic methods were verified by histological examination of the material. Statistical analysis was performed using descriptive statistics methods with the calculation of the mean and standard error of the mean. The mean values were compared with the help of the Mann-Whitney test. Results. Diagnostic results of liquid-based cytology were consistent with histological results in 107 (73.8 %) of 145 cervical cancer (CC) patients, in 52 (57.1 %) of 91 patients with high-grade squamous intraepithelial lesions (HSIL), and in 30 (65.2 %) of 46 patients with low-grade squamous intraepithelial lesions (LSIL). Optimization of liquid-based cytology by assessing the expression of miRNA‑21 and miRNA‑23b in the cervical epithelium improved the diagnostic sensitivity of the method from 73.8 % to 80 %, and its specificity from 94.1 % to 97.9 %. The diagnostic sensitivity and specificity of liquid-based cytology for differential diagnosis of CC and HSIL was 87 % and 78.8 %, respectively. Optimization of liquidbased cytology by assessing the expression of miRNA‑20a and miRNA‑375 in the cervical epithelium for the differential diagnosis of CC and HSIL improved the diagnostic sensitivity of the method from 87 % to 95.1 %, and its specificity from 78.8 % to 93.9 %. Conclusions. We revealed the most informative pairs of miRNAs in the cervical epithelium, as an analysis of their expression expanded the possibilities of liquid-based cytology both as a method for diagnosing CC and as a method for the differential diagnosis between CC and HSIL.
Development of ectopic and orthotopic models of human malignant tumors in nude mice with consequent morphologic and immunologic studies was carried out. Morphologic compliancy of tumors having grown in mice to the initial ones was shown. Divergent immunologic changes were found in animals with ectopic and orthotopic tumors.
This article presents a clinical case of a 40-year-old woman with fulminant myocarditis which progressed rapidly to the development of cardiogenic shock resistant to standard intensive care, but with a positive response to extracorporeal membrane oxygenation.
