Alireza Baradaran‐Rafii

University of South Florida

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Saeed Heidari Keshel

Shahid Beheshti University of Medical Sciences

Medi Eslani

University of California, San Diego

Farid Karimian

Shahid Beheshti University of Medical Sciences

Sepehr Feizi

Shahid Beheshti University of Medical Sciences

Ali R. Djalilian

University of Illinois Chicago

Esmaeil Biazar

Islamic Azad University Tonekabon

Mohammad‐Ali Javadi

Shahid Beheshti University of Medical Sciences

Antonio Elizondo

Ocular Surface Center

Danial Roshandel

Lions Eye Institute

Bahram Einollahi

Shahid Beheshti University of Medical Sciences

Cooperative Institutions

Shahid Beheshti University of Medical Sciences

123

Tehran University of Medical Sciences

Shahid Beheshti University

Iran University of Medical Sciences

University of Tehran

Hospital Labbafinejad

Mashhad University of Medical Sciences

Ocular Surface Center

University of Illinois Chicago

Farabi Hospital

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Derivation of epithelial-like cells from eyelid fat-derived stem cells in thermosensitive hydrogel

Journal of Biomaterials Science Polymer Edition (2015)

Saeed Heidari Keshel Maryam Rostampour Golbahar Khosropour Atefehsadat Bandbon B Alireza Baradaran‐Rafii

Injectable hydrogel is one of the great interests for tissue engineering and cell encapsulation. In the study, the thermosensitive chitosan/gelatin/β-glycerol phosphate (C/G/GP) disodium salt hydrogels were designed and investigated by different analyses. The eye fat-derived stem cells were used to evaluate the biocompatibility of hydrogels based on their phenotypic profile, viability, proliferation, and attachment ability. The results show that the sol/gel transition temperature of the C/G/GP hydrogel was in the range of 31.1-33.8 °C at neutral pH value, the gelation time was shortened, and the gel strength also improved at body temperature when compared with the C/GP hydrogel. In vitro cell culture experiments with eyelid fat-derived stem cells in hydrogel showed beneficial effects on the cell phenotypic morphology, proliferation, and differentiation. Microscopic figures showed that the eyelid fat stem cell were firmly anchored to the substrates and were able to retain a normal stem cell phenotype. Immunocytochemistry (ICC) and real-time-PCR results revealed change in the expression profile of eyelid fat stem cells grown with hydrogels when compared to those grown on control in epithelial induction condition. This study indicates that using chitosan/gelatin/β-glycerol phosphate hydrogel for cell culture is feasible and may apply in minimal invasive surgery in the future.

Gelatin

Biocompatibility

10.1080/09205063.2015.1130406

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Bilateral Bacterial Keratitis in Three Patients Following Photorefractive Keratectomy

Journal of Refractive Surgery (2007)

Farid Karimian Alireza Baradaran‐Rafii MohammadAli Javadi R Nazari Hossein Mohammad-Rabei

ABSTRACT PURPOSE: To report clinical manifestations and the bactériologie profiles of three patients with bilateral bacterial keratitis following photorefractive keratectomy (PRK). METHODS: Photorefractive keratectomy was performed for mild to moderate myopia or compound myopic astigmatism. Bandage contact lenses were fitted at the conclusion of each surgery. Bilateral infectious keratitis was diagnosed within 3 days after surgery. Smear and culture were obtained in all three cases. Patients were treated with topical fortified antibiotics (cefazolin and gentamicin). RESULTS: All patients presented with severe bilateral ocular pain, photophobia, purulent discharge, and dense corneal infiltration. Causative organisms were Staphylococcus aureus (n=2) and Streptococcus pneumoniae (n=l). Ulcers were controlled with aggressive medical therapy in five eyes; however, tectonic penetrating keratoplasty was required in one eye. CONCLUSIONS: Uncontrolled blepharitis and bandage contact lens use appears to play a role in the development of bacterial keratitis after PRK. Avoidance of simultaneous bilateral surgery in patients with risk factors for bacterial keratitis, preoperative control of blepharitis, and good contact lens hygiene is suggested. [J Refract Surg. 2007;23:312-315.]

Photophobia

Cefazolin

10.3928/1081-597x-20070301-18

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New advances in medical management of dry eye: optimizing treatment strategies for enhanced relief

International Ophthalmology (2024)

Toktam Shahraki Alireza Baradaran‐Rafii Ramesh S. Ayyala Amir Arabi John S Jarstad

Artificial tears

Meibomian gland

Pathophysiology

Review article

10.1007/s10792-024-02978-1

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Double-Ring Sign to Confirm Correct Orientation of Donor Lenticules During Descemet Stripping Automated Endothelial Keratoplasty

Cornea (2015)

Siamak Delfazayebaher Sepehr Feizi Mohammad Ali Javadi Alireza Baradaran‐Rafii Mohammad Mehdi Sadoughi

To describe a sign that can confirm the correct position of donor lenticules during Descemet stripping automated endothelial keratoplasty (DSAEK).In this clinical and laboratory study, DSAEK was performed in 3 eyes with a diagnosis of pseudophakic bullous keratopathy. Additionally, 2 whole globes and 2 precut corneoscleral buttons were procured for the purpose of the laboratory part of the study. After removal of recipient Descemet membrane, the donor graft was inserted into the anterior chamber, unfolded, and attached to the posterior corneal stroma with an air bubble. A similar procedure was performed in the eye-bank eyes with lenticules attached in both correct and upside-down orientations.After the anterior chamber was completely filled with air, 2 or more concentric shiny rings were formed at the border of the donor lenticule because of total internal reflection in the graft. In the live and eye-bank eyes with a donor graft attached in the correct orientation, the innermost shiny ring, indicating the stromal side of the graft, was observed under the recipient cornea, whereas the outermost ring, indicating the endothelial side, was formed deeper. When the donor lenticule was intentionally implanted upside down in the eye-bank eyes, the reverse situation occurred, and the largest ring was observed just beneath the recipient cornea.The correct anterior-posterior orientation of the donor lenticule during DSAEK could be identified by the shiny rings formed at the border of the graft after the anterior chamber was completely filled with air.

