Yun Wu

Guangxi Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Rongmeng Tian

Beijing Jiaotong University

Bonan Lin

Beijing Jiaotong University

Jiang Hu

Harvard University

Zhijie Chang

Tsinghua University

Guosheng Jiang

China University of Geosciences

Wanghua Gong

Osaka University

Wanli Zhai

Jiangsu Yonggang Group (China)

Yuqi He

South China Normal University

Youyong Lu

Peking University Cancer Hospital

Lang Yang

Chinese PLA General Hospital

Cooperative Institutions

The University of Texas MD Anderson Cancer Center

Sun Yat-sen University

Chinese Academy of Sciences

Harvard University

Anhui Medical University

Peking University

Shanghai Jiao Tong University

Dana-Farber Cancer Institute

University of Chinese Academy of Sciences

Sichuan University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Data from Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer

Yi‐Hsin Hsu Jun Yao Li-Chuan Chan Ting-Jung Wu Jennifer L. Hsu

<div>AbstractTriple-negative breast cancer (TNBC) is a highly heterogeneous and recurrent subtype of breast cancer that lacks an effective targeted therapy. To identify candidate therapeutic targets, we profiled global gene expression in TNBC and breast tumor-initiating cells with a patient survival dataset. Eight TNBC-related kinases were found to be overexpressed in TNBC cells with stem-like properties. Among them, expression of PKC-α, MET, and CDK6 correlated with poorer survival outcomes. In cases coexpressing two of these three kinases, survival rates were lower than in cases where only one of these kinases was expressed. In functional tests, two-drug combinations targeting these three kinases inhibited TNBC cell proliferation and tumorigenic potential in a cooperative manner. A combination of PKC-α-MET inhibitors also attenuated tumor growth in a cooperative manner in vivo. Our findings define three kinases critical for TNBC growth and offer a preclinical rationale for their candidacy as effective therapeutic targets in treating TNBC. Cancer Res; 74(17); 4822–35. ©2014 AACR.</div>

Triple-negative breast cancer

Cyclin-dependent kinase 6

10.1158/0008-5472.c.6506478.v1

Cite

Citations (0)

High-Voltage β-Ga₂O₃ RF MOSFETs With a Shallowly-Implanted 2DEG-Like Channel

IEEE Electron Device Letters (2023)

Xinxin Yu Hehe Gong Jianjun Zhou Zhenghao Shen Wenhui Xu

We report radio-frequency (RF) MOSFETs with a two-dimensional-electron-gas-like (2DEG-like) channel formed at the

$\beta $

-Ga ₂ O ₃ surface through the low-energy implantation of Si and rapid thermal activation process. The shallowly implanted channel exhibits a strong electron confinement near surface with a high sheet concentration of

${3}.{2}\times {10} ^{{13}}$

cm ⁻³ . With the high scaling of gate length (

${L}_{\text {G}}{)}$

, the current cut-off frequency (

${f}_{\text {T}}{)}$

and maximum oscillation frequency (

${f}_{\text {max}}{)}$

were inversely proportional to

${L}_{\text {G}}$

along with a high electron saturation velocity of

${2}.{7}\times {10} ^{{6}}$

cm/s. The device with a

${L}_{\text {G}}$

$0.15 ~\mu \text{m}$

demonstrates a high

${f}_{\text {T}}$

of 29 GHz and

${f}_{\text {max}}$

of 35 GHz, whilst preserving the high-voltage operation capability with a drain-to-source breakdown voltage (

$BV_{\text {DS}}{)}$

of 193 V. RF performance was verified by the power amplifying capability with a maximum power gain of 7 dB at 2 GHz for the device with

${L}_{\text {G}}$

$0.5~\mu \text{m}$

10.1109/led.2023.3282454

Cite

Citations (7)

Supplementary Table 2 from Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer

Sangjun Lee Sheila A. Stewart Irıs D. Nagtegaal Jingqin Luo Yun Wu

XLS file - 85K, Supervised Comparisions of 5 independent groups to identify differentially expressed genes that may be associated with progression of DCIS to IBC

10.1158/0008-5472.22391769

Cite

Citations (0)

Supplementary Figure 3 from Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer

Sangjun Lee Sheila A. Stewart Irıs D. Nagtegaal Jingqin Luo Yun Wu

PDF file - 118K, In Vitro Results (impact of gene knockdown on the ability of cells to grow)

10.1158/0008-5472.22391784

Cite

Citations (0)

Supplementary Table 3 from Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer

Sangjun Lee Sheila A. Stewart Irıs D. Nagtegaal Jingqin Luo Yun Wu

XLS file - 128K, Summary of Ontologies associated with differentially expressed genes

10.1158/0008-5472.22391766

Cite

Citations (0)

Supplementary Figure 3 from Breast Cancer Cell Uptake of the Inflammatory Mediator Neutrophil Elastase Triggers an Anticancer Adaptive Immune Response

Elizabeth A. Mittendorf Gheath Alatrash Na Qiao Yun Wu Pariya Sukhumalchandra

PDF file - 123K, Confocal immunoflourescence microscopy images showing localization of neutrophil elastase in distinct compartments following uptake

Neutrophil elastase

Mediator

Neutrophil Extracellular Traps

10.1158/0008-5472.22391709

Cite

Citations (0)

Supplementary Figure 4 from Inhibition of Lipocalin 2 Impairs Breast Tumorigenesis and Metastasis

Xiaohong Leng Tian Ding Hui Lin Yan Wang Limei Hu

Supplementary Figure 4 from Inhibition of Lipocalin 2 Impairs Breast Tumorigenesis and Metastasis

Breast cancer metastasis

10.1158/0008-5472.22382558.v1

Cite

Citations (0)

Supplementary Figure 2 from Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

Yuhua Zhao Hao Liu Zixing Liu Yan Ding Susan P. LeDoux

Supplementary Figure 2 from Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

Carbohydrate Metabolism

10.1158/0008-5472.22388657.v1

Cite

Citations (0)

Supplementary Figure 4 from PD-L1 Expression in Triple-Negative Breast Cancer

Elizabeth A. Mittendorf Anne V. Philips Funda Meric‐Bernstam Na Qiao Yun Wu

PDF file - 110K, Supplementary figure 4. T cell's undergo apoptosis after co-culture with MDA-MB-231 breast cancer cells following PTEN knockdown To determine the effect of increased PD-L1 cell surface expression on apoptosis, standard annexin V assays were performed. Anti-CD3/CD28-stimulated PBMC were co-cultured with breast cancer cells for 20 hours and then stained with anti-CD4 and anti-CD8 antibodies and resuspended in Annexin binding buffer. Analysis was performed using flow cytometry gating on CD4+ or CD8+ T cells. A representative histogram from one experiment is shown in panel A. The experiment was repeated three times in triplicate and the percent Annexin V positive CD4+ and CD8+ T cells from one experiment is shown in panel B.

10.1158/2326-6066.22536965.v1

Cite

Citations (0)

Supplementary Methods from A Systems Biology Approach Identifies Effective Tumor–Stroma Common Targets for Oral Squamous Cell Carcinoma

Wenxia Meng Yun Wu Feng He Chuanxia Liu Qinghong Gao

PDF file - 85K

10.1158/0008-5472.22402185.v1

Cite

Citations (0)