Choong-Hwan Lee

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Enzymatic Synthesis of Phenolic CoAs Using 4-Coumarate:coenzyme A Ligase (4CL) from Rice

Bulletin of the Korean Chemical Society (2007)

Yoon-Jung Lee Youngmin Jeon Jong Suk Lee Bong-Gyu Kim Choong-Hwan Lee

The enzyme, 4-coumarate:CoA ligase (4CL) catalyzes theconversion of 4-coumaric acid into coumaroyl-CoA and afew related substrates into their corresponding products suchas cinnamoyl-CoA, caffeoyl-CoA, and feruloyl-CoA in a pro-cess utilizing ATP and thus channels the common, phenyl-alanine-derived building block into the widely distinct branchesof general phenylpropanoid metabolism.

Coenzyme A

10.5012/bkcs.2007.28.3.365

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Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

Journal of Materials Chemistry (2007)

Jaemoon Yang Choong-Hwan Lee Joseph Park Sungbaek Seo Eun‐Kyung Lim

DOX–magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.

PLGA

10.1039/b702538f

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Citations (187)