J. P. Gregersen

Novartis (Germany)

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S. Mehdi

Behringwerke (Germany)

J. Hilfenhaus

Behringwerke (Germany)

H. Ludwig

Chongqing Medical University

F. Grendel

Georg Pauli

Robert Koch Institute

Maren Eggers

Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer

F. Feigl

Andreas S. Baur

Comprehensive Cancer Center Erlangen

Gertrud Klepetar

Medisch Centrum Haaglanden

L. Grimbert

Cooperative Institutions

Behringwerke (Germany)

University Medical Center Hamburg-Eppendorf

Universität Hamburg

Friedrich-Alexander-Universität Erlangen-Nürnberg

Robert Koch Institute

Institute of Virology of the Slovak Academy of Sciences

Friedrich-Loeffler-Institut

University of Giessen

Freie Universität Berlin

Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer

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Antibody‐ and complement‐mediated lysis of HIV‐infected cells and inhibition of viral replication

Journal of Medical Virology (1990)

J. P. Gregersen S. Mehdi Andreas S. Baur J. Hilfenhaus

Abstract HIV‐1‐positive antisera were tested for their ability to lyse HIV‐1‐infected cells in the presence of active complement. Cytolytic effects caused by sera derived from infected humans were slower than those observed with sera from immunised chimpanzees. Lytic but also negative sera were found among HIV‐1‐infected asymptomatic men as well as among clinical AIDS cases. Human antisera that lysed infected cells reacted similarly irrespective of whether the complement was heterologous or autologous. Analysis of complement‐mediated lysis using defined antisera against recombinant HIV‐1 env or core antigens suggested that gp 160/gp 120 and p24 can act as target antigens for an antibody‐ and complement‐mediated cytolysis of infected cells. Complement alone reduced the spread of HIV‐1 infection in CD4 + cells and the ability of HIV‐1 and HIV‐2 to form plaques in CD4‐transfected HeLa cells. Co‐operative effects of specific antibodies and complement were the most effective in inhibiting HIV infections.

Heterologous

Lytic cycle

10.1002/jmv.1890300411

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Citations (23)

Adaptation of hepatitis A virus to high titre growth in diploid and permanent cell cultures

Medical Microbiology and Immunology (1988)

J. P. Gregersen S. Mehdi R. Mauler

WI-38

Vero cell

Immunoperoxidase

10.1007/bf00189530

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Citations (7)

Environmental product declarations for telecommunication products

Jens Brøbech Legarth Stig Hirsbak J. P. Gregersen Hanne K. Linnet Erichsen E. Borch

Several types of voluntary environmental claims have been developed during the last decade in response to a growing demand by public and commercial customers for insight into product life cycle environmental performance. Now almost fully standardized by the ISO 14020 series, these voluntary environmental claims appear as eco-labels and a variety of environmental declarations. This paper discusses a project underway in collaboration with Denmark's largest telecommunication services provider, Tele Danmark A/S, which also sells telecommunication electronics from a chain of stores throughout Denmark. The project is aimed at establishing a green procurement framework and to install environmental product declarations as a green marketing tool, in a way that links these two disciplines together into a streamlined information flow.

Telecommunications service

Telecommunications equipment

10.1109/isee.2000.857657

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Citations (1)

Immune response of chimpanzees after immunization with the inactivated whole immunodeficiency virus (HIV-1), three different adjuvants and challenge

Vaccine (1993)

Matthias Niedrig J. P. Gregersen Patricia N. Fultz Michael Bröker S. Mehdi

Humoral immunity

Cellular immunity

10.1016/0264-410x(93)90341-t

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Citations (23)

Heat inactivation of human immunodeficiency virus type 2 (HIV-2)

Journal of Biological Standardization (1989)

J. P. Gregersen J. Hilfenhaus John F. Lemp

10.1016/s0092-1157(89)80009-5

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Citations (12)

A CD 4: immunoglobulin fusion protein with antiviral effects against HIV

Archives of Virology (1990)

J. P. Gregersen S. Mehdi Huub C. Gelderblom G. Zettlmei�l

Medical microbiology

10.1007/bf01310503

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Citations (10)

Do specific hyperimmunoglobulins aggravate clinical course of tick-borne encephalitis?

The Lancet (1996)

Cornelia Arras Reinhard Fescharek J. P. Gregersen

Tick-borne encephalitis

Course (navigation)

10.1016/s0140-6736(96)90977-0

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Citations (27)

Inactivation of retroviruses in biologicals manufactured for human use.

PubMed (1991)

J. Hilfenhaus J. P. Gregersen Helena Müller-Kräuter T Nowak W. Pranter

Human immunodeficiency virus may occur in human plasma and mammalian retroviruses in established cell lines used for the production of monoclonal antibodies or recombinant proteins. To avoid any risk of retrovirus infections being transmitted to human patients by human plasma proteins or other biologicals obtained from established cell lines, these products must be free of contaminating retroviruses. This can be achieved by excluding contaminated source material and by establishing manufacturing procedures which inactivate and eliminate retroviruses. Some methods were investigated, and it was proved that these methods not only completely inactivate retroviruses, but that they are at the same time mild enough not to destroy the biological activities of the substances to be used as therapeutics. In addition, the clearance of retroviruses by the entire manufacturing process of an immunoglobulin, human plasminogen, a murine monoclonal antibody and a recombinant human protein were studied. In each case cumulative clearance factors of greater than 10(12) were achieved for the retroviruses used in these spiking experiments. It can be concluded that these high clearance factors contribute a very high margin of safety to the biologicals manufactured.

Source

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Citations (7)

Untersuchungen über die Magensekretion während des Verlaufes der Verdauung

Digestion (1913)

J. P. Gregersen

10.1159/000192976

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Citations (5)

Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis: BHV-1 infections

Revue Scientifique et Technique de l OIE (1986)

H. Ludwig J. P. Gregersen

Infectious bovine rhinotracheitis

Herpesviridae Infections

10.20506/rst.5.4.272

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Citations (17)