Ferruccio Fazio

Ospedale Garibaldi

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i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Maria Carla Gilardi

University of Milano-Bicocca

Giovanni Lucignani

University of Milan

Daniela Perani

Vita-Salute San Raffaele University

Claudio Landoni

Azienda Ospedaliera San Gerardo

Rosa Maria Moresco

University of Milano-Bicocca

Giovanna Rizzo

Tecnologie Avanzate (Italy)

Valentino Bettinardi

IRCCS Ospedale San Raffaele

Maria Picchio

Vita-Salute San Raffaele University

Mario Matarrese

Institute of Molecular Bioimaging and Physiology

C. Messa

University of Milano-Bicocca

Cooperative Institutions

Istituti di Ricovero e Cura a Carattere Scientifico

475

University of Milan

426

Vita-Salute San Raffaele University

374

San Raffaele University of Rome

363

IRCCS Ospedale San Raffaele

236

Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele

225

University of Milano-Bicocca

181

Institute of Molecular Bioimaging and Physiology

Ospedale Maggiore

University of Pavia

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Papers

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Research Field

A Model-Based Deconvolution Approach to Solve Fiber Crossing in Diffusion-Weighted MR Imaging

IEEE Transactions on Biomedical Engineering (2007)

Flavio Dell’Acqua Giovanna Rizzo Paola Scifo Rafael Alonso Clarke Giuseppe Scotti

A deconvolution approach is presented to solve fiber crossing in diffusion magnetic resonance imaging. In order to provide a direct physical interpretation of the signal generation process, we started from the classical multicompartment model and rewrote this in terms of a convolution process, identifying a significant scalar parameter alpha to characterize the physical system response. Deconvolution is performed by a modified version of the Richardson-Lucy algorithm. Simulations show the ability of this method to correctly separate fiber crossing, even in the presence of noisy data, with lower signal-to-noise ratio, and imprecision in the impulse response function imposed during deconvolution. The in vivo data confirms the efficacy of this method to resolve fiber crossing in real complex brain structures. These results suggest the usefulness of our approach in fiber tracking or connectivity studies

Impulse response

Convolution (computer science)

SIGNAL (programming language)

10.1109/tbme.2006.888830

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Citations (196)

Different Brain Correlates for Watching Real and Virtual Hand Actions

NeuroImage (2001)

Daniela Perani Ferruccio Fazio N. Alberto Borghese Marco Tettamanti Stefano Ferrari

10.1006/nimg.2001.0872

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Citations (288)

SCINTIGRAPHIC DETERMINATION OF REGIONAL LUNG PERFUSION.

C. Giuntini Ferruccio Fazio A. Santolicandro R. Navalesi

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Citations (0)

Multifocal, Persistent Cardiac Uptake of [18-F]-Fluoro-Deoxy-Glucose Detected by Positron Emission Tomography in Patients With Acute Myocardial Infarction

Circulation Journal (2008)

Cosmo Godino Cristina Messa Luigi Gianolli Claudio Landoni Alberto Margonato

Background Inflammation appears to be important in the pathogenesis of acute myocardial infarction (AMI). Methods and Results Cardiac [18-F]-fluoro-deoxy-glucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT)-scan was investigated in 12 fasting patients with first AMI (FAMI) single-vessel disease after successful primary percutaneous coronary intervention and at 9 weeks follow-up, and in 12 controls. The average FDG uptake (aFDGu) of the 28 left ventricular (LV) wall segments defined on the PET/CT images of the 12 FAMI patients was 1.28±0.57-fold higher than the activity present in the LV cavity. By contrast, the aFDGu of the 12 controls was 0.70±22 (p<0.001). The segmental aFDGu in the FAMI was multifocal in both the culprit and non-culprit segments; it was less than LV cavity activity in 38%, 1-2-fold greater in 51.8% and more than 2-fold greater in 10.2%. At follow-up, aFDGu was significantly increased in both culprit and non-culprit segments (1.69±1.15, p<0.001). Statistically significant differences between FAMI and controls patients were only found for interleukin-6 plasma levels on admission (11.3±7.7 pg/ml vs 2.2±1.3 pg/ml; p<0.004). Conclusion Multifocal, non-infarct related, cardiac-FDG-uptake occurred immediately after AMI and persisted at follow-up. The cause of these striking and consistent findings is still speculative. (Circ J 2008; 72: 1821 - 1828)

