E.V. Tsianos

University of Ioannina

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Dimitrios Christodoulou

University Hospital of Ioannina

Moses Elisaf

Aristotle University of Thessaloniki

GΝ

George Ν. Dalekos

University of Thessaly

ΓΠ

Γεώργιος Παππάς

University of Ioannina

Georgios Kalambokis

University of Ioannina

Dimitrios E. Sigounas

Edinburgh Royal Infirmary

Leonidas Christou

University of Ioannina

Nikolaos Akritidis

General Hospital of Ioannina G. Hatzikosta

Eleftheria Zervou

University Hospital of Ioannina

K. C. Siamopoulos

University of Ioannina

Cooperative Institutions

University of Ioannina

117

University Hospital of Ioannina

National and Kapodistrian University of Athens

University College London

General Hospital of Ioannina G. Hatzikosta

Aristotle University of Thessaloniki

The Royal Free Hospital

University of Thessaly

University Gastroenterology

University of Patras

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Treatment of brucella spondylitis: lessons from an impossible meta-analysis and initial report of efficacy of a fluoroquinolone-containing regimen

International Journal of Antimicrobial Agents (2004)

Γεώργιος Παππάς Savvas Seitaridis Nikolaos Akritidis E.V. Tsianos

Spondylitis

Regimen

10.1016/j.ijantimicag.2004.05.003

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Citations (63)

Infectious Diseases in Cinema: Virus Hunters and Killer Microbes

Clinical Infectious Diseases (2003)

Γεώργιος Παππάς Savvas Seitaridis Nikolaos Akritidis E.V. Tsianos

The world of infectious diseases has been rarely presented in the cinema with accuracy. Apart from random biographies of scientists and retellings of stories about great epidemics from the past, most films focus on the dangers presented by outbreaks of unknown agents that originate from acts of bioterrorism, from laboratory accidents, or even from space. We review these films and underline the possible effect that they have on the public's perception of infection--a perception that, when misguided, could prove to be problematic in times of epidemics.

10.1086/377740

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Citations (45)

High frequency of antibodies to Hantaan virus and hepatitis C virus in chronic haemodialysis patients Coincidence or cross‐reaction?

Journal of Internal Medicine (1993)

E.V. Tsianos G. N. Dalekos Moses Elisaf Eleftheria Zervou Kostas C. Siamopoulos

Abstract. Objectives. To address the question of whether there is any coincidence or cross‐reaction between hepatitis C virus (HCV) and Hantaan virus (both RNA arboviruses), as well as to assess the frequency of antibodies to the above viruses amongst chronic haemodialysis patients in our region. Design. Collection of serum samples from consecutive unselected chronic haemodialysis patients. Setting. A tertiary referral center (University Hospital). Subjects. One hundred and fourteen chronic haemodialysis patients were investigated for the presence of antibodies to HCV (anti‐HCV) and Hantaan virus disease (anti‐HVD). Eleven unselected non‐haemodialysis patients with well‐defined haemorrhagic fever with renal syndrome (HFRS) were also investigated for the anti‐HCV antibodies comprising the disease control group. Interventions. None. Main outcome measures. The utility of an anti‐HVD positive test in chronic haemodialysis patients. Results. Seventeen patients (14.9% 95% confidence interval [CI] 8.4–21.4%) were anti‐HCV positive, whereas 15 (13.2%, 95% CI 6.9–19.3%) were anti‐HVD positive. An anti‐HCV positive test was confirmed by recombinant immunoblot assay (RIBA II) in 88.2%. The presence of anti‐HCV antibodies was not associated with transfusions but with the longer duration of haemodialysis (62.8 ± 29.8 vs. 31.2 ± 29.3 months, P < 0.001). Anti‐HVD antibodies were not associated with transfusions or with the duration of haemodialysis. Three patients were positive for both anti‐HCV and anti‐HVD antibodies. None of the 11 patients with well‐defined HFRS had anti‐HCV antibodies. Conclusions. Chronic haemodialysis patients are a high risk group for HCV infection in association with the duration of haemodialysis and, at least for our geographical area, these patients have to be examined for anti‐HVD antibodies especially when a definite causative agent for chronic renal failure is not found. The HVD and HCV infection are not exceptional amongst haemodialysis patients in our region, whereas the possibility of a cross‐reaction between these two RNA arboviruses is rather excluded as there was no evidence of HCV infection amongst the patients with well‐defined HFRS.

