MJ. Rodriguez-Tojo

University of the Basque Country

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José Manuel Aguirre Urízar

University of the Basque Country

Francisco Barros

Fundación Pública Galega de Medicina Xenómica

Mercedes Gallas

Universidade de Santiago de Compostela

Abel Garcı́a Garcı́a

Hospital Universitario Infanta Sofía

JC. Coca-Meneses

University of the Basque Country

José Manuel Suárez Peñaranda

Universidade de Santiago de Compostela

DA. Cortes-Ramirez

University of the Basque Country

Xabier Marichalar‐Mendía

University of the Basque Country

Mario Pérez‐Sayáns

Universidade de Santiago de Compostela

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Instituto de Investigación Sanitaria de Santiago

Universidade de Santiago de Compostela

University of the Basque Country

Servicio Gallego de Salud

Centro de Cirugía de Mínima Invasión Jesús Usón

Complejo Hospitalario Universitario de Santiago

National Medical Research Center of Dentistry and Maxillofacial Surgery

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Centre for Biomedical Network Research on Rare Diseases

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The use of tissue microarrays for semiquantitative evaluation of ATPaseC1 expression is ineffective

Biotechnic & Histochemistry (2015)

Mario Pérez‐Sayáns José Manuel Suárez Peñaranda José Manuel Aguirre Urízar MJ. Rodriguez-Tojo Francisco Barros

We described earlier the possible role of ATPaseC1 expression as a diagnostic and prognostic marker for oral cancer; others have reported its use for tumors of the lung and breast. We assessed ATPaseC1 expression in a sample of oral squamous cell carcinoma (OSCC) using tissue microarrays (TMAs) to analyze the relation between ATPaseC1 expression and clinical, histopathological and prognostic parameters. We performed a retrospective study of 48 cases of OSCC. We constructed TMAs using two different regions of each tumor. V-ATPaseC1 immunohistochemistry was performed and assessed semiquantitatively. ATPaseC1 staining was observed in most of the neoplastic cells in all tumors. Staining was diffusely cytoplasmic and, to a lesser extent, nuclear. The degree of concordance between the measurements performed in tissue microarray 1 (TMA1) and tissue microarray 2 (TMA2), as evaluated using the intra-class correlation coefficient (ICC), was low. We found great variability in the immunohistochemical staining of the different regions of each tumor. We found 16 cases with mild expression (33.3%), 20 with moderate expression (41.7%) and 12 with intense expression (25%). Differences in the clinical-pathological variables studied were not statistically significant. The difficulty of immunohistochemical evaluation, the heterogeneity of the carcinomas and the fact that evaluation of expression requires semiquantitative analysis render the reliability of the results obtained from TMA-based techniques questionable.

Tissue microarray

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Anatomical pathology

10.3109/10520295.2015.1023357

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Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease

Medicina oral, patología oral y cirugía bucal (2014)

DA. Cortes-Ramirez MJ. Rodriguez-Tojo JC. Coca-Meneses Xabier Marichalar‐Mendía José Manuel Aguirre Urízar

The oral lichenoid disease (OLD) includes different chronic inflammatory processes such as oral lichen planus (OLP) and oral lichenoid lesions (OLL), both entities with controversial diagnosis and malignant potential.Epidermal growth factor receptor (EFGR) is an important oral carcinogenesis biomarker and overexpressed in several oral potentially malignant disorders.Objectives: To analyze the EGFR expression in the OLD to find differences between OLP and OLL, and to correlate it with the main clinical and pathological features.Material and Methods: Forty-four OLD cases were studied and classified according to their clinical (Group C1: only papular lesions / Group C2: papular and other lesions) and histopathological features (Group HT: OLP-typical / Group HC: OLP-compatible) based in previous published criteria.Standard immunohistochemical identification of EGFR protein was performed.Comparative and descriptive statistical analyses were performed.Results: Thirty-five cases (79.5%) showed EGFR overexpression without significant differences between clinical and histopathological groups (p<0.05).Histological groups showed significant differences in the EGFR expression pattern (p=0.016).Conlusions: All OLD samples showed high EGFR expression.The type of clinical lesion was not related with EGFR expression; however, there are differences in the EGFR expression pattern between histological groups that may be related with a different biological profile and malignant risk.

Oral Lichen Planus

Clinical Significance

10.4317/medoral.19452

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Citations (7)