R. Lee Pyle

Virginia–Maryland College of Veterinary Medicine

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Jonathan A. Abbott

Virginia–Maryland College of Veterinary Medicine

Heidi N. MacLean

Virginia–Maryland College of Veterinary Medicine

Donald F. Patterson

University of Pennsylvania

Daniel L. Ward

Rutgers, The State University of New Jersey

E. J. Smith

Institute for Telecommunication Sciences

Donald E. Gregg

Walter Reed Army Institute of Research

Christopher F. Paige

Virginia–Maryland College of Veterinary Medicine

D. David Sisson

University of Illinois Urbana-Champaign

William R. Huckle

Virginia–Maryland College of Veterinary Medicine

Kwaku Barima Gyenai

North Carolina Agricultural and Technical State University

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Virginia Tech

Virginia–Maryland College of Veterinary Medicine

University of Pennsylvania

University of Illinois Urbana-Champaign

Colorado State University

Woods Hole Oceanographic Institution

Institut Français de la Mer

University of Virginia

University of Tennessee at Knoxville

Iowa State University

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Genetic Analysis of Toxin-Induced Dilated Cardiomyopathy in the Turkey (Meleagris gallopavo)

Kwaku Barima Gyenai E. J. Smith CK Larsen F. William Pierson R. Lee Pyle

ABSTRACT Dilated cardiomyopathy (DCM) or round heart disease is a muscle disease of the heart which is characterized by ventricular dilatation and abnormal systolic and diastolic left ventricular function. In animals, including turkeys and humans, DCM is the major cause of morbidity and mortality which results from heart failure. In the turkey, DCM can be idiopathic or induced. Since idiopathic or spontaneous DCM occurs in about 1-4% of normal turkeys, it is of significant concern to the poultry industry. In this study, it was proposed that the incidence and severity of DCM in the turkey may have a genetic basis. To test this hypothesis, I investigated differences in the incidence and severity of DCM in five domesticated turkey varieties including Blue Slate (BS), Bourbon Red (BR), Narragansett (N), Royal Palm (RP) and Spanish Black (SB). Preliminary investigations tested the reliability of echocardiography (ECHO) as a non-invasive and non-destructive technique for diagnosing DCM in a large number of birds from hatch to four weeks-of-age. One-day-old poults for both the preliminary and hypothesis testing investigations were obtained from Privett Hatcheries (Portales, New Mexico). The birds were raised under standard management conditions. In the preliminary investigation and to test my hypothesis, DCM was induced by feeding birds

Meleagris gallopavo

Dilated Cardiomyopathy

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Patent Ductus Arteriosus with Pulmonary Hypertension in the Dog

Journal of the American Veterinary Medical Association (1981)

R. Lee Pyle Richard D. Park A. F. Alexander Brian L. Hill

SUMMARY The clinical, physiologic, and pathologic manifestations of patent ductus arteriosus ( pda ) with pulmonary hypertension (right to left type pda ) were studied in 5 dogs. Cyanosis, hindlimb collapse, low-intensity heart murmurs, and splitting of the 2nd heart sound were prominent clinical findings. Secondary polycythemia was a feature in 3 dogs. Electrocardiography revealed marked frontal plane right axis deviation in all dogs. Radiographic findings in all dogs consisted of an enlarged right ventricle and main pulmonary artery segment, with a hypovascular pulmonary pattern. A wide descending aorta was evident in 4 dogs. Pulmonary arteriography revealed blunt, tortuous secondary and tertiary vessels. Blood flow through the pda was from right to left in 4 dogs and bidirectional in 1. Necropsy of 1 dog revealed extensive pulmonary arterial disease characterized by fibrornuscular intimal proliferation. Surgical correction was contraindicated, and medical therapy was not required in the 4 dogs retained by the owners as pets. Due to the persisting congenital heart defect and the real and potential sequelae, the prognosis is guarded.

Ductus arteriosus

10.2460/javma.1981.178.06.565

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Interpreting low-intensity cardiac murmurs in dogs predisposed to subaortic stenosis

Journal of the American Animal Hospital Association (2000)

R. Lee Pyle

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation RL Pyle; Interpreting low-intensity cardiac murmurs in dogs predisposed to subaortic stenosis. J Am Anim Hosp Assoc 1 September 2000; 36 (5): 379–382. doi: https://doi.org/10.5326/15473317-36-5-379 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search

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10.5326/15473317-36-5-379

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Atrial Fibrillation in Dogs * *Supported in part by Grant USPH HE 4885.

