Françoise Sauriol

Queen's University

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Qing‐Wen Shi

Nanjing Boiler and Pressure Vessel Inspection Institute

Yu‐Cheng Gu

Syngenta (United Kingdom)

Lolita O. Zamir

Centre National pour la Recherche Scientifique et Technique (CNRST)

Mei Dong

Public Health Ontario

Hiromasa Kiyota

Okayama University

Suning Wang

Second Hospital of Shandong University

Orval Mamer

McGill University Health Centre

Yibing Wu

Hebei Medical University

Zhi‐Yu Ni

Affiliated Hospital of Hebei University

Soren K. Mellerup

Queen's University

Cooperative Institutions

Hebei Medical University

Queen's University

McGill University

Institut National de la Recherche Scientifique

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Shijiazhuang University

National Research Council Canada

Beijing Institute of Technology

Université du Québec à Montréal

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ChemInform Abstract: KONFORMATION VON 2,2,5,5‐TETRAMETHYL‐CYCLOHEXANDION‐(1,3)‐DERIVATEN

Chemischer Informationsdienst (1973)

Michel Bernard Françoise Sauriol M. St-Jacques

10.1002/chin.197307080

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Rearrangement of the major taxane from Taxus canadensis

Tetrahedron Letters (1996)

Lolita O. Zamir Yi Zheng Gaétan Caron Françoise Sauriol Orval Mamer

Taxane

Sequence (biology)

10.1016/0040-4039(96)01426-8

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Citations (11)

Antiandrogenic, Maspin Induction, and Antiprostate Cancer Activities of Tanshinone IIA and Its Novel Derivatives with Modification in Ring A

Journal of Medicinal Chemistry (2011)

Weiguo Liu Jinming Zhou Guoyan Geng Qing‐Wen Shi Françoise Sauriol

Expression of metastatic suppressor maspin is lost in advanced prostate cancer. Clinically relevant mutations in androgen receptor (AR) convert antiandrogens into AR agonists, promoting prostate tumor growth. We discovered tanshinone IIA (TS-IIA) is a potent antagonist of mutated ARs and induces maspin expression through AR. TS-IIA suppressed AR expression and induced apoptosis in LNCaP cells. Syntheses of TS-IIA derivatives (1–9) revealed that the 4,4-dimethyl group at ring A is important for TS-IIA's antiandrogenic and maspin induction activities.

Maspin

Antiandrogens

10.1021/jm2015292

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Citations (47)

A new alkaloid taxane composed of two N-formyl rotamers from the rooted cuttings of Taxus canadensis

Chemistry of Natural Compounds (2013)

Hong-Zhen Zhang Yu‐Fang Wang Man‐Li Zhang Mei Dong Chang‐Hong Huo

Conformational isomerism

Taxane

10.1007/s10600-013-0458-7

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Citations (6)

A New Taxane with a 4β,20-Epoxy Ring from the Rooted Cuttings of Taxus canadensis

Chemistry of Natural Compounds (2013)

Gen-Dong Yao Hongfeng Zhang Yun Huang Françoise Sauriol Qing‐Wen Shi

Taxane

Cutting

10.1007/s10600-013-0765-z

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Citations (1)

Triaryl-Boron Functionalized Dinuclear Platinum Complexes Linked by Photoisomerizable Bpe Ligand: Luminescence and Isomerism

Inorganic Chemistry (2017)

Nan Wang Ming‐Feng Hu Soren K. Mellerup Xiang Wang Françoise Sauriol

We report herein a series of triarylboron-functionalized Pt(II) dinuclear complexes using a photoactive bis(4-pyridyl)ethylene (bpe) bridging unit. The new Pt(II) complexes display phosphorescence at both room temperature and 77 K. Depending on the conditions under which crystals of the complexes were grown, either the cis- or trans-isomers could be obtained. The trans and cis isomers were found to undergo light-induced isomerization in solution with the trans isomer being the dominant species.

Cis–trans isomerism

10.1021/acs.inorgchem.7b01535

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Citations (11)

Conformation of derivatives of 2,2,5,5-tetramethylcyclohexane-1,3-dione

Journal of the American Chemical Society (1972)

Michel Bernard Françoise Sauriol Maurice St. Jacques

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformation of derivatives of 2,2,5,5-tetramethylcyclohexane-1,3-dioneMichel Bernard, Francoise Sauriol, and Maurice St. JacquesCite this: J. Am. Chem. Soc. 1972, 94, 24, 8624–8626Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/ja00779a079https://doi.org/10.1021/ja00779a079research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

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10.1021/ja00779a079

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Citations (3)

CCDC 1549496: Experimental Crystal Structure Determination

The Cambridge Structural Database (2017)

Nan Wang Ming‐Feng Hu Soren K. Mellerup Xiang Wang Françoise Sauriol

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1p0crt

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Novel quinazolinones and enniatins from Fusarium lateritium Nees

Canadian Journal of Chemistry (1993)

Youla S. Tsantrizos Xiao-Jin Xu Françoise Sauriol Rosemary C. Hynes

Fusarium lateritium Nees is a natural antagonist of the plant pathogen Eutypa armeniacae. In an effort to show that this biological phenomenon is chemically mediated, the bioactive metabolites of F. lateritium were investigated. The cytotoxic alkaloids 2-(1-hydroxyethyl)-4(3H)quinazolinone (1) and 2-acetyl-4(3H)quinazolinone (2), and the three cyclohexadepsipeptides, enniatins B (3), B 1 (4), and A 1 (5), were isolated and characterized. Metabolites 3, 4, and 5 were found to exhibit strong antifungal activity against E. armeniacae. The structures of the novel metabolites 1 and 2 were elucidated by spectroscopic analysis and that of 2 was confirmed by X-ray crystallography. The absolute stereochemistry of 1 was investigated by 1 H and I9 F NMR analysis of its Mosher ester derivative.

Quinazolinone

Derivative (finance)

Beauvericin

10.1139/v93-176

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Citations (34)

Taxanes in rooted cuttings vs. mature Japanese yew

Canadian Journal of Chemistry (2003)

Qing‐Wen Shi Tracy L. Petzke Françoise Sauriol Orval Mamer Lolita O. Zamir

Two novel taxanes were identified from rooted cuttings of the Japanese yew, Taxus cuspidata Sieb. et Zucc. Their structures were characterized as taxa-4(20),11-dien-2α,5α-diacetate-14β-(2'S,3'R)-3'-hydroxy-2'-methylbutyrate-10-β-glucoside (1) and 2α,5α,9α,10β-tetraacetoxy-13α-(Z)-cinnamoyloxy-taxa-4(20),11-diene (2). In addition, metabolites 343 were also characterized in the same cuttings. Taxanes 316 as well as three non-taxane metabolites (1719) have not previously been reported in the needles, stems, seeds, or bark of the mature T. cuspidata plant, although they have been found in other yews. The known taxanes 2043 were also detected for the first time in the rooted cuttings of the Japanese yew. Key words: Taxus cuspidata, Taxacae, taxanes, rooted cuttings, metabolites.

Cutting

Taxane

10.1139/v02-190

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Citations (11)