Abdul Rehman Yousuf

University of Kashmir

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Sabzar Ahmad Dar

Zoological Survey of India

M. H. Balkhi

Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir

Farooz Ahmad Bhat

Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir

Arshid Jehangir

University of Kashmir

Praveen K. Mishra

University of Jammu

Farooq Ahmad Ganai

Sher-i-Kashmir Institute of Medical Sciences

Birgit Gaye

Universität Hamburg

Sushma Prasad

University of Potsdam

Ambili Anoop

Indian Institute of Science Education and Research Mohali

Mudasir A. Tantry

Cluster University Srinagar

Cooperative Institutions

University of Kashmir

Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir

Helmholtz Centre Potsdam - GFZ German Research Centre for Geosciences

University of Potsdam

Aquatic Systems (United States)

Veterinary & Animal Husbandry

Barkatullah University

Zoological Survey of India

Sher-i-Kashmir Institute of Medical Sciences

Indian Institute of Technology Roorkee

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Testing the validity of productivity proxy indicators in high altitude Tso Moriri Lake, NW Himalaya (India)

Palaeogeography Palaeoclimatology Palaeoecology (2016)

Sushma Prasad Praveen K. Mishra Philip Menzel Birgit Gaye Arshid Jehangir

Isotopic signature

Biogenic silica

10.1016/j.palaeo.2016.02.027

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Citations (15)

Oxidative stress in the freshwater cyprinid crucian carp (Carassius carassiusL.) upon chronic exposure to endosulfan

Toxicological & Environmental Chemistry Reviews (2014)

Sabzar Ahmad Dar Abdul Rehman Yousuf M. H. Balkhi Md. Niamat Ali

Oxidative stress and antioxidant responses of crucian carp, upon chronic exposure to endosulfan, were evaluated in vivo. The lethal concentration (LC50–96 h) was 70 μg L−1; on its basis, the fish were exposed to endosulfan at 20, 35, and 50 μg L−1 and autopsy was done on days 1, 2, 3, 4, 7, 14, 21, 28, and 35. Lipid peroxidation was induced in a concentration-dependent manner, being highest at 50 μg L−1 (3/4 LC50–96 h, sub-lethal concentration-I, SL-I) on day 4 (720% versus control), followed in its extent (490%) at 30 μg L−1 (1/2 LC50–96 h, sub-lethal concentration-II, SL-II) on day 7 and lowest (260%) at 10 μg L−1 (1/4 LC50–96 h, sub-lethal concentration-III, SL-III) on day 14. Glutathione showed a concentration- and time-dependent elevation in the initial phase, with highest level on day 4 (180%) at SL-I, but showed significant reduction in all test concentrations from day 21 of post-exposure. Superoxide dismutase was decreased significantly throughout the study, with highest reduction (63%) on day 4 at SL-I; catalase increased in all test concentrations up to day 14 but showed a significant decrease from the day 28 of post-exposure. The potential role of these parameters as indicators of pesticide pollution in aquatic systems is discussed.

Crucian carp

Endosulfan

10.1080/02772248.2014.982122

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Citations (10)

Podophyllum hexandrum ameliorates endosulfan-induced genotoxicity and mutagenicity in freshwater cyprinid fish crucian carp

Figshare (2021)

Sabzar Ahmad Dar Abdul Rehman Yousuf M. H. Balkhi Bashir Ahmad Ganai Mudasir A. Tantry

Context: Medicinal plants continue to act as a repository for novel drug leads with novel mechanisms of action. Podophyllum hexandrum Royale (Berberideceae) treats diverse conditions in folk medicine. Objective: The antimutagenic potential of P. hexandrum was evaluated against endosulfan-induced clastogenicity in a piscine model by cytogenetic endpoints. Materials and methods:Podophyllum hexandrum rhizomes were subjected to successive solvent extraction. Fish were exposed to hexane, chloroform, ethyl acetate, methanol and aqueous extracts (15 mg/L each) of plant and endosulfan (0.05 mg/L) alone followed by their combination for antimutagenicity estimates. Chromosomal aberrations (CA) were made from kidney cells and micronuclei (MN) slides from peripheral blood erythrocytes at 48, 72 and 96 h. Antioxidant activity was analyzed by the DPPH assay. Phytochemical analyses were carried out using chromatographic and spectroscopic techniques. Results: Endosulfan induced significant (p R²=.900) with antimutagenic activity, whereas EE-F4 seemed to act through a different mechanism. Discussion and conclusion: This study confirms the antimutagenic potential of the subject plant with the identification of some novel compounds, justifying their use in folk medicine, and their corresponding benefit to mankind.