Eye bank

Descemet membrane

Air bubble

10.1097/ico.0000000000000485

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Citations (9)

ZNF797 plays an oncogenic role in gastric cancer

Genetics and Molecular Research (2014)

Daruosh Momenzadeh S. Rahmanzadeh Mostafa Rezaei‐Tavirani Alireza Baradaran‐Rafii Fariba Ghasemvand

cancers, SALL4 is introduced as a potentially interesting therapeutic target to reverse a number of aberrations that promote gastric tumor development and maintenance.This result may lead to new approaches for cancer therapy.

Tumor progression

10.4238/2014.october.20.18

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Citations (4)

Oxygen Therapy for Acute Ocular Chemical or Thermal Burns: A Pilot Study

American Journal of Ophthalmology (2011)

Farideh Sharifipour Alireza Baradaran‐Rafii ‪Esmaeil Idani Mitra Zamani Mohammad Hossein Jabbarpoor Bonyadi

Symblepharon

Oxygen therapy

10.1016/j.ajo.2010.11.005

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Citations (32)

Electrospun mat with eyelid fat-derived stem cells as a scaffold for ocular epithelial regeneration

Artificial Cells Nanomedicine and Biotechnology (2016)

Daruosh Momenzadeh Alireza Baradaran‐Rafii Saeed Heidari Keshel Maryam Ebrahimi Esmaeil Biazar

The aim of this study was to develop nanofibrous gelatin substrates for eyelid fat stem cell (EFSC) expansion that can serve as a potential alternative substrate to replace human amniotic membrane. Biocompatibility results indicated that all substrates were highly biocompatible, as EFSCs could favorably attach and proliferate on the nanofibrous surfaces. Microscopic figures showed that the EFSC were firmly anchored to the substrates and were able to retain a normal stem cell phenotype. Immunocytochemistry (ICC) and real time-PCR results revealed change in the expression profile of EFSCs grown on nanofibrous substrates when compared to those grown on control in epithelial induction condition. In addition, electrospun gelatin mats especially oriented scaffold provides not only a milieu supporting EFSCs expansion, but also serves as a useful alternative carrier for ocular surface tissue engineering and could be used as an alternative substrate to amniotic membrane.

Gelatin

Biocompatibility

10.3109/21691401.2016.1138483

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Citations (28)

Cell-based approaches towards treating age-related macular degeneration

Cell and Tissue Banking (2020)

Alireza Baradaran‐Rafii Masoumeh Sarvari Sepideh Alavi-Moghadam Moloud Payab Parisa Goodarzi

Degeneration (medical)

Regenerative Medicine

10.1007/s10561-020-09826-3

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Citations (14)

The Tear Film Breaks Up From the Lipid Tear Film by Condensation: Evidence Provided by Kinetic Tear Interference Analysis

Investigative Ophthalmology & Visual Science (2005)

Mario A. Di Pascuale Antonio Elizondo Yingying Gao Alireza Baradaran‐Rafii Chin-Liang Kuo

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Mitomycin-C Trabeculectomy versus Ahmed Glaucoma Implant in Pediatric Aphakic Glaucoma

DOAJ (DOAJ: Directory of Open Access Journals) (2008)

Mohammad Pakravan Homayoun Nikkhah Alireza Baradaran‐Rafii Shahin Yazdani

Methods: In a randomized clinical trial, 30 eyes of 28 children <16 years of age who had undergone anterior lensectomy-vitrectomy for congenital cataract were assigned to MMC-T (15 eyes of 13 children) or AGI (15 eyes of 15 children). Surgical success was classified as complete (IOP 6-21 mmHg without any antiglaucoma medication) and partial (IOP 6-21 mmHg with <2 topical antiglaucoma agents) in the absence of any sight-threatening complication or need for further glaucoma surgery, stable cup/disc ratios and visual loss <2 Snellen lines. Overall success was defined as the sum of complete and partial success. Results: Mean patient age was 9.1±4.1 and 10.9±5.1 years in the MMC-T and AGI groups, respectively (P=0.29). After a mean follow up of 14.8±11 and 13.1±9.7 months; complete, partial and overall success rates were 33.3%, 40% and 73.3% in the MMC-T vs 20%, 66.7% and 86.7% in the AGI groups, respectively (P= 0.361). Complication and failure rates were 40% and 26.7% in the MMC-T group vs 26.7% and 13.3% in the AGI group, respectively (P= 0.439). Conclusion: MMC-T and AGI seem to be comparable in terms of success and complications as the initial surgical procedure in pediatric aphakic glaucoma. Choice of either technique depends on surgeon’s experience and conjunctival quality and mobility.

Mitomycin C

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