10.1111/j.1365-2796.1993.tb01021.x

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Citations (13)

Multiple brown tumors of the ribs simulating malignancy

Journal of Endocrinological Investigation (2005)

Georgios Kalambokis G. Economou Sevasti Kamina Dionysios J. Papachristou M Bai

10.1007/bf03347558

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Red face, postendoscopy

BMJ Case Reports (2011)

Leonidas Christou Vasilios Saugos Ioannis Vagias E.V. Tsianos

The authors present a case report of extensive facial petechiae following esophagogastroduodenoscopy (EGD). The patient was a previously healthy male who did not receive any medication predisposing to haemorrhage, nor did he suffer from any underlying disorder (as the subsequent diagnostic work-up demonstrated) that predisposed to the extensive facial capillary rupture. Increased intrathoracic pressure during EGD can rarely result in similar cases that are alarming to the patient and possibly the endoscopy staff, and awareness of their potential and their benign nature and prognosis can assist in reassuring patients.

Esophagogastroduodenoscopy

Work-up

10.1136/bcr.09.2010.3375

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Bcl-2 expression in colorectal tumours. Correlation with p53, mdm-2, Rb proteins and proliferation indices.

PubMed (2000)

A. Goussia E. Ioachim N J Agnantis M. Mahera E.V. Tsianos

Immunostaining for bcl-2 protein was performed in 27 colorectal adenomas and 108 colorectal adenocarcinomas. The aim of the study was to determine bcl-2 expression in correlation with p53, mdm-2 and Rb expression, with proliferation indices (Ki-67-LI, PCNA-LI) as well as with conventional clinicopathological variables. A higher proportion of adenomas (30.8%) than carcinomas (16.7%) expressed bcl-2 and conversely, a lower proportion of adenomas (7.4%) than carcinomas expressed p53 (57.1%), the difference being statistically significant (p<0.0001). No correlation of bcl-2 expression with p53 expression (parallel or inverse) as well as with the other parameters studied was observed in any tumour. The bcl-2+/p53- subgroup of cancers showed a trend for correlation with negative lymph node status. Our data suggest, that bcl-2 expression may be involved in the early phase of colorectal carcinogenesis regardless of p53 status, while p53 function may be involved in a late stage of the adenoma-carcinoma sequence. P53 is apparently not involved in the regulation of apoptosis in the colorectal neoplasias or perhaps bcl-2 expression, as an early event in colorectal tumours, may occur before changes of p53 take place. Tumours with bcl-2+/p53- immunophenotype are frequently associated with negative lymph node status and seem to have a less aggressive behavior.

Immunostaining

P53 expression

10.14670/hh-15.667

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Citations (13)

Outbreak of haemorrhagic fever with renal syndrome in Greece

European Journal of Clinical Microbiology (1985)

Kostas C. Siamopoulos Άθως Αντωνιάδης Nicholas C. Acritidis Stavros H. Constantopoulos E.V. Tsianos

Hantaan virus

Antibody titer

10.1007/bf02013578

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Akinetic mutism followed by a manic reaction on introduction of steroid replacement for Addison’s disease

Journal of Endocrinological Investigation (2006)

Georgios Kalambokis Spyridon Konitsiotis Dimitrios A. Pappas E.V. Tsianos

Addison Disease

10.1007/bf03345550

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Citations (6)

The immunohistochemical expression of metallothionein in inflammatory bowel disease. Correlation with HLA-DR antigen expression, lymphocyte subpopulations and proliferation-associated indices.

PubMed (2003)

E. Ioachim M. Michael Christos S. Katsanos A Demou E.V. Tsianos

Metallothionein (MT) expression in intestinal resection specimens from 41 patients with ulcerative colitis (UC) and 10 patients with Crohn's disease (CD ) was immunohistochemically studied by the avidin-biotin (ABC) method. In addition, the possible relationship of its expression with HLA-DR antigen expression, lymphocyte subpopulations and proliferation-associated indices was studied in order to elucidate the role of this molecule in inflammatory bowel disease (IBD). The MT immunoreactivity was recorded by staining and intensity-distribution scores. MT staining varied in and was mainly localized in the cytoplasm, although a combined nuclear/cytoplasmic reactive pattern was also seen in epithelial cells. MT expression was decreased in UC, and CD compared with normal mucosa. No difference in MT expression between UC and CD was noted. In UC, a gradually decreased expression from remission, to resolving and to active phase was observed. An inverse correlation of MT expression with HLA-DR antigen expression was detected (p = 0.018) in the cases of UC. The data suggest that a low level of MT expression in inflammatory bowel disease and particularly in active phase of UC may indicate a decreased endogenous intestinal protection and it may be implicated in the pathogenesis of the disease.

Pathogenesis

Metallothionein

10.14670/hh-18.75

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Citations (15)

PULMONARY AND GASTROINTESTINAL MANIFESTATIONS OF SJÖGREN’S SYNDROME

Rheumatic Disease Clinics of North America (1992)

Stavros H. Constantopoulos E.V. Tsianos H M Moutsopoulos

10.1016/s0889-857x(21)00320-3

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Citations (66)