In Sup Noh

National University of Technology

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Mi‐Sook Kim

Korea Institute of Radiological and Medical Sciences

Yoon Jeong Choi

Seoul National University Bundang Hospital

Gun Woo Kim

Kyungpook National University Hospital

In Sook Kim

Seoul National University

Kyu Back Lee

Korea University

Yongdoo Park

Korea University

Soon Jung Hwang

Seoul National University Dental Hospital

Elazer R. Edelman

Brigham and Women's Hospital

Kwang Meyong Kim

Korea Institute of Science and Technology

Young Sook Son

Kyungpook National University

Cooperative Institutions

Seoul National University

Korea Institute of Science and Technology

Yonsei University

Korea University

Korea Institute of Radiological and Medical Sciences

Seoul National University Hospital

Kyungpook National University

Korea University Medical Center

Seoul National University of Science and Technology

Kangwon National University

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Smooth Muscle Cell Ingrowth of a Surface-Modified ePTFE Vascular Graft

Key engineering materials (2005)

In Sup Noh Elazer R. Edelman

A variety of attempts have been made to improve small diameter expanded polytetrafluoroethylene (ePTFE) vascular grafts through cellular and tissue engineering. Some of these techniques have made their way into clinical trials. Coating of endothelial cells via surface modifications has increased graft patency in some hands but lack of firm adhesion of the seeded cells on the graft surface can lead to graft failures. We increased cell-graft and graft-tissue interactions by inducing smooth muscle cell growth into the pores of the graft wall through chemical modification of superficial surfaces, including those of the transmural pores. In contrast to non-modified surfaces seeded cells adhered on and proliferated into the modified pores and internodal surfaces. Cellular growth into these critical pores spaces seemed to arise from surface modification including defluorination and oxygenation incorporation leading to changes in chemical composition, surface tension, cell-surface interaction and modified surface fibril aggregation.

Surface Modification

Polytetrafluoroethylene

10.4028/www.scientific.net/kem.288-289.367

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Citations (2)

A Novel Method for Porous Chitosan Scaffold

Key engineering materials (2007)

Jin Ik Lim Gun Woo Kim Jae Sik Na In Sup Noh Young Sook Son

This study is to develop a novel method for preparation of the chitosan scaffold having interconnected open pore structure and controlled pore distribution. For this, the effects of addition of non-solvent on chitosan solution were estimated. The porous scaffolds were typically prepared by solid-liquid separation and subsequent sublimation of solvent. Alcohol was used as non-solvent for chitosan. The difference of freezing temperature of each of the components induced the liquidliquid and the liquid-solid phase separation via demixing solution (solvent/non-solvent/chitosan). The morphology, heterogeneous pore distribution and mechanical properties of the scaffolds were examined. The addition of non-solvent in chitosan solution was to make the controlled homogeneous micropores and improved interconnectivity between pores without any surface skin layer. For control chitosan scaffold, the pore size was mainly about 80~100 μm. On the contrary, Pore diameters could be controlled mainly within the range 30~100 μm, with a variation of solvent/non-solvent ratio. The number of minute pore (4~25 μm) over chitosan scaffold increased with increasing ratio of non-solvent. New prepared scaffold exhibited larger value of breaking elongation, more elasticity, but less tensile strength than that of control scaffold.

Interconnectivity

Elongation

Sublimation

10.4028/www.scientific.net/kem.342-343.65

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Citations (6)

Characterization of Hyaluronic Acid-Poly(Ethylene Oxide) Hydrogel Dependent upon Poly(Ethylene Oxide)

Key engineering materials (2007)

Mi‐Sook Kim Yoon Jeong Choi Gun Woo Kim In Sup Noh Yongdoo Park

Poly ethylene

Characterization

10.4028/0-87849-436-7.749

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Characterization of Hyaluronic Acid-Poly(Ethylene Oxide) Hydrogel Dependent upon Poly(Ethylene Oxide)

Key engineering materials (2007)

