Ban Jumaa Qasim

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human Colorectal Adenoma and Carcinoma Using Specified Automated Cellular Image Analysis System: A Clinicopathological Study

Oman Medical Journal (2011)

Ban Jumaa Qasim

Objectives: To evaluate the immunohistochemical expression of estrogen receptors (ER) and progesterone receptors (PR) in colorectal adenoma and adenocarcinoma and to correlate this immunohistochemical expression with different clinicopathological parameters.Methods: The study was retrospectively designed.A total of 86 tissue samples, including 33 paraffin blocks from patients with colorectal adenomas, 33 paraffin blocks from patients with colorectal adenocarcinomas and a control group of 20 samples of non-tumorous colonic tissue, were included in the study.Results: The frequency of expression of ER and PR showed a gradual increase from control through adenoma to carcinoma.The frequencies of expression of ER in the control, adenoma and carcinoma were (10%, 15.15% and 42.42% respectively, p<0.001), while the frequency of expression for PR were (10%, 24.24% and 36.36%respectively, p<0.001).Strong ER and PR staining was mainly seen in carcinoma cases (42.42%, 36.36%,respectively) in comparison with adenoma (9.09%, 15.15%, respectively) and control (0%, 0%, respectively).The three digital parameters of ER and PR immunohistochemical expression (Area [A], Number of objects [N], and intensity [I]) were significantly increased in a sequence of normal mucosa-adenoma-carcinoma.There was a significant positive correlation between ER and PR in adenoma (r=0.312,p=0.034) and carcinoma (r=0.321,p=0.0398).Conclusion: ER and PR expression increased in a sequence of; normal colonic mucosa-adenoma-carcinoma, and a positive correlation was observed between ER and PR expression in colonic adenoma and carcinoma specimen indicating that ER and PR may play a role in colorectal carcinogenesis.

Tubular adenoma

Colorectal adenoma

10.5001/omj.2011.78

Cite

Citations (12)

IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN GASTRIC CARCINOMA (A CLINICOPATHOLOGICAL STUDY)

Iraqi journal of Medical Sciences (2008)

Ban Jumaa Qasim Alaa Ghani Hussain Ragheed Sameer Hermiz

Gastric carcinoma

P53 expression

Expression (computer science)

P53 protein

Source

Cite

Citations (2)

The therapeutic effects of apremilast (phosphodiesterase 4 inhibitor) on histological outcome, inflammatory biomarkers and oxidative stress parameter in experimental Induced Colitis

Eurasian Journal of Biosciences (2020)

Hanaa Raheem H. Abdulkareem Ban Jumaa Qasim

Ulcerative colitis (UC) is idiopathic, chronic, relapsing inflammation of the intestines with no effective line of treatment. Therefore, novel and safer drugs with sufficient therapeutic efficacy are needed. The aim of the current study is to investigate the effect of apremilast on histological outcome, inflammatory biomarkers and oxidative stress parameter in experimentally induced colitis. Material and method: Experimental colitis was induced in rats by 4% acetic acid (vol/vol) enemas. Rats with colitis were received either apremilast 25mg/kg or sulfasalazine 100mg/kg orally for 7days. Macroscopical and microscopical assessment and the measurement of the colonic cytokines (IL-4 and TNF-α), oxidative stress marker myeloperoxidase (MPO), and adhesion molecule (E-Selectin). Result: Results showed that both apremilast and sulfasalazine significantly reduced the macroscopical and histological injury in colon that induced by acetic acid. In addition to the downregulation of colonic proinflammatory cytokines, MPO and E-Selectin. Conclusion: These results concluded that artemisinin had effective role in experimental colitis in rats through anti-inflammatory and antioxidant actions with downregulation the colonic adhesive molecule E-Selectin.

Sulfasalazine

Apremilast

Proinflammatory cytokine

Source

Cite

Citations (0)

IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN INVASIVE CERVICAL CARCINOMA (A CLINICOPATHOLOGICAL STUDY)

Iraqi journal of Medical Sciences (2008)

Saif Janan Baythoon Hussam Hasson Ali Ban Jumaa Qasim

P53 expression

P53 protein

Expression (computer science)

Source

Cite

Citations (0)

Sodium Hypochlorite dosage for rainwater harvesting system for potable use in Gambang, Malaysia

Ban Jumaa Qasim Abd Razak Abdul Syukor Md. Nurul Islam Siddique

Rainwater harvesting system for potable use is essential in many parts around the world from the aspects of both sustainable water supply and public health.

Rainwater Harvesting

Potable water

Sodium hypochlorite

Hypochlorite

Source

Cite

Citations (0)

The microbiological quality of harvested rainwater system in a rural area in Malaysia

Ban Jumaa Qasim Abd Razak Abdul Syukor Md. Nurul Islam Siddique Sulaiman Suryati

Malaysia as a developing nation has experiencing a rapid urbanization. In rural and remote areas where access to safe drinking water is limited so that rainwater harvesting is the most common practice to be used as a supplementary resource.

Rainwater Harvesting

Source

Cite

Citations (0)

The impact of floods on safe drinking water supply and sanitation in Southeast Asia: A health priority - review

Ban Jumaa Qasim Abd Razak Abdul Syukor

Floods are the most common natural disasters in the developing countries, approximately 40% of all natural disasters.

