J BASKERVILLE

Western University

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Papers

Citation

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i-10 index

Research Field

A comparison of sporadic and familial multiple sclerosis

Neurology (1990)

Brian G. Weinshenker Dennis E. Bulman W. Carriere J BASKERVILLE George C. Ebers

We compared demographic and clinical features, including outcome defined by a failure time analysis of disability, in 143 patients with a family history of multiple sclerosis (familial MS) compared with 956 patients without such a history (sporadic MS). Patients with familial MS did not differ from those with sporadic MS even when patients with 1st-degree relatives or multiple relatives with MS were considered separately. An intraclass correlation analysis of 13 pairs of affected 1st-degree relatives, both members of which were followed in our clinic, failed to reveal heterogeneity among different families. We were unable to find any support for differences between familial and sporadic MS.

First-degree relatives

10.1212/wnl.40.9.1354

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Citations (63)

Sparingly-soluble narcotic zinc tannates cause protracted analgesia in rats

Neuropharmacology (1980)

Bruna Brands J BASKERVILLE R G Herne Maurice Hirst C. W. Gowdey

Narcotic

Narcotic antagonists

10.1016/0028-3908(80)90051-9

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Citations (2)

A Systematic Study of the Consulting Literature as an Integral Part of Applied Training in Statistics

The American Statistician (1981)

J BASKERVILLE

Abstract Seven important topics in statistical consulting are suggested as focal points for a study of the consulting literature. We have found that reading and discussing a few papers relevant to each topic, and considering how these topics are related, can be meaningfully integrated into training applied statisticians.

Statistical Analysis

10.1080/00031305.1981.10479326

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Citations (15)

In vitro studies of microwave-induced cataract: Reciprocity between exposure duration and dose rate for pulsed microwaves

Experimental Eye Research (1985)

P.J. Stewart-DeHaan M.O. Creighton Lars Erik Larsen J.H. Jacobi M. Sanwal

Pulse duration

Specific absorption rate

10.1016/0014-4835(85)90103-4

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Citations (26)

685 Effects of budesonide (BUD) dose and dosing schedule on skeletal metabolism

Journal of Allergy and Clinical Immunology (1991)

J TOOGOOD Barbara Jennings Anthony B. Hodsman L. J. Fraher J BASKERVILLE

10.1016/0091-6749(91)91967-x

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Citations (1)

The Trendelenburg Position

Survey of Anesthesiology (1980)

William J. Sibbald N. A. Paterson R. L. Holliday J BASKERVILLE

SIBBALD, W. J.; PATERSON, N. A. M.; HOLLIDAY, R. L.; BASKERVILLE, J. Author Information

Trendelenburg position

Trendelenburg

Position (finance)

10.1097/00132586-198004000-00032

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Citations (0)

Bone mineral density and the risk of fracture in patients receiving long-term inhaled steroid therapy for asthma

Journal of Allergy and Clinical Immunology (1995)

J TOOGOOD J BASKERVILLE Alexander Markov Anthony B. Hodsman L FRAHER

Cumulative dose

10.1016/s0091-6749(95)70003-x

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Citations (122)

Clinical trials designed to evaluate therapeutic preferences

Statistics in Medicine (1984)

J BASKERVILLE J TOOGOOD Jorge Mazza Barbara Jennings

Abstract We present an experimental design for the evaluation of therapeutic preferences among well established similar modes of therapy. The measure of the degree of preference is based on clinical decisions to continue or discontinue the current treatment at each patient visit. Such a trial simulates decision‐making in ordinary clinical practice, while adhering to the scientific principles of experimental design, and it alleviates some of the ethical problems inherent in randomized allocation of a treatment for a period of fixed length in conventional controlled trials. We discuss the design and methods of analysis and illustrate their application with data from a trial comparing three alternative drug treatments for chronic asthma. Such clinical trials provide a mechanism for examining concordance between the relative efficacy of treatments predicted from conventional controlled clinical trials and their ultimate performance in ordinary clinical practice, expressed in terms of therapeutic preferences.

Concordance

Clinical Practice

10.1002/sim.4780030107

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Citations (12)

Personal observations on the use of inhaled corticosteroid drugs for chronic asthma.

PubMed (1984)

Toogood Jh Barbara Jennings J BASKERVILLE Lefcoe Nm

Topically active inhaled corticosteroid (IC) drugs are highly effective for chronic asthma. Formalized conceptions of "high, low or safe" dosages of these drugs may be less appropriate than one of "optimal dosage". It seems reasonable to formulate a specific goal of treatment, and then fit dosage to the individual needs and tolerances of the patient rather than to a conventionalized "safe" limit, based on averaged data from different and perhaps quite dissimilar subjects. The studies reviewed here illustrate some principles applicable to the effective use of IC drugs.

Dose

Source

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Citations (27)

Association of ocular cataracts with inhaled and oral steroid therapy during long-term treatment of asthma

Journal of Allergy and Clinical Immunology (1993)

J TOOGOOD Alexander Markov J BASKERVILLE Charles Dyson

Cumulative dose

10.1016/0091-6749(93)90263-f

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Citations (107)