Laura A. Herndon

Albert Einstein College of Medicine

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

David H. Hall

Albert Einstein College of Medicine

Zeynep F. Altun

Gaziosmanpaşa Taksim Eğitim ve Araştırma Hastanesi

Cathy Wolkow

Johns Hopkins University

Monica Driscoll

Rutgers, The State University of New Jersey

Robyn Lints

Justyna M. Dudaronek

Bioanalytical Systems (United States)

Andrew Fire

Stanford University

Darren Weber

University of California, Davis

Zhuo Du

Institute of Genetics and Developmental Biology

Carolyn Norris

Johns Hopkins University

Cooperative Institutions

Rutgers, The State University of New Jersey

Albert Einstein College of Medicine

Buck Institute for Research on Aging

Johns Hopkins University

University of California, Berkeley

Cornell University

University of Washington

Rutgers Sexual and Reproductive Health and Rights

Yeshiva University

Department of Embryology

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

WormAtlas Glossary - R

WormAtlas (2007)

Laura A. Herndon David H. Hall

Glossary

10.3908/wormatlas.6.18

Cite

Citations (0)

WormAtlas Glossary - Q

WormAtlas (2007)

Laura A. Herndon David H. Hall

Glossary

10.3908/wormatlas.6.17

Cite

Citations (0)

WormAtlas Glossary - E

WormAtlas (2003)

Laura A. Herndon Robyn Lints David H. Hall

Glossary

10.3908/wormatlas.6.5

Cite

Citations (0)

Genetically targeted cell disruption in Caenorhabditis elegans

Proceedings of the National Academy of Sciences (1997)

Singh Harbinder Nektarios Tavernarakis Laura A. Herndon Maud Kinnell Si Qun Xu

The elimination of identified cells is a powerful tool for investigating development and system function. Here we report on genetically mediated cell disruption effected by the toxic Caenorhabditis elegans mec-4 ( d ) allele. We found that ectopic expression of mec-4 ( d ) in the nematode causes dysfunction of a wide range of nerve, muscle, and hypodermal cells. mec-4 ( d )-mediated toxicity is dependent on the activity of a second gene, mec-6 , rendering cell disruption conditionally dependent on genetic background. We describe a set of mec-4 ( d ) vectors that facilitate construction of cell-specific disruption reagents and note that genetic cell disruption can be used for functional analyses of specific neurons or neuronal classes, for confirmation of neuronal circuitry, for generation of nematode populations lacking defined classes of functional cells, and for genetic screens. We suggest that mec-4 ( d ) and/or related genes may be effective general tools for cell inactivation that could be used toward similar purposes in higher organisms.

Genetic screen

10.1073/pnas.94.24.13128

Cite

Citations (76)

WormAtlas Aging Handbook - Introduction to Aging in C. elegans

WormAtlas (2018)

Laura A. Herndon Cathy Wolkow David H. Hall

10.3908/wormatlas.8.4

Cite

Citations (10)

WormAtlas Glossary - B

WormAtlas (2003)