Culprit

10.1253/circj.cj-08-0046

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Citations (7)

Role of 18FDG-PET/CT in detecting relapse during follow-up of patients with Hodgkin’s lymphoma

Annals of Hematology (2009)

Roberto Crocchiolo Federico Fallanca Giampiero Giovacchini Andrés J.M. Ferreri Andrea Assanelli

Hematology

Fluorodeoxyglucose

PET-CT

10.1007/s00277-009-0752-4

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Citations (38)

Ruolo della tomografia ad emissione di positroni nella caratterizzazione dei noduli solitari polmonari indeterminati

Minerva Pneumologica (2002)

E. Pelosi Maria Picchio Claudio Landoni Luigi Gianolli Angelina Cistaro

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Biodistribution in tumour-bearing mice of two 90Y-labelled biotins using three-step tumour targeting

Nuclear Medicine Communications (1997)

Marco Chinol Giovanni Paganelli F. Sudati Claude F. Meares Ferruccio Fazio

Tumour pretargeting techniques based on a three-step approach with the avidin/biotin system and associated with the high-energy beta-emitter yttrium-90 (90Y) have been applied with encouraging results in cancer therapy. While in-vivo stable binding of 90Y through a chelating agent like DOTA is essential for directly labelled monoclonal antibodies in the labelling of a fast clearing molecule like biotin, this may not be so important, since the time for catabolic processes to occur is drastically reduced. In this study, the biodistribution of 90Y bound to biotin through DTPA or DOTA was evaluated. Tumour-bearing mice received biotinylated antibody on day 1, avidin on day 2 and 90Y-labelled biotin on day 3. The biodistribution was determined 4 and 24 h after the injection of radiolabelled biotin. The majority of the injected dose was recovered in the urine 4 h after injection of both radiolabelled compounds. Higher bone uptake of 90Y was observed in animals administered 90Y-DTPA-biotin. In general, all organs including tumour showed higher accumulation of activity following the injection of 90Y-DTPA-biotin. Despite the lower levels of accumulation in the tumour after injection of 90Y-DOTA-biotin, the tumour-to-liver and tumour-to-bone ratios for the DOTA ligand were higher compared to DTPA. The higher rumour uptake observed after injection of 90Y-DTPA-biotin may be attributed to the presence of two biotin molecules in its dimeric structure. Our results indicate that the ideal 90Y-labelled biotin derivative for therapy studies should be formed from a DOTA core with two non-cleavable spacers, each ending with a biotin molecule.

Pretargeting

Biodistribution

DOTA

Avidin

Conjugate

Immunoscintigraphy

10.1097/00006231-199702000-00014

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Citations (22)

PET/CT in diagnostic oncology.

PubMed (2004)

C. Messa Valentino Bettinardi Maria Picchio Ettore Pelosi Claudio Landoni

In the last years positron emission tomography (PET) with 18F-fluorodeoxyglucose ([18F]FDG) has become an established technique for the staging and follow-up of a wide variety of neoplasms. As PET imaging is based on the physiological mediated distribution of the administered tracer, rather than on anatomic and structural characteristics of tissue, the addition of CT imaging to PET improves the interpretation of PET images. Recently, integrated PET/CT scanners have been developed that can produce directly functional PET and anatomical CT data 1 session, without moving the patient and with minimal delay between the reconstruction and fusion of the 2 image data sets. In addition, CT images are also being used for attenuation correction in the reconstruction process of the PET emission data. A brief review of the most relevant technical characteristics of 3 PET/CT systems, which represent the state of the art of this technology, are described. Furthermore an overview of PET/CT acquisition protocols and clinical applications of PET/CT in oncology are described. Overall, advantages of PET/CT over PET that may influence the clinical routine, have been identified as a) the shorter image acquisition time with benefit on patients throughput and on patient compliance, b) the better accuracy in anatomically localizing focal areas of abnormal tracer uptake and defining tumor extent and c) the possibility to stage a disease in 1 single step.

PET-CT

Correction for attenuation

Fluorodeoxyglucose

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Citations (46)

Author Index Vol. 83, 2005

Stereotactic and Functional Neurosurgery (2005)

Yoshimasa Mori Tatsuya Kobayashi Yoshihisa Kida Kyota Oda Yuta Shibamoto

10.1159/000092620

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Citations (0)