Mohammad Akbar Khuroo

University of Kashmir

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Khursheed Ahmad Bhat

Indian Institute of Integrative Medicine

Shabir H. Lone

Indian Institute of Integrative Medicine

Mudasir A. Tantry

Cluster University Srinagar

Bashir Ahmad Dar

Sher-i-Kashmir Institute of Medical Sciences

Baldev Singh

Sardar Vallabhbhai Patel University of Agriculture & Technology

Mohsin Ahmad Bhat

Columbia University

A. S. Shawl

Indian Institute of Integrative Medicine

Ram A. Vishwakarma

Council of Scientific and Industrial Research

Khaliquz Zaman Khan

University of Kashmir

Naheed Sidiq

Qatar University

Cooperative Institutions

Indian Institute of Integrative Medicine

University of Kashmir

Council of Scientific and Industrial Research

Academy of Scientific and Innovative Research

Regional Research Institute of Unani Medicine

University of Jammu

Central Council for Research in Unani Medicine

Sher-i-Kashmir Institute of Medical Sciences

Cluster University Srinagar

National Institute of Technology Srinagar

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Comparative analysis of the aroma chemicals of Melissa officinalis using hydrodistillation and HS-SPME techniques

Arabian Journal of Chemistry (2013)

Shakeel-u- Rehman Romaisa Latief Khursheed Ahmad Bhat Mohammad Akbar Khuroo A. S. Shawl

Headspace solid-phase micro extraction (HS-SPME) coupled with gas chromatography–mass spectrometry (GC–MS) has been used for the chemical analysis of Melissa officinalis (leaves) cultivated in Institute Germplasm. The HS-SPME analysis led to the identification of 22 components constituting 99.1% of the total volatile constituents present in the leaves whereas its hydrodistillate led to the identification of 24 volatile constituents constituting 98.1% of the volatile material. The chemical composition of the SPME and hydrodistilled extract of M. officinalis leaves comprised mainly of oxygenated monoterpenes (78.5% and 57.8% respectively) and sesquiterpene hydrocarbons (14.9% and 29.7% respectively). The major components identified in the HS-SPME extract were citronellal (31.1%), citronellol (18.3%), β-caryophyllene (12.0%), (E)-citral (11.9%), (Z)-citral (9.6%), geraniol (3.6%), (Z)-β-ocimene (3.1%) and 1-octen-3-ol (2.0%) whereas hydrodistilled essential oil was rich in (Z)-citral (19.6%), β-caryophyllene (13.2%), (E)-citral (11.2%), citronellal (10.2%), germacrene-d (8.3%), δ-3-carene (5.0%), 6-methyl-5-hepten-2-one (3.7%) and citronellyl acetate (3.7%). The comparative analysis of volatile constituents of M. officinalis leaf extract using HS-SPME and hydrodistillation techniques shows both qualitative as well as quantitative differences. The current study is the first report involving rapid analysis of volatile components of M. officinalis by HS-SPME.

Citronellal

Citral

Melissa Officinalis

Citronellol

Nerol

Solid-Phase Microextraction

Geranyl acetate

Caryophyllene

Nonanal

Decanal

10.1016/j.arabjc.2013.09.015

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Citations (40)

Ultrasound promoted expeditious, catalyst-free and solvent-free approach for the synthesis of N,N′-diarylsubstituted formamidines at room temperature

Tetrahedron Letters (2013)

Bashir Ahmad Dar Syed Naseer Ahmad Mohammad Arif Wagay Altaf Hussain Nisar Ahmad

Environmentally Friendly

Organic Synthesis

10.1016/j.tetlet.2013.06.131

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Citations (22)

Biological Profile of Artemisia amygdalina

SpringerBriefs in pharmacology and toxicology (2015)

Shabir H. Lone Khursheed Ahmad Bhat Mohammad Akbar Khuroo

Vernonia amygdalina

Petroleum ether

Carrageenan

Artemisia

Anti-inflammatory

10.1007/978-3-319-25217-9_5

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Citations (0)

Volatile Composition of Artemisia amygdalina

SpringerBriefs in pharmacology and toxicology (2015)

