Summary Metaplastic breast carcinoma is uncommon and constitutes less than 5% of all breast cancers. The cancerous epithelium becomes non‐glandular through metaplastic differentiation. There are various subtypes and the extent to which this process occurs varies. A case of a 52‐year‐old female patient is reported and the published literature is reviewed.
Intravenously injected acetyltryptophan and acetylglycine are excreted in part by rats. Advantage was taken of this behavior to trap any radioactive acetylamino acids that are formed in vivo. The results show that natural amino acids can be acetylated in vivo.
The existence of an intimate relationship between the metabolism of calcium and magnesium in the animal body has long been postulated. In harmony with this hypothesis the writers have accumulated considerable evidence which points to a calcium involvement in the syndrome of magnesium deficiency. Certain aspects of such an involvement have already been pointed out by Kruse, Schmidt and McCollum and by Orent, Kruse and McCollum who observed that animals reared on a magnesium deficient diet showed a marked retention of calcium and an abnormally high percentage content of calcium in their bones. The phases of the involvement observed by the writers are that there is an accumulation of calcium in the viscera of the body, particularly in the kidneys, and that the magnesium level of the diet at which deficiency symptoms appear is controlled by the dietary level of calcium. A greater amount of magnesium is required to prevent the development of deficiency symptoms as the calcium of the diet is increased. This is illustrated by the performance of rats reared on diets containing the mineral composition given in Table I. The animals reared on the high calcium diet developed all the features common to magnesium deprivation such as hyperemia, hyperirritability, and cachexia. A large percentage of these animals died from convulsive seizures. Those that survived developed a greasy unkempt appearance, became emaciated, and in other ways showed signs of malnutrition. At the same magnesium level, the rats on the low calcium diet were maintained in a normal state of health and vigor. The females that were bred went through a successful gestation period and gave birth to young of normal weight. The accumulation of calcium in the viscera of the body of magnesium deficient rats is shown in Table II.
The diffusible substance present in blood acted as a thromboplastin in accelerating coagulation. The prolonged dialysis required to demonstrate this action produced destructive changes in the plasma factors involved in coagulation.
N-substituted amino acid can be separated by paper chromatographic method. Also, N-substitution leads to the extinction of fluorescence of amino acids.
The outstanding importance of the proteins in the structure of protoplasm, biocatalysis, reactions of immunity, and the control of heredity makes the quest for the understanding of the reactions required for the synthesis and the control of the synthesis of proteins of the greatest interest to biochemists.
Certain of the constituents of blood and spinal fluid in cases of epilepsy have been subjected to analysis by a number of investigators in order to test the hypothesis that the incidence of convulsions in this condition is associated with a disturbance of the ion balance of the body. No significant variation from normal has been found in the calcium content of the blood and spinal fluid in epileptics., , , Some time ago Hirschfelder and Haury reported that they observed low magnesium and high potassium levels in the blood plasma in a high percentage of epileptic subjects during convulsive attacks. To our knowledge virtually no information is available on the magnesium content of the spinal fluid and red blood corpuscles in epilepsy. Since the blood and spinal fluid of epileptic subjects were available to the authors, a series of analyses was undertaken on the composition of the blood and spinal fluid of subjects afflicted with epilepsy and convulsive conditions. The cerebrospinal fluid was collected in the course of encephalography. Determinations were made of the levels of plasma, red corpuscle and spinal fluid magnesium, serum and spinal fluid calcium, and spinal fluid inorganic phosphorus. Magnesium was determined by the method of Green-berg and Mackey, calcium by a modification of Kirk and Schmidt's procedure, and inorganic phosphorus according to Fiske and Subbarow's method. A statistical evaluation of the results is given in Table I. The convulsive states of the 28 subjects investigated may be classified on an etiological basis as follows: A comparison of the values of the arithmetical means with those for normal subjects taken from the compilation of Schmidt and Greenber is given in Table 11. The data show that the levels of the components analyzed are essentially normal with a tendency toward a greater degree of variation than is normally found in red corpuscle magnesium, serum calcium, and spinal fluid magnesium. Such variations from the normal arithmetical means as were found do not appear to be significant. The few instances of abnormally low or abnormally high analytical values that were observed did not fall into any special category of the cases.
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