Howard Kessler

University of Pennsylvania

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William H. Hartz

Pennsylvania Hospital

Robert A. Gatenby

Moffitt Cancer Center

Lawrence J. Solin

Einstein Medical Center Philadelphia

Delray J. Schultz

Millersville University

Edward U. Balsbaugh

North Dakota Agricultural Experiment Station

Nicholas A. Hanchak

University of Pennsylvania

Lawrence R. Coia

Community Medical Center

Murray K. Dalinka

University of Pennsylvania

George Broder

University of Arizona

Barbara Fowble

University of California, San Francisco

Cooperative Institutions

Fox Chase Cancer Center

University of Pennsylvania

Temple University

Hospital of the University of Pennsylvania

Duke Medical Center

Thomas Jefferson University

Jeanes Hospital

Johns Hopkins University

Duke University Hospital

New York University

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Postmenopausal Hormone Replacement Therapy: Effect on Diagnosis and Outcome in Early-Stage Invasive Breast Cancer Treated With Conservative Surgery and Radiation

Journal of Clinical Oncology (1999)

Barbara Fowble Alexandra L. Hanlon Gary M. Freedman A. Patchefsky Howard Kessler

PURPOSE: To compare the pretreatment characteristics and outcome of postmenopausal women with stage I-II breast cancer treated with conservative surgery and radiation who had a history of hormone replacement therapy (HRT) with those who had never received HRT. MATERIALS AND METHODS: From 1979 to 1993, 485 postmenopausal women underwent excisional biopsy, axillary dissection, and radiation for stage I-II breast cancer. The median follow-up was 5.9 years. One hundred forty-one patients reported a history of HRT. The median length of use was 5 years. Three hundred forty-four patients reported no history of HRT. RESULTS: Statistically significant differences between the two groups were observed for median age (HRT 60 years v no HRT 64 years; P = .0009), median weight (HRT 142 lbs v no HRT 152 lbs; P = .004), clinical tumor size ≤ 2 cm (HRT 77% v no HRT 66%; P = .02), and the use of re-excision (HRT 62% v no HRT 49%; P = .01). The method of detection by mammogram only (HRT 52% v no HRT 42%; P = .06) was of borderline statistical significance. The HRT patients had a statistically significant increased cumulative incidence of ipsilateral breast tumor recurrence (8% v 2%; P = .02), a statistically significant decreased cumulative incidence of distant metastases (HRT 6% v no HRT 17%; P = .01), and a borderline statistically significant improvement in cause-specific survival at 10 years (HRT 92% v no HRT 86%; P = .07). Postmenopausal women with a history of HRT did not have an increased risk of contralateral breast cancer or second non–breast cancer malignancy. CONCLUSION: This study failed to identify an adverse effect of HRT on breast cancer mortality in patients with stage I-II disease treated with conservative surgery and radiation.

Conservative Treatment

Hormone Therapy

10.1200/jco.1999.17.6.1680

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Citations (47)

Percutaneous Catheter Drainage for Malignant Pericardial Effusion

Journal of Vascular and Interventional Radiology (1991)

Robert A. Gatenby William H. Hartz Howard Kessler

10.1016/s1051-0443(91)72490-1

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Citations (19)

Succession of Adult Coleoptera in Bovine Manure in East Central South Dakota1

Annals of the Entomological Society of America (1972)

Howard Kessler Edward U. Balsbaugh

Journal Article Succession of Adult Coleoptera in Bovine Manure in East Central South Dakota Get access Howard Kessler, Howard Kessler 2 Entomology-Zoology Department, South Dakota State University, Brookings 57006. 2Present address: Pesticide Project Officer, 315 State Office Building, Alabama State Department of Public Health, Montgomery 36104. Search for other works by this author on: Oxford Academic Google Scholar Edward U. Balsbaugh, Jr Edward U. Balsbaugh, Jr Entomology-Zoology Department, South Dakota State University, Brookings 57006. Search for other works by this author on: Oxford Academic Google Scholar Annals of the Entomological Society of America, Volume 65, Issue 6, 15 November 1972, Pages 1333–1336, https://doi.org/10.1093/aesa/65.6.1333 Published: 15 November 1972 Article history Received: 21 March 1972 Published: 15 November 1972

Hydrophilidae

10.1093/aesa/65.6.1333

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Citations (26)

Further Tests of Aerial Applications of ULV Organic Phosphate Insecticides for Controlling the Horn Fly in South Dakota12

Journal of Economic Entomology (1970)

Edward U. Balsbaugh Howard Kessler

During the summer of 1969, Ravap® (a 1:4 mixture of dichlorvos and Cardona® (2-chloro-1-(2,4,5-trichlorophenyl) vinyl dimethyl phosphate)) and dichlorvos were tested in ULV formulations and applied by aircraft to control Haematobia irritans (L.) on range cattle in South Dakota. Ravap, in 4 pounds per gallon oil solution, was applied at 12 ounces per acre and dichlorvos at 90% solution at 2½ ounces per acre. Counts made the day following application showed that Ravap gave 78.2% reduction in the average number of horn flies per side on cows and 82.4% reduction on calves. Dichlorvos on the day following application gave 53.7% reduction on cows and 67.8% reduction on calves. Neither compound showed economic control at the end of 1 week. Horn flies, as counted in the check herd, showed 2 seasonal peaks, the average on July 15 was 1000 per side and on August 25 was 440 per side. The mid-season low average of 78 per side occurred August 4.