Shabir H. Lone Khursheed Ahmad Bhat Mohammad Akbar Khuroo

Borneol

Camphene

Sabinene

Monoterpene

Eucalyptol

Camphor

Terpene

10.1007/978-3-319-25217-9_3

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Phytochemical and Cytotoxic Evaluation of Peganum Harmala: Structure Activity Relationship Studies of Harmine

ChemistrySelect (2017)

Iram Ayoob Younis Hazari Shabir H. Lone Shakeel-u-Rehman Mohammad Akbar Khuroo

Four alkaloid constituents: harmine, vasicine, vasicinone and harmaline were isolated and characterized from Peganum harmala roots. Harmine showed the best cytotoxicity with IC50 of 32, 106, 45, 33 and 61 μM against breast (HBL-100), lung (A549), colon (HT-29 & HCT-116) and cervical (HELA) cells respectively. The harmine analogs, synthesized via click chemistry, revealed that few derivatives possess potent cytotoxic effects. m-Fluoro phenyl-1, 2,3-triazolyl harmine was found to be selectively cytotoxic against human breast cancer cell lines only displaying an IC50 of 16μM. p-Fluoro phenyl-1,2,3-triazolyl harmine and p-methoxy phenyl-1,2,3-triazolyl harmine displayed improved cytotoxicity. p-Fluorophenyl-1,2,3-triazolyl harmine displayed broad spectrum cytotoxic effects against all the tested cancer-cell lines with IC50 of 17, 19, 29 and 17μM against lung (A-549), Colon (HT-29), Cervic (HELA) and Colon (HCT-116) cell lines respectively while as p-methoxy phenyl-1,2,3-triazolyl harmine showed selectivity towards lung and colon cancer cell lines with IC50 of 27, 18 and 17μM against A549, HT-29 and HCT-116 respectively.

Harmine

Peganum harmala

HeLa

IC50

Phytochemical

10.1002/slct.201700232

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Citations (55)

Bioactivity‐Guided Isolation, Antimicrobial and Cytotoxic Evaluation of Secondary Metabolites from Cladosporium tenuissimum Associated with Pinus wallichiana

ChemistrySelect (2017)

Syed Naseer Khursheed Ahmad Bhat Masroor Qadri Syed Riyaz‐Ul‐Hassan Fayaz Malik

Abstract Cladosporium tenuissimum, an endophyte, was isolated from Pinus wallichiana growing in the Western Himalayas of Lolab Valley (Kashmir India) and analysed for its secondary metabolite composition. Column chromatography of the culture broth lead to the isolation of three bioactive molecules viz; (3 S , 5 S , 11 S )‐trihydroxydodecanoic acid, scytalone and o‐hydroxyphenyl acetone. The stereochemistry of (3 S , 5 S , 11 S )‐trihydroxydodecanoic acid was deduced from pandangolide. Pandangolide has been isolated from Cladosporium species and its stereochemistry is known. The isolated constituents were evaluated for cytotoxic and antimicrobial potential against MCF‐7, T47D, MDA‐MB‐231 cell lines and ATCC 29213, ATCC 25922, IIIM 25, MTCC 4748 strains. (3 S , 5 S , 11 S )‐trihydroxydodecanoic acid exhibited significant cytotoxic activity against the human breast cancer cell line (MCF‐7) with an IC 50 of 15 μg/ml. o‐Hydroxyphenyl acetone displayed prominent antimicrobial activity against Bacillus cereus IIIM 25 (Gram positive) and Escherichia coli ATCC 25922 (Gram negative) with IC 50 of 23.3μg/ml and 43.7μg/ml respectively. o‐Hydroxyphenyl acetone is being reported for the first time from any natural source while as (3 S , 5 S , 11 S )‐trihydroxydodecanoic acid and scytalone for the first time from C. tenuissimum .

Cladosporium

Secondary metabolite

Endophyte

10.1002/slct.201601942

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Citations (6)

ChemInform Abstract: Iodine Catalyzed Solvent‐Free Cross‐Dehydrogenative Coupling of Arylamines and H‐Phosphonates for the Synthesis of N‐Arylphosphoramidates under Atmospheric Conditions.

ChemInform (2014)

Bashir Ahmad Dar Nisar A. Dangroo Amit Kumar Gupta‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬Aarti Wali Mohammad Akbar Khuroo

10.1002/chin.201431189

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Citations (0)