Leony Cristina Caetano

Universidade de São Paulo

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José Clóvis do Prado Júnior

Universidade de São Paulo

Míriam Paula Alonso Toldo

Universidade de São Paulo

Marina Del Vecchio Filipin

Universidade de São Paulo

Vânia Brazão

Universidade de São Paulo

Fabrícia Helena Santello

Universidade de Ribeirão Preto

Luana Naiara Caetano

Universidade de São Paulo

Eduardo Osório Frare

Instituto Butantan

Jerri C. Caldeira

University of New Mexico

Carla Domingues Santos

Universidade de São Paulo

Ana Amélia Carraro Abrahão

Universidade de São Paulo

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Universidade de São Paulo

Universidade de Ribeirão Preto

Instituto de Ciências Farmacêuticas

Universidade Brasil

SUPERA Park of Innovation and Technology of Ribeirão Preto

Instituto Adolfo Lutz

Instituto Dante Pazzanese de Cardiologia

Universidade de Franca

Universidad San Pedro

Hospital Universitário da Universidade de São Paulo

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BIO080 Oral melatonin administration and sexual hormones influences during the experimental chagas’ disease

Revista Eletrônica de Farmácia (2012)

Fabrícia Helena Santello Leony Cristina Caetano Marina Del Vecchio Filipin Vânia Brazão Míriam Paula Alonso Toldo

Chagas’disease is the clinical manifestation of the infection produced by the parasite Trypanosoma cruzi. It’s a zoonosis and the major cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are largely inadequate. Melatonin is an indoleamine synthesized in the pineal gland and its physiological properties are not limited to neuroendocrine system in controlling circadian rhythms, several other actions have been discovered as increase innate and acquired immunity, however, very little is known about its influence on protozoan infections. Gender affects the different steps of an immune response. Exposure to various types of antigens, access to health promotion programs and health care, as well as prioritization of health needs and household resource allocation all affect the different response of females and males to immunologic challenges and it is necessary undertand the influences of immunological mechanisms in health and disease.

Chagas Disease

10.5216/ref.v9i1.21930

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Orchiectomy and melatonin therapy in Trypanosoma cruzi infected rats

Resumos (2010)

Fabrícia Helena Santello Vânia Brazão Marina Del Vecchio Filipin Leony Cristina Caetano Míriam Paula Alonso Toldo

Orchiectomy

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Experimental Chagas’ disease in orchiectomized Calomys callosus infected with the CM strain of Trypanosoma cruzi

Experimental Parasitology (2009)

Ana Cláudia Henriques Pinto Leony Cristina Caetano Antônio Marcos A. Levy Renata D’Ambrósio Fernandes Carla Domingues Santos

The incidence and progression of disorders associated with an unbalanced immune response has among many factors the gender as a contributory factor. The aims of this work were to evaluate the effects of orchiectomy and the immune response during the experimental Trypanosoma cruzi infection. Young adult, male Calomys callous were i.p. inoculated with 1 x 10(5) blood trypomastigotes of the CM strain of T. cruzi and divided in groups: Control, Sham and Castrated. Castrated group displayed significantly lower values for prostate and seminal vesicle weights indicating a drastic drop of testosterone plasmatic levels. Orchiectomized animals also displayed lesser number of blood parasites, enhanced lytic antibody percentage, splenocyte proliferation and NO concentration when compared to its sham and control counterparts, indicating that steroid gonadal ablation actually influences immune response triggering a more efficient cellular and humoral response which led animals to become more resistant against T. cruzi infection.

Chagas Disease

Orchiectomy

10.1016/j.exppara.2009.08.005

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Trypanosoma cruzi: The effects of zinc supplementation during experimental infection

Experimental Parasitology (2007)

Vânia Brazão Marina Del Vecchio Filipin Leony Cristina Caetano Míriam Paula Alonso Toldo Luana Naiara Caetano

Chagas Disease

10.1016/j.exppara.2007.11.008

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Citations (20)