Dichlorvos

Haematobia irritans

Aerial application

10.1093/jee/63.6.1915

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Scenario development, qualitative causal analysis and system dynamics

Revista de Matemática Teoría y Aplicaciones (1998)

Michael H. Ruge Howard Kessler Ajit Singh Shahram Hejazi

The aim of this article is to demonstrate that technology assessments can be supported by methods such as scenario modeling and qualitative causal analysis. At Siemens, these techniques are used to develop preliminary purely qualitative models. These or parts of these comprehensive models may be extended to system dynamics models.While it is currently not possible to automatically generate a system dynamics models (or vice versa, obtain a qualitative simulation model from a system dynamics model), the two thechniques scenario development and qualitative causal analysis provide valuable indications on how to proceed towards a system dynamics model. For the qualitative analysis phase, the Siemens – proprietary prototype Computer – Aided Technology Assessment Software (CATS) supportes complete cycle and submodel analysis.

Qualitative analysis

Siemens

Dynamics

Causal loop diagram

Causal model

10.15517/rmta.v5i1.153

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Citations (2)

Multistrategy health education program to increase mammography use among women ages 65 and older.

PubMed (1992)

Barbara K. Rimer Nancy Resch Eunice S. King Eric A. Ross Caryn Lerman

Mammography use decreases with age although the risk of breast cancer increases with age. Medicare now provides biennial coverage for screening mammography. This study was designed to simulate the Medicare condition by subsidizing mammography among women in eight retirement communities in the metropolitan Philadelphia area. The study also measured the impact of health education interventions and the presence of a mobile mammography van on increased use of mammography. Retirement communities were assigned randomly to the control (cost subsidy alone) or experimental group (cost subsidy, mammography van, and tailored health education interventions). A total of 412 women ages 65 and older who had not had mammograms in the previous year were surveyed at baseline and 3 months later. Analytic techniques reflected the cluster nature of the randomization. Women in the experimental group were significantly more likely than the control group women to have obtained mammograms. Forty-five percent of the experimental group women compared with 12 percent of the control group women subsequently had mammograms in the 3 months after the baseline interview (P less than .001). Logistic regression analysis for mammography use indicated an odds ratio of 6.1 associated with being in the experimental group. For women in the experimental group, a separate logistic regression for mammography use showed an odds ratio of 7.8 associated with attendance at the educational presentation. The results suggest that Medicare coverage alone will not increase mammography use sufficiently to achieve year 2000 objectives. However, the addition of access enhancing and health education interventions boosts utilization dramatically.

Attendance

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Citations (106)

An Ecological Study of Coleoptera Succession in Bovine Manure with Emphasis on Natural Enemies of the Face Fly (Musca autumnalis De Geer) in Eastcentral South Dakota

Howard Kessler

Source

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Interaction of monocytes with tumor cells coated with complement with or without antibody

Cellular Immunology (1980)

Howard Kessler Albert F. LoBuglio

Raji cell

Immune adherence

10.1016/0008-8749(80)90036-2

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Citations (6)

Downstaging of Breast Carcinomas in Older Women Associated with Mammographic Screening

The Breast Journal (1999)

Lawrence J. Solin Delray J. Schultz Howard Kessler Nicholas A. Hanchak

The efficacy of mammographic screening for older women has not been well studied. The present study was designed to evaluate for downstaging of breast carcinomas associated with mammographic screening in older women. The study population consisted of 130 women age >/=65 years with newly diagnosed breast carcinoma in 1993-1994 and was obtained from women enrolled in a large health maintenance organization. Mammographic screening, if done, was performed by a network of predominantly community-based radiologists. Significant downstaging was found for the breast cancers detected in women who had undergone mammographic screening compared to the breast cancers detected in women who had not undergone mammographic screening. The American Joint Committee on Cancer (AJCC) clinical stage was stage 0 and stage I in 7% (8/107) and 73% (78/107), respectively, of the breast cancers detected in women who had undergone mammographic screening compared to 0% (0/23) and 22% (5/23), respectively, of the breast cancers detected in women who had not undergone mammographic screening (p < 0.0001). Clinical Tis and T1 tumors were found in 7% (8/107) and 74% (79/107), respectively, of the breast cancers detected in women who had undergone mammographic screening compared to 0% (0/23) and 22% (5/23), respectively, of the breast cancers detected in women who had not undergone mammographic screening (p < 0.0001). Of the 102 AJCC clinical stage I-II breast cancers with known pathologic axillary lymph node staging, lymph node stage was N0 for 76% (66/87) of the women who had undergone mammographic screening compared to 53% (8/15) of the women who had not undergone mammographic screening (p = 0.019). The results of downstaging reported in this study are important because earlier staged lesions are associated with an improved prognosis and an increased potential for breast-conservation treatment. These findings have shown that mammographic screening is effective in downstaging breast carcinomas found in older women.

Breast Cancer Screening

Breast carcinoma

10.1046/j.1524-4741.1999.00131.x

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Citations (9)

Hoarseness; A unique clinical presentation for renal cell carcinoma

Urology (1992)

Richard E. Greenberg Jeffrey T. Cooper Robert L. Krigel Rolf Richter Howard Kessler

Presentation (obstetrics)

10.1016/0090-4295(92)90518-2

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Citations (26)