Roop K. Khar

Hamdard University

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Farhan Jalees Ahmad

Jamia Hamdard

Gaurav Jain

Indian Institute of Technology Roorkee

Sushama Talegaonkar

Delhi Pharmaceutical Science and Research University

Sohail Akhter

Institute of Water Modelling

Shadab A. Pathan

Hamad Medical Corporation

Syed Mohd Abbas Zaidi

Z.V.M.Unani Medical College & Hospital

Ankur Sharma

All India Institute of Medical Sciences Jodhpur

Arvind K. Bansal

National Institute of Pharmaceutical Education and Research

Jayabalan Nirmal

Birla Institute of Technology and Science, Pilani

Gaurav Mittal

Mahatma Gandhi Institute of Medical Sciences

Cooperative Institutions

Jamia Hamdard

Hamdard University

Delhi Pharmaceutical Science and Research University

Institute of Nuclear Medicine & Allied Sciences

Weatherford College

Aligarh Muslim University

Pharmac

American Pharmacists Association

Institute of Medical Sciences

Defence Research and Development Organisation

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Mechanistic study of hydrolytic erosion and drug release behaviour of PLGA nanoparticles: Influence of chitosan

Polymer Degradation and Stability (2010)

Gaurav Jain Shadab A. Pathan Sohail Akhter Niyaz Ahmad Nilu Jain

PLGA

Particle (ecology)

10.1016/j.polymdegradstab.2010.08.015

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Citations (51)

Phytotherapeutic potential of tea tree essential oil in vitro and emerging vistas in the skincare industry: a comprehensive review.

Md. Faiyazuddin Shalini Suri Gulam Mustafa Zahid Iqbal Sushama Talegaonkar

Tree (set theory)

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Citations (0)

Microscopic and spectroscopic evaluation of novel PLGA–chitosan Nanoplexes as an ocular delivery system

Colloids and Surfaces B Biointerfaces (2010)

Gaurav Jain Shadab A. Pathan Sohail Akhter Jayabalan Nirmal Sushama Talegaonkar

PLGA

10.1016/j.colsurfb.2010.09.010

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Citations (69)

Benzyl ester prodrug of ibuprofen: pharmacological and toxicological profile.

PubMed (2001)

Arvind K. Bansal Roop K. Khar R Dubey Ankur Sharma

Prodrug approach is a promising way of overcoming gastrotoxicity associated with long term oral use of NSAIDs like ibuprofen. The candidature of benzyl ester prodrug of ibuprofen was examined to assess its ability to reduce gastrotoxicity without affecting pharmacological response. It gave highly promising activity profile in established animal models like carrageenan induced rat paw oedema and acetic acid induced writhing reflex assay. The effect of physicochemical properties like aqueous solubility, octanol-water partition coefficient, hydrolysis kinetics in human plasma and simulated gastric fluid, on activity profile has been investigated.

Ibuprofen

Carrageenan

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Citations (2)

Enhanced Neurobehavioral Effects of Jadwar (Delphinium denudatum) Aqueous Fraction by Applying Nanotechnology Based Approach

Journal of Neurology & Neurophysiology (2015)

Syed Mohd Abbas Zaidi Shadab A. Pathan Shahid Jamil Farhan Jalees Ahmad Roop K. Khar

Delphinium denudatum Wall. (Ranunculaceae) is an indigenous medicinal herb popularly known as ‘Jadwar ’widely used in traditional Unani system of medicine for the treatment of a variety of human ailments including epilepsy. In order to increase the bioavailability, the nanophytosome of the Delphinium denudatum root aqueous fraction (DNP) was prepared, characterized and evaluated.

Delphinium

Ranunculaceae

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Citations (2)

Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery

Nanomedicine Nanotechnology Biology and Medicine (2009)

Himanshu Gupta Mohd. Aqil Roop K. Khar Asgar Ali Aseem Bhatnagar

Zeta potential

Sparfloxacin

Penetration (warfare)

PLGA

10.1016/j.nano.2009.10.004

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Citations (342)

Phytosomes:A Brief overview

Journal of Pharmaceutical Research (2016)

Sarika Dhir Roop K. Khar G. S. Chakraborthy Maan Saurabh

Phytoconstituents have been used in medicine since ancient times due to their various pharmacological actions. Inspite having excellent bio-activity of plant extract and their phytoconstituents in vitro they have no in vivo actions due to their poor lipid solubility or inappropriate molecular size or both, which results in their poor absorption andlower bioavailability. Phytosomes are the novel formulation technology which helps to overcome these problems.Phytosomes are produced by a process whereby a standardized plant extract or its constituents are bound to phospholipids; mainly phosphotidylcholine, producing a lipid compatible complex. The phytosome technology has been applied over many popular herbal drugs such as Ginko biloba, hawthorn, olive oil, grape seed, green tea and ginseng. This article reviews the recent trends in phytosomes drug delivery.

