Tom S. Miya

Purdue University West Lafayette

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William F. Bousquet

Purdue University West Lafayette

R. Schnell

Karolinska Institutet

John H. Mennear

Campbell University

William J. Kinnard

Colorado Permanente Medical Group

John E. Christian

University of Oregon

Billy D. Rupe

Burroughs Wellcome Fund

Jeffrey R. Means

California State University, Fresno

Craig Schnell

University of Nebraska Medical Center

Anthony Kales

Pennsylvania State University

William M. Hadley

University of New Mexico

Cooperative Institutions

Purdue University West Lafayette

National Institutes of Health

University of Utah

Pennsylvania State University

Penn State Milton S. Hershey Medical Center

University of New Mexico

University of Michigan–Ann Arbor

Indiana University – Purdue University Indianapolis

University of Kentucky

Université de Montréal

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Journal of Pharmaceutical Sciences (1972)

Tom S. Miya

10.1002/jps.2600610648

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Citations (0)

Metabolism of Phenothiazine Drugs

Journal of Pharmaceutical Sciences (1963)

John L. Emmerson Tom S. Miya

10.1002/jps.2600520503

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Citations (33)

Kinetics of cadmium-induced hepatic and renal metallothionein synthesis in the mouse

Toxicology and Applied Pharmacology (1977)

Gregory S. Probst William F. Bousquet Tom S. Miya

Metallothionein

10.1016/0041-008x(77)90176-4

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Citations (65)

ALTERED ABSORPTION OF DRUGS FROM THE RAT SMALL INTESTINE BY CARBONIC ANHYDRASE INHIBITION

Journal of Pharmacology and Experimental Therapeutics (1970)

R. Schnell Tom S. Miya

The absorption of C14-dextroamphetamine sulfate, C14-salicylic acid and C14-urea from in vivo intestinal loops located either in the duodenum or ileum in male rats was determined after pretreatment with acetazolamide. In the ileum, after acetazolamide the absorption of d -amphetamine was decreased, that of salicylic acid was increased and that of urea was unchanged. The pH of the ileal contents was more acidic after acetazolamide. Plasma levels generally reflected the absorption of the respective compound. In the duodenum, after acetazolamide the absorption of d -amphetamine was increased, that of salicylic acid was decreased and that of urea was unchanged. The pH of the duodenal contents was not changed after acetazolamide. Again, plasma levels generally reflected the absorption of the respective compound. Tissue binding of each drug within the two intestinal tissues did not differ after acetazolamide. Carbonic anhydrase assays revealed that the acetazolamide treatment abolished enzyme activity in the intestinal tissue. The differential absorption pattern of the acidic and basic drug from duodenal and ileal sites suggests that the alterations in absorption were secondary physiologic changes resulting from carbonic anhydrase inhibition.

Acetazolamide

10.1016/s0022-3565(25)28607-4

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Citations (10)

Biases and Perceptions Versus Reality

American Journal of Pharmaceutical Education (1985)

Tom S. Miya

10.1016/s0002-9459(24)09957-1

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Citations (1)

Histamine disposition in the hypertensive rat

Life Sciences (1974)