Jaime Bermejo

Instituto de Productos Naturales y Agrobiología

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Francisco Estévez

Universidad de Las Palmas de Gran Canaria

Francisco León

University of Florida

Ignacio Brouard

Consejo Superior de Investigaciones Científicas

José Quintana

University of Puerto Rico System

Antonio González

Instituto de Investigación Sanitaria de Santiago

Fadila Benayache

Constantine 1 University

Jorge Triana

Universidad de Las Palmas de Gran Canaria

Samir Benayache

Constantine 1 University

Juan I. Padrón

Instituto de Productos Naturales y Agrobiología

Guillermo M. Massanet

Universidad de Cádiz

Cooperative Institutions

Universidad de La Laguna

Instituto de Productos Naturales y Agrobiología

Universidad de Las Palmas de Gran Canaria

Constantine 1 University

Consejo Superior de Investigaciones Científicas

Canary Institute of Cancer Research

Université Constantine 2

Centre National de la Recherche Scientifique

University of Ferrara

University of Lisbon

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Acción del nitrato de plata sobre lactonas sesquiterpénicas cloradas

A. G. González Jaime Bermejo Guillermo M. Massanet Juan M. Amaro

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Transformación química de la vulgarina en 8-deoximelitensina y castellanina

Antonio G. González Jaime Bermejo Jesús G. Dı́az T. Zaragoza

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Lignans and an abundant flavone glycoside with free-radical scavenging activity from the roots of the endemic species Stachys mialhesi de Noé

S. Laggoune Ignacio Brouard Francisco León Claude-Alain Calliste Jean-luc Duroux Duroux

Scavenging

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Bioactive humulene derivatives from Asteriscus vogelii

Phytochemistry (2001)

Amélia P. Rauter Isabel Branco Jaime Bermejo Antonio González M. D. GARCIA‐GRAVALOS

Humulene

Human lung

10.1016/s0031-9422(00)00304-6

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Evaluation of Hepatoprotective Effect of Artimesia Monosperma Against Carbon Tetrachloride-induced Hepatic Damage Rat

Sayed A. El‐Toumy Enayat A. Omara Ignacio Brouard Jaime Bermejo

The hepatoprotective effect of aqueous ethanol extract of Artimesia monosperma aerial parts was investigated against carbon tetrachloride-induced acute hepatotoxicity in rat. The hepatoprotective activity of A. monosperma was evaluated by determination of liver enzyme markers in the serum (aspartat amino transferase AST; serum alanine transaminase ALT and alkaline phosphatase ALP). The histopathological studies were also carried out to support the above parameters. Oral administration of A. monosperma (100 and 200 mg/kg) markedly reduced the elevated values of AST, ALT and ALP caused by CCl4 treatment. Glutathione (GSH) significantly decreases in the group treated with CCl4. A. monosperma (two doses) and silymarin significantly increased GSH levels when they administrated with CCl 4 . However, silymarin normalized liver enzymes and increased GSH levels than A. monosperma (two doses) when compared with the control group. Histopathological results revealed that A. monosperma treatment with its two doses exhibited almost normal architecture, compared to CCl4-treated group. Image analysis of liver revealed a marked reduction in liver damage area after treatment with A. monosperma (100 or 200 mg/kg) and silymarin compared with CCl4-treated group. A phytochemical study of A. monosprema resulted in the isolation of a quercetin 3-O-β- glucopyranoside; quercetin 5-O-β-glucopyranoside; isorhamnetin 3-O-β-glucopyranoside; 5, 4' - dihydroxy 6, 7-dimethoxy flavone; 5, 3' - dihydroxy 6, 7, 4'- trimethoxy flavone; 5, 7, 3' - trihydroxy 3, 6, 4' - trimethoxy flavone; quercetin and isorhamnetin. Structures of the isolated compounds were established by chromatography, UV and 1D/2D 1 H' 13 C spectroscopy. Hepatoprotective effect of A. momosperma is probably due to combined effect of flavonoids.

CCL4

Aspartate transaminase

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Chemotaxonomy of Gonospermum and related genera

Phytochemistry (2010)

Jorge Triana José Luis Eiroa Juan José Ortega Francisco León Ignacio Brouard

Chemotaxonomy

Sesquiterpene lactone

Monophyly

10.1016/j.phytochem.2009.12.013

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Isolation, Structure Elucidation, Total Synthesis, and Evaluation of New Natural and Synthetic Ceramides on Human SK-MEL-1 Melanoma Cells

Journal of Medicinal Chemistry (2006)

Francisco León Ignacio Brouard Augusto Rivera Fernando Torres Sara Rubio

Two new long-chain ceramides, trametenamides A (1) and B (2), were isolated from the methanolic extract of the fruiting body of the fungus Trametes menziesii. The structures were elucidated by spectroscopic analyses and chemical transformations, and the absolute stereochemistry of trametenamide B (2) was determined by stereoselective total synthesis of four possible diastereomers. The acetyl derivative of the natural ceramide (1a) and synthetic ceramides (24-27) showed cytotoxicity on the human melanoma cell line SK-MEL-1, which was caused by induction of apoptosis as determined by DNA fragmentation, poly(ADP-ribose) polymerase cleavage, and procaspase-9 and -8 processing.

Isolation

10.1021/jm0605334

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Citations (17)

ChemInform Abstract: 4β,15‐Dihydro‐3‐dehydrosolstitialin A.

ChemInform (2000)

Javier González‐Platas Catalina Ruíz-Pérez Antonio González Jaime Bermejo Kamel Medjroubi

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.200007162

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Citations (3)

A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides

Fitoterapia (2007)

Amélia P. Rauter Isabel Branco Rui G. Lopes Jorge Justino Filipa Silva

Salvia

10.1016/j.fitote.2007.02.013

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Citations (56)

Synthesis and Antiproliferative Activity of a New Compound Containing an α-Methylene-γ-Lactone Group

Journal of Medicinal Chemistry (2002)

Antonio G. González Margarita Hernández Silva Juan I. Padrón Francisco León Eduardo Reyes

The biological activity of compound 9 obtained by introducing an α-methylene-γ-butyrolactone group into 3-(4-hydroxyphenyl)propionic acid, 1, was studied for possible effects on HL-60 cells, murine splenocytes, and human peripheral mononuclear cells (PBMC). 9 induced apoptosis in the HL-60 cell line and has a clear capacity to inhibit proliferation induced in murine splenocytes and PBMC by different mitogenic agents with no apparent toxic side effects. 9 was synthesized from 1, and its structure and stereochemistry were elucidated by spectroscopic methods.

Methylene

10.1021/jm025518n

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Citations (47)