W B Malarkey

The Ohio State University

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Janice K. Kiecolt‐Glaser

Institute for Behavioral Medicine

Ronald Glaser

The Ohio State University

John T. Cacioppo

The University of Texas at Arlington

John F. Sheridan

Institute for Behavioral Medicine

Robert C. MacCallum

University of North Carolina at Chapel Hill

Ronald Glaser

The Ohio State University

Gerlinda E. Hermann

Klinik und Poliklinik für Neurologie

Jeffrey R. Stowell

Eastern Illinois University

Catherine M. Alfano

Feinstein Institute for Medical Research

Tamara L. Newton

University of Louisville

Cooperative Institutions

The Ohio State University

Institute for Behavioral Medicine

The Ohio State University Wexner Medical Center

Harvard University

Purdue University West Lafayette

Northwestern University

University of Michigan–Ann Arbor

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Bridge University

University of Washington

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Patients with primary hypothyroidism presnting as prolactinomas

The American Journal of Medicine (1987)

Mark R. Grubb Donald W. Chakeres W B Malarkey

Galactorrhea

Prolactinoma

Pituitary Tumors

Thyrotropic cell

Prolactin cell

10.1016/0002-9343(87)90911-9

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Citations (54)

Hostile behavior during marital conflict alters pituitary and adrenal hormones.

Psychosomatic Medicine (1994)

W B Malarkey Janice K. Kiecolt‐Glaser Dennis K. Pearl Ronald Glaser

We evaluated hormonal changes and problem-solving behaviors in 90 newlywed couples who were admitted to a hospital research unit for 24 hours. The subjects were selected on the basis of stringent mental and physical health criteria, and admissions were scheduled during the follicular phase of the woman's menstrual cycle. For frequent, unobtrusive endocrine sampling during the interaction tasks, a long polyethylene tube was attached to a heparin well, allowing nurses to draw blood samples at set intervals, out of subjects' sight. Five blood samples were obtained before, during, and after a 30-minute structured problem-solving or conflict task. The conflict session was recorded on videotapes that were later scored for problem-solving behaviors using the Marital Interaction Coding System (MICS). Marital conflict and MICS-coded hostile or negative behavior during conflict was closely linked to changes in serum hormonal levels across five of the six hormones we studied, in spite of the high marital satisfaction of our newlywed couples and the healthy lifestyles demanded by our exclusion criteria. Hostile behavior was associated with decreased levels of prolactin (PRL) and increases in epinephrine (EPI), norepinephrine (NEPI), ACTH, and growth hormone (GH), but not cortisol. These data suggest that the endocrine system may be an important mediator between personal relationships and health.

10.1097/00006842-199401000-00006

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Citations (207)

Marital behavior, oxytocin, and wound healing

Brain Behavior and Immunity (2010)

Jean‐Philippe Gouin S. Carter Hossein Pournajafi‐Nazarloo Ronald Glaser W B Malarkey

Stroke

Preparedness

Family Caregivers

10.1016/j.bbi.2010.07.026

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Citations (12)

Mechanisms of action of long-acting analogs of somatostatin

Regulatory Peptides (1993)

Feng Chen M. Sue O’Dorisio Gerlinda E. Hermann John R. Hayes W B Malarkey

Mechanism of Action

Pentapeptide repeat

10.1016/0167-0115(93)90138-x

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Citations (20)

Delayed diagnosis of psychological erectile dysfunction because of the presence of macroprolactinemia.

The Journal of Clinical Endocrinology & Metabolism (1996)

Alexandre Guay P Sabharwal S. K. Varma W B Malarkey

Idiopathic hyperprolactinemia can be found in men with either normal or low serum testosterone (T) levels. The explanation for the differing effects on T of similar PRL levels has not been found. Macroprolactinemia, as a clinical entity, has been reported mostly in women. These macromolecules are biologically less active and/or are transported less easily across the capillary bed than the 22-kDa molecules. Therefore, women with elevated PRL levels retain normal menses and fertility. We studied six men, aged 28-53 yr (mean, 45 yr), in whom hyperprolactinemia was initially considered to be the cause of their erectile dysfunction. PRL levels ranged from 25-92 ng/mL (normal, 2-15 ng/mL), but T and gonadotropin levels were normal, suggesting that PRL was not disrupting gonadotropin and gonadal steroid function. The results of magnetic resonance imaging studies of the pituitary gland were normal. Separation by Sephadex G-100 column chromatography showed a predominance (85-90%) of big (60 kDa) and big big ( > 150 kDa) PRL, in contrast to the predominance of 22-kDa PRL in normal subjects. Nocturnal tumescence testing was normal, supporting the diagnosis of psychogenic impotence in these subjects, and potency returned after counseling. Hence, the biologically inactive macroprolactinemia did not cause any organic derangement in erectile function. It further obscured and delayed the appropriate diagnosis and treatment of these individuals.