Open defecation

Source

Cite

Citations (0)

Immunohistochemical Expression of Ki-67, PCNA and CD34 in Astrocytomas: A Clinicopathological Study

Oman Medical Journal (2012)

Mohammed Kassim Chaloob Hussam Hasson Ali Ban Jumaa Qasim Ahmed Salahaldeen Mohammed

Objectives: To assess the immunohistochemical expression of Ki-67 and Proliferating Cell Nuclear Antigen (PCNA) as proliferative markers to study proliferative activity and CD34 as an endothelial cell marker in order to study vascular proliferation in astrocytomas in correlation with some clinicopathological parameters (age, gender, site of the tumor, and tumor grade).Methods: A retrospective study wherein a total of 51 formalinfixed paraffin-embedded brain astrocytoma excisional biopsies covering the period of June 2009 to February 2011 were retrieved from the archival materials of the Specialized Surgical Hospital in Medical City in Baghdad, Iraq.The histopathological diagnosis had been revised and all cases were stained by immunohistochemical technique with Ki-67, PCNA, and CD34 tumor markers.Values were considered statistically significant when p<0.05.Results: Fibrillary astrocytoma (WHO grade II) was found to be the most common type among astrocytic tumors with the peak age incidence of astrocytomas found in the second and fifth decades of life, and a slight male predominance had been identified.There was a significant correlation between the age of the patients and the grade of the tumor, Ki-67 and PCNA labeling indices, and microvessel density (MVD) detected by CD34 (p<0.05).There was a highly significant correlation between Ki-67 and PCNA labeling indices in astrocytomas (p<0.001).Conclusion: A significant correlation was found between Ki-67, PCNA labeling indices, and MVD (microvessel density) detected by CD34, and between the clinicopathological variables of astrocytomas (age and grade of tumor).Hence, Ki-67 and PCNA, as markers for proliferation, and MVD as a marker of angiogenesis, could be used as ancillary methods in the differentiation of borderline grades of astrocytomas.

Ki-67

Anaplastic astrocytoma

Proliferation Marker

Microvessel

10.5001/omj.2012.93

Cite

Citations (29)

The Microbiological Quality of Harvested Rainwater System for Domestic Use in Gambang, Malaysia

Ban Jumaa Qasim Abd Razak Abdul Syukor Md. Nurul Islam Siddique

The use of roof-collected rainwater as a freely available and sustainable alternative to be used as drinking water that is produced by many drinking water companies around the world is increasing significantly. Malaysia is blessed with an ample supply of water and abundant rains. However, increasing usage by the industry, agriculture and by household users is straining the existing water supply infrastructure. The costs of adding to this infrastructure and that of replacing the ageing system are further burdening Malaysia’s exchequer. At the present, Malaysia depend upon rainwater that falls over hills and countryside, which is collected then into large servitors inside ground as groundwater. Initially, rainwater is free of microbial contamination, but it may become contaminated by animals, surrounding environment that can help pathogens to grow in stored rainwater system and may result in a significant human health risk from infectious diseases. In this study rainwater samples were collected from rainwater Harvesting system tank that is located in a rural area in Gambang at University of Malaysia Pahang. The target microorganism were E. coli and total coliform which were measured by using colilert quanti tray 2000 at the University Environmental Lab. The experiments were performed for 6 months’ period time with different time intervals or which is known as southeast monsoon in Malaysia to evaluate the seasonal change on the microbial parameters variation and their presence in harvested rainwater tank.

Rainwater Harvesting

Source

Cite

Citations (0)

The Protective Effects of Thymus vulgaris Aqueous Extract against Methotrexate- Induced Hepatic Toxicity in Rabbits

Noor Hassoon Swayeh Ahmed R. Abu‐Raghif Ban Jumaa Qasim Hayder B. Sahib

The aim of the study was to investigate the protective effects of aqueous extract of thyme (Thymus Vulgaris) against methotrexate (MTX)-induced toxicity in rabbits. Twenty four rabbits were divided randomly into three groups. Group I was the control group left without treatment, group II was MTX group received a dose of MTX, 20 mg/kg intraperitoneally for three successive days and group III was MTX plus thyme group received a dose of thyme, 500mg/kg orally for 7 days and MTX was given at day three in a dose of 20 mg/kg intraperitoneally for three successive days. After 7 days serum liver function tests were measured then sacrificed and liver tissue homogenate was prepared to evaluate tissue levels of glutathione, malondialdehyde and tumor necrosis factor-α. Also, liver tissue sections were prepared and stained for histological evaluation. Administration of thyme extract significantly decreased the elevated levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) and significantly increased the lowered levels of total protein and albumin in the serum compared to MTX-treated group. It also elevates Glutathione (GSH) and decreases Malondialdehyde (MDA) and Tumor Necrosis Factor-alpha (TNF-α) tissue levels significantly compared to MTX treated group; this was associated with improving histological features that impaired during MTX exposure. Thyme extract protects hepatic tissue against MTX-induced liver damage.

Malondialdehyde

Source

Cite

Citations (15)