Solo Kuvibidila

Louisiana State University Health Sciences Center New Orleans

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Lolie C. Yu

Louisiana State University Health Sciences Center New Orleans

Brenda J. Smith

Oklahoma State University Oklahoma City

David Ode

Louisiana State University Health Sciences Center New Orleans

Stephen L. Clarke

Oklahoma State University

Edralin A. Lucas

Oklahoma State University

Raj Warrier

Ochsner Medical Center

R. P. Warrier

Canberra Hospital

Renée V. Gardner

Louisiana State University Health Sciences Center New Orleans

María Velez

Louisiana State University Health Sciences Center New Orleans

B. Surendra Baliga

University of South Alabama

Cooperative Institutions

Kyiv City Clinical Oncology Center

274

Chinese Academy of Sciences

Oklahoma State University

University Medical Center New Orleans

Pfizer (United Kingdom)

Louisiana State University Health Sciences Center New Orleans

Tulane University

Louisiana State University

Seascape Consultants (United Kingdom)

Caterpillar (United States)

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970 EFFECT OF DIETARY IRON ON CELLULAR IMMUNE FUNCTION

Pediatric Research (1981)

Robert M. Suskind Solo Kuvibidila B. Surendra Baliga

Weanling

Delayed hypersensitivity

10.1203/00006450-198104001-00995

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Zinc Status But Not Iron Stores Are Inversely Associated With Soluble Vascular Cell Adhesion Molecule‐1 (sVCAM‐1) Levels in Children With Sickle Cell Disease (SCD)

The FASEB Journal (2006)

Solo Kuvibidila Lolie C. Yu María Velez Renee Gardner Raj Warrier

VCAM-1, a protein expressed on endothelial cells, increases the risk of vasooclusion in SCD patients through adhesion of sickle red blood cells. Suboptimal zinc status and iron overload due to blood transfusion have been implicated in disease severity through oxidative stress. However, the influence of these factors on VCAM-1 has not been previously investigated. We measured sVCAM-1, zinc, hemoglobin [Hb], hematocrit [Hct], and serum ferritin in 76 SCD children and 96 non-SCD children, mean age 7.73 y and 11.24 y, respectively. Although mean zinc levels of both groups were within the normal range (≈14.5 μmol/l), 14.5 % of SCD and 11% of non-SCD children had levels below normal (10.7 μmol/L). As expected, mean Hb and Hct of SCD children were below normal and serum ferritin levels were 2–3 fold higher than those usually seen in healthy children. Mean sVCAMs1 levels of SCD children (837 μg/l) were higher than those of controls (627 μg/l) (p <0.0001). Differences persisted after taking into account age, Hb phenotypes, and inflammation (α1-acid glycoprotein >1g/l and C-reactive protein >10 mg/l). sVCAM-1 negatively correlated with serum (r=−0.444) and red blood cells zinc (r=−0.242, p <0.05), but not acute phase proteins. Hb and Hct, but not serum ferritin levels tended to inversely correlate with sVCAM-1 in children with SS and Sβthal Hb phenotypes (r≤−0.3364, p >0.05). Data suggest that zinc, but not body high iron stores may modulate SCD clinical status through VCAM-1 expression, and zinc supplementation may be beneficial in these patients. Funds: Pediatrics

Haptoglobin

10.1096/fasebj.20.4.a629-a

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The influence of tea consumption on iron status and anthropometry in young zairean children

Solo Kuvibidila V Mbele David Ode Rachana Warrier

Consumption

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Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin-2 Secretion by Murine Spleen Cells: Possible Implication on the Immune Function and Risk of Pain Crisis in Patients with Sickle Cell Disease.

