// Úna C. McMenamin 1 , James Trainor 2 , Helen G. Coleman 5 , Damian T. McManus 2 , Stephen McQuaid 3 , Victoria Bingham 3 , Jacqueline James 3 , Manuel Salto-Tellez 3 , Brian T. Johnston 4 and Richard C. Turkington 5 1 Cancer Epidemiology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK 2 Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK 3 Northern Ireland Molecular Pathology Laboratory, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, UK 4 Department of Gastroenterology, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK 5 Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, UK Correspondence to: Úna C. McMenamin, email: u.mcmenamin@qub.ac.uk Keywords: estrogen receptor; androgen receptor; esophageal adenocarcinoma; survival; recurrence Received: June 18, 2018 Accepted: October 06, 2018 Published: October 19, 2018 ABSTRACT Introduction: A striking epidemiological feature of esophageal adenocarcinoma (EAC) is its strong, unexplained male predominance but few studies have evaluated the prevalence of sex hormone receptor expression in EAC. Results: A low proportion of EAC tumors stained positive for ERα (4%) and AR (3%) while approximately one third stained positive for ERβ (31%). After a mean follow-up of 3 years (max 9 years), no significant associations were seen for ERα, ERβ or AR expression and EAC recurrence or survival. A non-significant reduction in mortality was observed for positive ERβ tumor expression, when restricting to patients with gastro-esophageal junctional (GEJ) cancer (HR 0.58, 95% CI 0.33, 1.03, p = 0.06). Materials and Methods: We identified all EAC patients who underwent neo-adjuvant chemotherapy prior to surgical resection between 2004–2012 in the Northern Ireland Cancer Centre. Immunohistochemical expression of ERα, ERβ and AR was scored on triplicate cores to generate H-scores. Cox proportional hazards regression was used to evaluate the association between sex hormone receptor expression and overall, cancer-specific and recurrence-free survival. Conclusion: We found little evidence of ERα or AR expression in EAC. A moderate proportion expressed ERβ and there was suggestive evidence that its expression was associated with improved survival in GEJ cancer patients.
This paper is divided into two sections. In the first, attention is drawn to three categories of rhetorical device described in the commentary to the Amrae Coluimb Chille, all of which involve some form of repetition. This is the starting point for a discussion of the artful use of repetition in Early and Classical Modern Irish literature. Examples of such repetition and parallel phrasing are provided for both periods. In the Classical period this inevitably involves some discussion of breacadh, a metrical and stylistic ornament involving repetition. In the second section, the focus moves to parallel phrases based on antithesis (such as English ‘the Lord giveth, the Lord taketh away’) or contrast. The antonymy may be conveyed lexically (as in the example just quoted, ‘give’ vs ‘take’) or antithesis may be created morphologically (through a contrast of tense and voice, for instance, gonas géntair ‘he who kills will be killed’). The make-up of these antonymous parallel phrases will be described, the types of antithesis encountered discussed and questions of their interpretation addressed. A collection of Early Irish and Classical Modern Irish examples concludes the paper.
VARIA I IGT citations and duplicate entries;furtheridentifications In a brief varium in volume 51 of this journal' a number of quotations in the grammatical and syntactical tracts identified in published and unpublished Bardic poetry were added to those previously collected by me2and supplemented by Padraigde Brtn.3 Thanks to contributions from Dr Katharine Simms (S), Dr Eoin Mac Ctrthaigh (Mac C) and Eoghan 6 Raghallaigh(0 R), I amnow able to adda further27 suchcitations,together with a further 4 noted by Professor PaidraigBreatnach4(B), bringing the overall total to 434.The total numberof poems in whichcitations have been found now runsto 173 (previously 160).5 (161) *Cr6udtarraightreisi Connacht (Maoilsheachluinnna nUirsg6l 0 hUiginn), 2 (> 3) (Book of O'Conor Don, 321a ff:13cd = IGT II 2092;25ab = IGT II 301 (B). (162) Cuimhnighleat meise, a Mhurchaidh,3 (RIA 1387,41 ff: 16cd = IGT II 498;617cd= BST 228.21-2/17b1;30cd = IGT III 136). (155) *Cumhaidhfocas on6ir riogh, 1 (> 3) (Book of O'Conor Don, 360a ff:17cd = IGT III 278) (B). (163) Da gridh do fhagbhasIirinn (TadhgCamchosach0 Dalaigh?), 1 (MeasgraDdnta II no. 49:25cd = IGT III 167) (B). I Damian McManus, 'Varia IV: IGT citations and duplicate entries: some additional identifications',triu 51 (2000) 193-4. 