Crucian carp

Podophyllum

Endosulfan

Grass carp

10.6084/m9.figshare.4001457

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Citations (0)

Massive land system changes impact water quality of the Jhelum River in Kashmir Himalaya

Environmental Monitoring and Assessment (2016)

Mohmmad Irshad Rather Irfan Rashid Nuzhat Shahi Khalid Omar Murtaza Khalida Hassan

10.1007/s10661-016-5190-x

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Citations (81)

Pharmacological and toxicological evaluation ofUrtica dioica

Pharmaceutical Biology (2012)

Sabzar Ahmad Dar Farooq Ahmad Ganai Abdul Rehman Yousuf M. H. Balkhi Towseef Mohsin Bhat

Context: Medicinal plants are a largely unexplored source of drug repository. Urtica dioica L. (Urticaceae) is used in traditional medicine to treat diverse conditions.Objective: The present study describes the antidiabetic, antiinflammatory, antibacterial activity, and toxicological studies of Urtica dioica.Materials and methods: U. dioica leaves were subjected to solvent extraction with hexane, chloroform, ethyl acetate, methanol, and aqueous, respectively, and screened for antidiabetic (300 mg/kg bw by glucose tolerance test; GTT), antiinflammatory (200 mg/kg bw by rat paw edema assay) and antibacterial activities [by disc-diffusion and minimum inhibitory concentration (MIC) assays]. Toxicological studies were carried on Artemia salina and Wistar rats; phytochemical analyses were carried out, using chromatographic and spectroscopic techniques.Results: The aqueous extract of U. dioica (AEUD) significantly (p < 0.001; 67.92%) reduced the blood glucose level during GTT in Wistar rats with an effective dose of 300 mg/kg bw in dose-dependent studies. High-performance liquid chromatography with photodiode-array detection (HPLC-DAD) analysis showed the presence of hydroxycinnamic acid derivatives and flavonoids in AEUD. Hexane Fraction-2 (HF2) exhibited both antiinflammatory activity (48.83% after 3 h), comparable to that of indomethacin (53.48%), and potent antibacterial activity with MIC values ranging from 31.25–250 µg/mL against all the tested strains. Gas chromatography–mass spectrometry (GC–MS) analysis showed fatty acid esters and terpenes as the major constituents of HF2. Toxicity tests showed higher safety margin of all the solvent extracts with LC50 > 1000 μg/mL each on A. salina.Discussion and conclusion: Our results showed that the U. dioica leaves are an interesting source of bioactive compounds, justifying their use in folk medicine, to treat various diseases.

Urtica dioica

Phytochemical

Artemia salina

10.3109/13880209.2012.715172

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Citations (81)

Investigating the role of meltwater versus precipitation seasonality in abrupt lake-level rise in the high-altitude Tso Moriri Lake (India)

Palaeogeography Palaeoclimatology Palaeoecology (2018)

Praveen K. Mishra Sushma Prasad Arshid Jehangir Ambili Anoop Abdul Rehman Yousuf

Meltwater

Westerlies

Varve

Snowmelt

10.1016/j.palaeo.2017.12.026

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Citations (15)

An introduction about Genotoxicology Methods as Tools for Monitoring Aquatic Ecosystem: Present status and Future perspectives

Fisheries and Aquaculture Journal (2016)

Sabzar Ahmad Dar Abdul Rehman Yousuf M. H. Balkhi

10.4172/2150-3508.1000158

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Citations (15)

Podophyllum hexandrum ameliorates endosulfan-induced genotoxicity and mutagenicity in freshwater cyprinid fish crucian carp

Pharmaceutical Biology (2016)

Sabzar Ahmad Dar Abdul Rehman Yousuf M. H. Balkhi Bashir Ahmad Ganai Mudasir A. Tantry