PubMed (2015)

Solo Kuvibidila Rajasekharan Warrier Johnson Haynes Surendra Baliga

Hydroxyurea (HU) reduces major complications associated with sickle cell disease in part because of the induction of fetal hemoglobin. However, because of its antiproliferative property, its long-term use may impair immunity. Zileuton, a derivative of HU, also induces fetal hemoglobin and has antiinflammatory properties, a feature that can reduce the risk of sickling. Our goal was to investigate the capacity of both drugs to modulate the secretion of interleukin-2 (IL-2), a regulatory cytokine for immune responses.Spleen cells obtained from 11 4-month-old C57BL/6 female mice were incubated without and with 10 μg/mL HU or zileuton, 2.5 μg/mL concanavalin A (ConA), 20 μg/mL phytohemagglutinin (PHA), and 50 ng/mL anti-CD3 antibody for 12-48 h. IL-2 was measured in the supernatant by enzyme-linked immunosorbent assay and cell proliferation by (3)H-thymidine uptake.While HU reduced lymphocyte proliferation in response to mitogens (P<0.05), zileuton did not. Baseline IL-2 concentration and PHA-induced IL-2 were not significantly affected by either drug. Contrary to what we expected, while HU increased IL-2 supernatant levels 1.17-fold to 6.5-fold in anti-CD3 antibody-treated cells (P<0.05), zileuton decreased them 35%-65% (P<0.05). Zileuton likely reduced IL-2 levels by inhibiting 5-lipoxygenase, hence leukotriene B4 production, an IL-2 inducer. HU did not decrease IL-2 secretion likely because of its lack of effect on mRNA and protein synthesis.Modulation of IL-2 secretion by zileuton and/or reduced lymphocyte proliferation by HU may impair the immune response of patients with sickle cell disease but may also be beneficial by attenuating inflammation independently of fetal hemoglobin induction.

Zileuton

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Nutritional status of children with sickle cell disease

Journal of Pediatric Hematology/Oncology (1991)

Solo Kuvibidila R. P. Warrier Li Yu Leon S. Gordon

10.1097/00043426-199121000-00088

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Differential effects of iron deficiency on the expression of CD80 and CD86 co‐stimulatory receptors in mitogen‐treated and untreated murine spleen cells

Journal of Cellular Biochemistry (2002)

Solo Kuvibidila Connie Porretta

Abstract The interaction of CD28 and its ligands (CD80, CD86) on antigen presenting cells and that of TCR/CD3‐MHC are required for T lymphocyte activation. To determine whether impaired lymphocyte proliferation associated with iron deficiency is due to reduced expression of these ligands, spleen cells obtained from eight to nine C57BL/6 mice/group of iron deficient (ID), iron replete (R), control (C), pair‐fed (PF), and high iron (HI) mice were labeled with anti‐CD80‐fluorescein isothiocyante (FITC) and anti‐CD86‐FITC. Diets differed only in iron concentration: 5, 50, and 125 mg/kg for the ID, C, and HI, respectively. Mean levels of hemoglobin and liver iron stores of ID and R mice were less than 50% those of C mice ( P < 0.005). In non‐activated and concanavalin A‐treated cultures, significant differences were observed among groups in the percentage of CD80 + cells: ID>R > C = PF = HI ( P < 0.05). The same trend was observed for CD86 + cells ( P > 0.05). Fluorescence intensity (FI) of either marker did not significantly change by iron status. In vitro iron chelation by deferoxamine (20, 200 μg/ml) for 1, 2, and 24 h increased FI of both markers on unactivated B and T cells ( P < 0.05). However, it had no effect on FI of either marker of mitogen‐treated cells presumably because the maximum levels are achieved by the mitogen. Lymphocyte proliferative responses to mitogens positively and significantly correlated with CD80 and CD86 FI (r = 0.41−0.59) but negatively correlated with the percentages of CD80 + cells (r = −0.48) ( P < 0.05). Data suggest that impaired lymphocyte proliferation associated with iron deficiency is not due to reduced CD80 and CD86 expression. J. Cell. Biochem. 86: 571–582, 2002. © 2002 Wiley‐Liss, Inc.

