Yuanhui Zhao

Nanjing University

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Limin Su

Northeast Normal University

Chao Li

China Three Gorges University

Christopher J. Martyniuk

University of Florida

Weichao Qin

Taiyuan University of Technology

Jia He

Beijing Normal University

Yang Wen

Peking University

Liansheng Wang

Hubei Engineering University

Lingyun Fan

Henan University of Science and Technology

Yanan Zhang

Jilin University

Yu Huang

Chongqing Three Gorges University

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Northeast Normal University

Chinese Academy of Sciences

Nanjing University

Ocean University of China

Ministry of Natural Resources

Nanjing Medical University

University of Chinese Academy of Sciences

Sun Yat-sen University

China Pharmaceutical University

Huazhong University of Science and Technology

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Metabolomics Investigation on the Volatile and Non-Volatile Composition in Enzymatic Hydrolysates of Pacific Oyster (Crassostrea Gigas)

Li Liu Yuanhui Zhao Shixue Lu Yihuan Liu Mingyong Zeng

To investigate the differences of volatile and non-volatile metabolites between oyster enzymatic hydrolysates and boiling concentrates, molecular sensory analysis and untargeted metabolomics were employed. “Grassy,” “fruity,” “oily/fatty,” “fishy,” and “metallic” were identified as sensory attributes used to evaluate different processed oyster homogenates. Sixty-nine and 42 volatiles were identified by gas chromatography–ion mobility spectrometry and gas chromatography–mass spectrometry, respectively. Pentanal, 1-penten-3-ol, hexanal, (E) -2-pentenal, heptanal, (E) -2-hexenal, 4-octanone, (E)-4-heptenal, 3-octanone, octanal, nonanal, 1-octen-3-ol, benzaldehyde, (E)-2-nonenal, and (E, Z)-2,6-nonadienal were detected as the key odorants (OAV>1) after enzymatic hydrolysis. Hexanal, (E)-4-heptenal, and (E) -2-pentenal were significantly associated with off-odor, and 177 differential metabolites were classified. Aspartate, glutamine, alanine, and arginine were the key precursors affecting the flavor profile. Linking sensory descriptors to volatile and nonvolatile components of different processed oyster homogenates will provide information for the process and quality improvement of oyster products.

Pacific oyster

10.2139/ssrn.4266968

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Citations (2)

In vivo and in silico toxicity assessment of four common liquid crystal monomers to Daphnia magna: Novel endocrine disrupting chemicals in crustaceans?

The Science of The Total Environment (2023)

Yang Zi Jia He Fengchang Wu Yuanhui Zhao Xiaowei Jin

Daphnia magna

10.1016/j.scitotenv.2023.168757

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Citations (10)

Axl Mediates Resistance to Respiratory Syncytial Virus Infection Independent of Cell Attachment

American Journal of Respiratory Cell and Molecular Biology (2022)

Dan Zhang Yuanhui Zhao Lingling Wang Xiaoxin You Jingjing Li

Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections in infants and young children. Axl, a TAM family receptor tyrosine kinase, has been demonstrated to be a receptor mediating enveloped virus infection. Here we show that Axl functions as a suppressor of antiviral response during RSV infection. Knockdown of Axl expression in human cells resulted in cell resistance to RSV infection, although the treatment did not significantly affect RSV binding or cell entry. Mice deficient in Axl showed resistance to RSV infection, including reduction in viral load and in pulmonary injury. Although T lymphocyte and macrophage infiltration was reduced, more IFN-γ-producing cells were present in BAL fluid in Axl-/- mice. Fewer alternatively activated alveolar macrophages were found in the lungs of Axl-/- mice. Axl-/- mouse embryonic fibroblasts and siRNA-treated human cells had more robust IFN-β and IFN-stimulated gene induction of antiviral genes. Furthermore, reexpression of Axl using adenovirus-mediated Axl delivery repressed IFN-stimulated gene induction in Axl-null mouse embryonic fibroblasts by RSV infection. The results suggest that Axl, independent of being a virus entry receptor of RSV infection, negatively regulates IFN signaling to modulate host antiviral response against RSV infection.

10.1165/rcmb.2021-0362oc

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Citations (10)

Optimization of Sturgeon Cartilage Products and Its Regulation on Human Chondrocyte Inflammation

DOAJ (DOAJ: Directory of Open Access Journals) (2022)

Hengge LIU Xinxing Xu Fan Bai Jinlin WANG Ruichang Gao

10.13386/j.issn1002-0306.2021100051

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Predicting toxicities of substituted aromatic hydrocarbons to fish by toxicities toDaphnia MagnaorPhotobacterium Phosphoreum¹

Toxicological & Environmental Chemistry Reviews (1995)

Yuanhui Zhao Yibing He Liansheng Wang

Relationships between toxicities of substituted aromatic hydrocarbons to Daphnia magna and to Fathead minnows or Photobacterium phosphoreum were studied based on structure‐activity equations we established. Good relationships between toxicities of chemicals to Daphnia magna and to Fathead minnows, Photobacterium phosphoreum were found for a wide range of chemicals. The toxicity data of fish can be predicted by the toxicity data of Daphnia magna or Photobacterium phosphoreum. It is probable that the toxicities of chemicals to the three organisms are similar.

Photobacterium phosphoreum

Daphnia magna

Photobacterium

Ecotoxicity

10.1080/02772249509358237

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Citations (13)

Evaluation of the partitioning of hydrophobic pollutants between aquatic and solid phases in natural systems

The Science of The Total Environment (1996)

Yuanhui Zhao Pei-Zhen Lang

Aqueous two-phase system

10.1016/0048-9697(95)04853-7