Context: Medicinal plants continue to act as a repository for novel drug leads with novel mechanisms of action. Podophyllum hexandrum Royale (Berberideceae) treats diverse conditions in folk medicine.Objective: The antimutagenic potential of P. hexandrum was evaluated against endosulfan-induced clastogenicity in a piscine model by cytogenetic endpoints.Materials and methods: Podophyllum hexandrum rhizomes were subjected to successive solvent extraction. Fish were exposed to hexane, chloroform, ethyl acetate, methanol and aqueous extracts (15 mg/L each) of plant and endosulfan (0.05 mg/L) alone followed by their combination for antimutagenicity estimates. Chromosomal aberrations (CA) were made from kidney cells and micronuclei (MN) slides from peripheral blood erythrocytes at 48, 72 and 96 h. Antioxidant activity was analyzed by the DPPH assay. Phytochemical analyses were carried out using chromatographic and spectroscopic techniques.Results: Endosulfan induced significant (p < .05) MN, authenticated by scanning electron microscopy, and CA in a time-dependent manner. However, methanol and ethyl acetate extracts revealed ameliorating effects. The column eluted methanolic fraction-2 (ME-F2) showed highest reduction profile of 83 and 84% in CA and MN, followed in its extent (73 and 72%) by ethyl acetate fraction-4 (EE-F4). ME-F2 and EE-F4 showed three and six major peaks when analyzed by GC-MS. To explore possible mechanism of action, ME-F2 showed potent antioxidant potential and strong correlation (R2 = .900) with antimutagenic activity, whereas EE-F4 seemed to act through a different mechanism.Discussion and conclusion: This study confirms the antimutagenic potential of the subject plant with the identification of some novel compounds, justifying their use in folk medicine, and their corresponding benefit to mankind.

Podophyllum

10.1080/13880209.2016.1233568

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Citations (2)

Testing and refinement of elemental proxies in tropical lakes from the Indian subcontinent

Earth Surface Processes and Landforms (2024)

Praveen K. Mishra Arshid Jehangir Abdul Rehman Yousuf Sushma Prasad Ambili Anoop

Abstract The conventional approach of using modern values of lake hydrochemistry and sediment composition as key parameters for identifying proxies for environmental reconstruction is complicated by regional climate, catchment geology, lake morphometry and anthropogenic input. In contrast to modern studies from lakes in the north‐temperate regions, reliable proxy indicators for past environmental change from tropical lake systems are still lacking. In this study, we compare new surface geochemical and mineralogical data from the Manasbal Lake, Kashmir (India), with other lakes situated in climatically and geomorphologically distinct regimes with varying degrees of pollution (Tso Moriri in north‐western Himalaya and Lonar in central India). We characterise external (e.g., geology and weathering), internal (e.g., lake water mixing and evaporation) factors and human activities influencing sediment composition and spatial distribution of proxies in each of these lakes to evaluate the usefulness of some of the commonly used proxies, as well as ascertain conditions where they might be applicable. Our results show that (i) morphometric parameters (such as lake size, water depth and catchment vs. lake area) variably influence the spatial distribution of sediments and proxies on the lake bottom highlighting the limitations of using single cores for long‐term palaeoclimate reconstruction; (ii) hydrochemical proxies (such as Na + /Na + +Ca 2+ and Mg/Ca) can delineate endogenic (Lonar and Tso Moriri lakes) versus allogenic (Manasbal Lake) influence on modern sediment characteristics; (iii) the compilation of heavy metal data (e.g., Fe, Zn, Mn, Cr and Ni) from all three lake basins with varying degrees of pollution highlights the limitations of using them to characterise weathering conditions in these basins; and (iv) human impact must be precluded before using the most promising endogenic minerals (calcite, aragonite, gypsum and pyrite) as palaeoenvironmental/palaeoclimate indicators.

Indian subcontinent

10.1002/esp.5787

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Assessment of endosulfan induced genotoxicity and mutagenicity manifested by oxidative stress pathways in freshwater cyprinid fish crucian carp (Carassius carassius L.)

Chemosphere (2014)

Sabzar Ahmad Dar Abdul Rehman Yousuf M. H. Balkhi Farooq Ahmad Ganai Farooz Ahmad Bhat

Endosulfan

Crucian carp

10.1016/j.chemosphere.2014.07.031

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Citations (49)