10.18579/jpcrkc/2016/15/2/94471

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Citations (19)

Novel Polymer Coupled Lipid Nanoparticle of Paclitaxel with Synergistic Enhanced Efficacy Against Cancer

Journal of Biomedical Nanotechnology (2011)

Deepak Singodia Sushama Talegaonkar Roop K. Khar Prabhat Ranjan Mishra

This study was aimed to develop chitosan coupled lipid nanoparticle (Ch-Ptx-Lip), where immunomodulatory activity of chitosan and chemotherapeutic effect of paclitaxel can synergistically enhance efficacy of this novel drug delivery system. Particle size, zeta potential and % Entrapment Efficiency (%EE) of Ch-Ptx-Lip was found to be 113.3 +/- 4.5 nm (PDI: 0.38), (+)35.7 +/- 2.9 mV and 96.4 +/- 1.8% respectively. Morphological evaluation of these particles by TEM shows circular bilayer structure along with outer polymer layers. Ch-Ptx-Lip showed significantly enhanced cytotoxicity (p < 0.05) compared with marketed formulation (Ptx Solution) and Ptx-Lip when evaluated in-vitro by MTT assay on MCF-7 cell lines. Improved efficacy with lower dose of drug can be a new strategy against cancer with minimum side effects and shorter treatment duration.

Zeta potential

MTT assay

Dispersity

10.1166/jbn.2011.1233

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Citations (7)

Biotechnology and intellectual property

Scientific Research and Essays (2006)

Saima Amin Daneshyar Kanchan Kohli Roop K. Khar

Through out the decades, biotechnology has emerged as research area which requires the understanding of the biological intricacies of nature. Much of the scientific knowledge has been imparted to transfer beneficial genetic traits from one species to another to enhance or protect an organism. In the field of medicine, these tasks have ranged from the production of proteins, such as insulin, to selective targeting and binding of specific cell types. Since the discovery in the year 1800 that the human body is composed of cells and proteins that are susceptible to infection but can also combat pathogenic microbes, the perceived battlefield has challenged our imagination to develop biopharmaceuticals – biologically based therapeutic products . As we enter the information age, the presence of excessive amount of biologic and genetic data, coupled with exponential growth in computing power, mean that the rate of developing novel biopharmaceuticals is not at all limited by the ability to identify targets and clone macromolecules. But after post GATT period, this research area has faced a lot of restrictions by the government to follow the patent protection of these biologically engineered products of plant or human cell origin. Thus, biotechnology which is usually defined as any technique that uses living organisms or substances from organisms to make or modify a product, to improve plants or animals or to develop microorganisms for specific uses, is facing serious constraints like lack of skilled human resources, funds to bear the cost of these projects, the sophisticated infrastructure and facilities and stringent government laws. Key words: Biotechnology, patents, biomodulation, tissue.

Battlefield

10.5897/sre.9000243

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Citations (8)

Stability‐indicating ultra‐performance liquid chromatography method for the estimation of thymoquinone and its application in biopharmaceutical studies

Biomedical Chromatography (2010)

Shadab A. Pathan Gaurav Jain Syed Mohd Abbas Zaidi Sohail Akhter Divya Vohora

Abstract Thymoquinone (THQ) is known for its neuroprotective and anti‐convulsant properties in preclinical studies. We herewith describe a simple, rapid, selective, sensitive and stability‐indicating UPLC method for the estimation of THQ and its application to biopharmaceutical studies such as in vitro release from nanoparticulate system and in vivo pharmacokinetic study. The method employed gradient elution using a Waters Acquity HSS‐T3 C 18 (100 × 2.1 mm, 1.8 µm) UPLC column. The mobile phase consisted of water and acetonitrile, pumped at a flow rate of 0.5 mL/min. The injection volume was 5 µL and THQ was monitored at 294 nm wavelength with a total run time of 6 min. In solution as well as in plasma, the method was found to be linear ( r ≥ 0.998), precise (CV ≤ 2.45%) and accurate (recovery ≥ 84.8%) in the selected concentration range of 0.1–0.8 µg/mL. Forced degradation studies revealed that THQ undergoes degradation under acidic, basic, oxidation and UV light stress conditions. However, the developed UPLC method could effectively resolve degradation product peaks from THQ. Further, no interference was found at the retention time of THQ from any plasma components, indicating selectivity of the developed method. For solutions, the limits of detection and quantitation of the method were found to be 0.001 and 0.0033 µg/mL, respectively; while in plasma they were 0.006 and 0.02 µg/mL, respectively. The validated method was successfully applied to quantify THQ in dissolution medium as well as oral in vivo pharmacokinetic study of THQ suspension and THQ‐ solid lipid nanoparticle (THQ‐SLN) formulation. A 2‐fold increase in the relative bioavailability was observed with the THQ‐SLN compared with THQ. The results indicate that the SLN significantly increased plasma concentrations and retention within the systemic circulation. Copyright © 2010 John Wiley & Sons, Ltd.

Thymoquinone

10.1002/bmc.1492

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Citations (54)