British Veterinary Journal (1971)

F. K. Bohn Donald F. Patterson R. Lee Pyle

10.1016/s0007-1935(17)37336-0

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Citations (34)

Systolic anterior motion of the mitral valve associated with right ventricular systolic hypertension in 9 dogs

Journal of Veterinary Cardiology (2007)

Christopher F. Paige Jonathan A. Abbott R. Lee Pyle

10.1016/j.jvc.2006.08.003

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Citations (18)

Constrictive coxsackie pericarditis.

PubMed (1973)

Rodolphe Ruffy Julian Conrad R. Lee Pyle Mowry Fm

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Candidate Gene Expression Analysis of Toxin-Induced Dilated Cardiomyopathy in the Turkey (Meleagris gallopavo)

Poultry Science (2006)

Kaibo Lin Kwaku Barima Gyenai R. Lee Pyle Tuoyu Geng Jun Xu

Dilated cardiomyopathy (DCM), a heart disease, affects many vertebrates including humans and poultry. The disease can be either idiopathic (IDCM) or toxin-induced (TIDCM). Although genetic and other studies of IDCM are extensive, the specific etiology of TIDCM is still unknown. In this study, we compared mRNA levels of cardiac troponin T (cTnT) and phospholamban (PLN) in turkeys affected and unaffected by TIDCM. Cardiac TnT and PLN were chosen because their altered expression has been observed in IDCM-affected birds. A total of 72 birds, 44 affected and 28 unaffected with TIDCM, were used. Differences in the mRNA levels of cTnT and PLN between affected and unaffected turkeys were significant only for cTnT. The sequence of the turkey PLN showed significant similarity at the nucleotide level to the reference chicken sequence and to those of other species. In addition to implicating cTnT in TIDCM, the present work describes a partial turkey PLN coding sequence that could be useful for future studies.

Troponin complex

Dilated Cardiomyopathy

10.1093/ps/85.12.2216

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Citations (17)

College News

Journal of Veterinary Internal Medicine (1991)

Jeanne A. Barsanti Cleta Bailey Ralph Richardson Mary Crawford R. Lee Pyle

Incoming Program Chairman, on various operational aspects of the 199 1 Forum and discussed plans for future Forums.The Finance Committee and Board had planned on attracting 1400 registrants to New Orleans and were surprised that the total registration exceeded 1600.The New Orleans Marriott was an excellent facility for our meeting, and the registrants appeared to enjoy the French Quarter and other attractions in the New Orleans area.The Speakers' and Moderators' reception at the American Legion Hall in Jefferson, Louisiana, was a big success.The Board has a commitment from Dr. Jack Mara of Hill's Pet Products that the Speakers' and Moderators' Reception in

10.1111/j.1939-1676.1991.tb03141.x

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Balloon Dilation of Double-Chambered Right Ventricle in a Cat

Journal of Veterinary Internal Medicine (2002)

Heidi N. MacLean Jonathan A. Abbott R. Lee Pyle

Balloon dilation

Dilation (metric space)

10.1892/0891-6640(2002)16<478:bdodrv>2.0.co;2

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Hemodynamic effects of orally administered carvedilol in healthy conscious dogs

American Journal of Veterinary Research (2005)

Jonathan A. Abbott Richard V. Broadstone Daniel L. Ward R. Lee Pyle

Abstract Objective —To evaluate the hemodynamic effects of orally administered carvedilol in healthy dogs with doses that might be used to initiate treatment in dogs with congestive heart failure. Animals —24 healthy dogs. Procedure —Dogs were randomly allocated to receive carvedilol PO at a dose of 1.56, 3.125, or 12.5 mg, twice daily for 7 to 10 days; 6 dogs served as controls. Investigators were blinded to group assignment. Hemodynamic variables were recorded prior to administration of the drug on day 1 and then 2, 4, and 6 hours after the morning dose on day 1 and days 7 to 10. Change in heart rate after IV administration of 1 µg of isoproterenol/kg and change in systemic arterial blood pressure after IV administration of 8 µg of phenylephrine/kg were recorded 2 and 6 hours after administration of carvedilol. Results —Administration of carvedilol did not significantly affect resting hemodynamic variables or response to phenylephrine. The interaction of day and carvedilol dose had a significant effect on resting heart rate, but a significant main effect of carvedilol dose on resting heart rate was not detected. Increasing carvedilol dose resulted in a significant linear decrease in heart rate response to isoproterenol. Conclusions and Clinical Relevance —In healthy conscious dogs, orally administered carvedilol at mean doses from 0.08 to 0.54 mg/kg given twice daily did not affect resting hemodynamics. Over the dose range evaluated, there was a dose-dependent attenuation of the response to isoproterenol, which provided evidence of β-adrenergic receptor antagonism. ( Am J Vet Res 2005;66:637–641)

Carvedilol

Phenylephrine

10.2460/ajvr.2005.66.637

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Citations (19)