Mi‐Sook Kim Yoon Jeong Choi Gun Woo Kim In Sup Noh Yongdoo Park

Characterization of an hyaluronic acid (HA)-poly(ethylene oxide) (PEO) hydrogel was performed by changing the number of side arms in a PEO molecule. Verification of grafting chemistry and mechanical strength, as well as swelling behaviors and surface morphologies of the HA-PEO hydrogels were analyzed by employing different x-linking molecular weights (MW) of PEO ranging from 1.7 to 5.0 kDa at a fixed low MW HA in the hydrogel network. Methacrylation to the HA successfully obtained via Michael type reaction between the methacrylate arm groups in HA and the thiol end groups in PEO was observed by XPS. Hydrogel formation was markedly dependent upon the numbers of thiol groups in the PEO molecule. Furthermore the lower MW PEO-based HA hydrogel demonstrated stronger mechanical properties but lower water absorption and the smaller pore sizes on its surface and cross section.

Poly ethylene

10.4028/www.scientific.net/kem.342-343.749

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Release Profile of a Model Protein Drug Depending on the Stability of Microspheres Based on Polyelectrolyte Complex

Key engineering materials (2007)

Sung Won Kim Yun Sik Nam Yeon Jin Min Jong Ho Kim Kwang Meyong Kim

10.4028/0-87849-436-7.505

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Tissue Regeneration of a Hybrid Vascular Graft Composed of Biodegradable Layers and Non-Biodegradable Layer by Static and Pulsatile Flows

Key engineering materials (2007)

Yoon Jeong Choi Mi‐Sook Kim In Sup Noh

Clinical applications of expanded polytetrafluoroethylene (ePTFE) as a small diameter graft have been limited due to its limited patency rates, even though its demands are high. After fabricating the biodegradable PLGA layers on both the inside and outside of ePTFE, long-term in vitro smooth muscle cell culture was performed on the luminal scaffold surface. The fabricated hybrid ePTFE scaffolds were designed to have three distinctive layers and porous structures in the biodegradable layers generated by gas-foaming of the ammonium bicarbonate porogens, i.e. two layers of poly(lactide-co-glycolide) (PLGA) as biodegradable layers for tissue engineering and an ePTFE layer in the middle as a non-biodegradable layer. We evaluated the regenerated vascular tissues after applying either static or pulstile flow on a smooth muscle cells-seeded hybrid scaffold. Analysis of the engineered tissues was performed with SEM for morphological observation and H&E staining for observation of tissue development dependent upon a mode of culture system, flow patterns and scaffold species.

PLGA

Pulsatile flow

Ammonium bicarbonate

10.4028/www.scientific.net/kem.342-343.61

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Citations (1)

A Novel Method for Porous Chitosan Scaffold

Key engineering materials (2007)

Jin Ik Lim Gun Woo Kim Jae Sik Na In Sup Noh Young Sook Son

10.4028/0-87849-436-7.65

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Citations (1)

Vascular Tissue Regeneration of the Hybrid ePTFE Graft for Adult Patients

Key engineering materials (2005)

In Sup Noh

Vascular graft

10.4028/0-87849-967-9.55

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Citations (0)

Effect of Hydroxyapatite-Tricalcium Phosphate Micro-Particles on the Cellular Interaction of In Situ Hyaluronic Acid-Poly(Ethylene Oxide) Hydrogel

Key engineering materials (2007)

Mi‐Sook Kim Yoon Jeong Choi Gun Woo Kim In Sup Noh Yongdoo Park

Poly ethylene

10.4028/0-87849-436-7.765

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Evaluation of Acid-Treated Hyaluronic Acid-Based Hydrogelation

Key engineering materials (2007)

Mi‐Sook Kim Yoon Jeong Choi Gun Woo Kim In Sup Noh Yongdoo Park

Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it’s long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.

Gel permeation chromatography

Poly ethylene

10.4028/www.scientific.net/kem.342-343.745

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Citations (1)