Nocturnal penile tumescence

Gonadotropin

Psychogenic disease

10.1210/jcem.81.7.8675569

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Citations (61)

Behavior: The Endocrine-Immune Interface and Health Outcomes

KARGER eBooks (2001)

W B Malarkey R. Glaser Janice K. Kiecolt‐Glaser P.T. Marucha

Interface (matter)

10.1159/000059279

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Serum Levels of Prolactin, Growth Hormone, and Cortisol in Burn Patients: Correlations with Severity of Burn, Serum Cytokine Levels, and Fatality

Journal of Burn Care & Rehabilitation (2004)

Amy L. Dugan W B Malarkey Sandy Schwemberger Edward C. Jauch Cora K. Ogle

In this study, we measured serum prolactin (PRL), cortisol, growth hormone, interleukin (IL)-1beta, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor-alpha in patients admitted with small-to-moderate burn injuries. Serum samples were obtained at the time of admission from 49 adult male burn patients with ages ranging from 18 to 91 years and TBSA ranging from 0.001 to 60%. The levels of serum PRL, IL-8, IL-6, and IL-1beta correlated positively with the TBSA, whereas only serum IL-8 levels correlated positively with fatality. Each of these factors were increased at least 2-fold at the higher burn severity. Not surprisingly, there was a large degree of variability in the hormone and cytokine levels in this patient population, which presumably reflects individual levels of stress, as well as other physiological variables. We also studied relationships between serum hormone levels and serum cytokine levels in this context. Linear regression analysis revealed a significant positive correlation between the serum PRL level and the levels of IL-10, IL-6, and IL-8. These results indicate that PRL responds to burn injury at early time points and that a subset of cytokines are involved in the early response to burn injury.

10.1097/01.bcr.0000124785.32516.cb

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Citations (25)

Localization of growth hormone messenger ribonucleic acid in the human immune system--a Clinical Research Center study.

The Journal of Clinical Endocrinology & Metabolism (1996)

Hong Wu Rathinasamy Sheela Devi W B Malarkey

GH is an immunomodulatory factor that can be synthesized and secreted by mononuclear leukocytes. To determine if GH can be produced by the human immune system, we assessed the presence of GH messenger RNA (mRNA) in both normal and abnormal human lymphoid tissues by RT-PCR and nonisotopic in situ mRNA hybridization. The predicted PCR product of 16lbp from human thymus, spleen, tonsil, lymph node, thymoma, and T and B cell lymphomas was similar to the product amplified from the human pituitary. Restriction enzyme digestion confirmed that complementary DNA generated using GH primers originated from GH mRNA. Furthermore, we performed in situ hybridization to localize the GH mRNA-positive cells. A hybridization signal for GH mRNA was found in all tissues examined. The distribution patterns of GH in normal lymphoid tissues suggested that GH can be produced by lymphocytes, as well as endothelial cells and other cell types. Also, GH mRNA-positive cells were distributed diffusely throughout T and B cell lymphomas and a thymoma. Our results demonstrate GH gene expression in normal and neoplastic human lymphoid tissues including nonlymphoid cells. This finding supports the hypothesis that the human immune system is an extrapituitary site of GH gene expression that may serve as an autocrine/paracrine factor in immunomodulation.

10.1210/jcem.81.3.8772612

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Citations (64)

Plasma cortisol levels and reactivation of latent Epstein-Barr virus in response to examination stress

Psychoneuroendocrinology (1994)

Ronald Glaser Dennis K. Pearl Janice K. Kiecolt-Glaser W B Malarkey

10.1016/0306-4530(94)90023-x

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Citations (155)

Hyperthyroidism, Hyperprolactinemia, and Macroprolactinemia

Annals of Internal Medicine (1990)

Jacobo Wortsman W B Malarkey

Letters and Corrections15 February 1990Hyperthyroidism, Hyperprolactinemia, and MacroprolactinemiaJacobo Wortsman, MD, William B. Malarkey, MDJacobo Wortsman, MDSearch for more papers by this author, William B. Malarkey, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-4-309_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:We read with interest the excellent review on thyrotropin-secreting pituitary adenomas by Gesundheit and colleagues (1). Elevated serum prolactin levels were found in seven of their nine patients. Although the presence of hyperprolactinemia in the setting of hyperthyroidism is unusual, the abnormality is not confined solely to thyrotropin-secreting tumors. In several patients, hyperthyroidism has also been associated with macroprolactinemia, a nontumoral entity characterized by high circulating levels of prolactin molecules of very large molecular weight (macroprolactin) (2). Abnormally elevated concentrations of macroprolactin have been found in both men and women (3) and do not usually interfere with...References1. GesundheitPetrickNissim NPM. Thyrotropin-secreting pituitary adenomas: clinical and biochemical heterogeneity-case reports and follow up of nine patients. Ann Intern Med. 1989;111:827-35. LinkGoogle Scholar2. JacksonWortsmanMalarkey RJW. Characterization of a large molecular weight prolactin in women with idiopathic hyperprolactinemia and normal menses. J Clin Endocrinol Metab. 1985;61:258-64. CrossrefMedlineGoogle Scholar3. WortsmanCarlsonMalarkey JHW. Macroprolactinemia as the cause of elevated serum prolactin in men. Am J Med. 1989;86:704-6. CrossrefMedlineGoogle Scholar4. JacksonWortsmanMalarkey RJW. Persistence of large molecular weight prolactin secretion during pregnancy in women with macroprolactinemia and its presence in fetal cord blood. J Clin Endocrinol Metab. 1989;68:1046-50. CrossrefMedlineGoogle Scholar5. MalarkeyJacksonWortsman WRJ. Long term assessment of patients with macroprolactinemia. Fertil Steril. 1988;50:413-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1990Volume 112, Issue 4Page: 309-309KeywordsAttentionHyperthyroidismPituitary tumorsProlactin Issue Published: 15 February 1990 PDF downloadLoading ...

Galactorrhea

10.7326/0003-4819-112-4-309_1

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