2 Damian McManus, 'The Irish grammatical and syntactical tracts: a concordance of duplicated and identified citations', Iriu 48 (1997), 83-101. 3 Padraig de Brdn, 'Varia IV: IGT citations-some additional identifications', IPriu49 (1998), 175-6. 4 PAdraigA. Breatnach, 'The metres of citations in the Irishgrammaticaltracts', tigse 32 (2000), 7-22:14 n. 28. ' Poems previously cited are given their original numbers and marked with an asterisk. The new total of citations fromsuch poems is indicated after the firstline (or name of poet, as appropriate) in the form '1 (> 6)', i.e.one additional citation,bringingthe total from the poem to six. Special thanks are due to Mr Eoghan 0 Raghallaigh,Ms Kay Saundersand Mr Muiris 6 Raghallaigh who, as research assistants on the HEA-sponsored Irish-Scottish Academic Initiative's Bardic Project,are responsible for transcribingthe unpublished poems referred to here. 6 The text recorded in RIA 1387 (Ni dilios duit a-deir breath / crodh acht a ccuire ar th'eineach/ dilios dod bharrglan geagchas / an cradh an tan[n]tidhldacfas'According to legal ruling the only wealth which remains your property is that which you invest in your honour; when one bestows one's wealth [on poets] it remains the property of your bright curled and branchinghair') contains a most irregular2ndsg.dod bharrwitha 3rdsg verbtidhldacfas(with irregulardouble future marking,e andf, the rhyme requirestidhlhacas).The version in IGT III 498 (Diles dd barrglan gigcas, a chradan tann tidhltcas) resolves this difficulty,but leaves us with a quatraincontaining agallamh in ab andfaisneis in cd. triu LIV(2004) 249-251 @ Royal IrishAcademy 250 DAMIAN McMANUS (164) Do-chi6imeirge catha Cuinn, 1 (RIA 703 (23 H 8), 51v ff: 10ab = IGT II 70; 10cd = IGT II 71)7'(S). (64) *Do t6gbhadh meirge Murchaidh(Gofraidh Fionn 0 Dalaigh), 1 (> 6) (Dioghluim Ddna 85:16cd = IGT III 653) (Mac C). (165) Gach sfol go siol rioghEoghain, 1 (TCD 1363,130 ff: 1193-4 = IGT II 1078) (MacC). (166) Grian tsamhraidhteist Tomhaltaigh(Seithfin M6r), 1 (TCD 1363,132 ff:11107-8 = IGT II 1344). (167) Mairgas fhial tar 6is Cormaic (Maolmhuire Bacach Mac Craith),3 (Book of O'Conor Don, 358b ff: lcd = IGT IV 1019 (6 R); 23cd = IGT II 1197;41cd = IGTII 726). (168) M'anamdhuit a Dh6 athar,3 (Book of O'Conor Don, 120aff: 12ad = IGT II 902,23ad = BST 223.2-3/13b11/44a8; 36cd = IGT II 11312). (105) *Na tri Cholla Clann Eathach, 1 (> 2) (RIA 744 (A v 2), 59a ff:8cd = BST238.6). (169) Nifth6id caithemh a ccloinn Taiil,1 (Book of O'Conor Don, 297b ff: 12cd = IGT I 80b) (B). (170) Rainig s6ala ar shith Uladh, 2 (TCD 1378,272 ff: 10cd= IGT IV 1022;28cd = BST 29b17). (171) Shindona saoithibh sealga (Gofraidh Fionn 6 Dalaigh?),"2 (Franc.A25, 166ff: llcd = BST 189.19/8a3/Da29 (S);9 17cd= IGT III 251). (172) Tainig an trith n6na (Maoilsheachlainn 0 hUiginn), 1 (Irish Syllabic Poetry,33...
This paper is one in a series investigating women in Classical Irish poetry. The subject on this occasion is the patron’s wife. The paper examines how a married woman is addressed and/or referred to in the poetry and surveys the qualities most frequently praised in the iargcomhairc or complimentary verses addressed to the patron’s wife. The interest shown by women in the poets’ work is assessed, as is the question of whether there is a separate discourse for the praise of women. The paper concludes with a brief survey of a small number of poems addressed to married couples.
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