CD86

CD80

10.1002/jcb.10206

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Effects of iron deficiency on the secretion of interleukin‐10 by mitogen‐activated and non‐activated murine spleen cells

Journal of Cellular Biochemistry (2003)

Solo Kuvibidila Lolie C. Yu David Ode María Velez Renée V. Gardner

Abstract Interleukin (IL)‐10 plays crucial regulatory roles in immune responses by inhibiting the secretion of several cytokines (IL‐2, IL‐12, interferon‐gamma (IFN‐γ)) and lymphocyte proliferation. Iron deficiency, a public health problem for children, alters these immune responses. To determine whether these changes are related to altered IL‐10 secretion, we measured IL‐10 in 24 and 48 h supernatant of spleen cell cultures from iron deficient (ID), control (C), pairfed (PF), and ID mice fed the control diet (iron repletion) for 3 (R3) and 14 (R14) days (d, n = 12/group). Mean levels of hemoglobin, hematocrit, and liver iron stores varied as follows: C ≈ PF ≈ R14 > R3 > ID ( P < 0.01). Mean baseline IL‐10 levels of ID mice tended to be higher than those of other groups ( P > 0.05, ANOVA). Mean IL‐10 levels secreted by concanavalin A (Con A) and antibody raised against cluster of differentiation molecule 3 (anti‐CD3)‐treated cells (±background) were lower in ID than in C (48 h) and iron replete mice ( P < 0.05). Underfeeding also reduced IL‐10 secretion by anti‐CD3‐treated cells (48 h, P < 0.05). Lymphocyte proliferative responses to anti‐CD3 ± anti‐CD28 antibodies were lower in ID than in C and PF mice, and they were corrected by iron repletion ( P < 0.05). IL‐10 levels negatively correlated with indicators of iron status (r ≤ −0.285) and lymphocyte proliferation (r ≤ −0.379 [r ≤ −0.743 for ID mice]), but positively correlated with IFN‐γ levels (r ≤ 0.47; P < 0.05). Data suggest that iron deficiency has a generalized deleterious effect on cells that secrete both cytokines. Reduced IL‐10 secretion by activated cells does not overcome the inhibition of lymphocyte proliferation due to other factors of T cell activation that are regulated by iron. J. Cell. Biochem. 90: 278–286, 2003. © 2003 Wiley‐Liss, Inc.

10.1002/jcb.10627

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Citations (17)

Index, Volume 21, 2019

International journal of medicinal mushrooms (2019)

Ge Wang Xiumin Zhang Susan Maier Liping Zhang Robert Maier Immunomodulatory

10.1615/intjmedmushrooms.v21.i12.80

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Mango modulates body fat and plasma glucose and lipids in mice fed a high-fat diet

British Journal Of Nutrition (2011)

Edralin A. Lucas Wenjia Li Sandra Peterson Angela L. Brown Solo Kuvibidila

Consumption of fruits and vegetables has been investigated for their role in the prevention of many chronic conditions. Among the fruits, mango provides numerous bioactive compounds such as carotenoids, vitamin C and phenolic compounds, which have been shown to have antioxidant and anti-inflammatory properties. The present study examined the effects of dietary supplementation of freeze-dried mango pulp, in comparison with the hypolipidaemic drug, fenofibrate, and the hypoglycaemic drug, rosiglitazone, in reducing adiposity and alterations in glucose metabolism and lipid profile in mice fed a high-fat (HF) diet. Male C57BL/6J mice were randomly divided into six treatment groups (eight to nine/group): control (10 % energy from fat); HF (60 % energy from fat); HF+1 or 10 % freeze-dried mango (w/w); HF+fenofibrate (500 mg/kg diet); HF+rosiglitazone (50 mg/kg diet). After 8 weeks of treatment, mice receiving the HF diet had a higher percentage body fat ( P = 0·0205) and epididymal fat mass ( P = 0·0037) compared with the other treatment groups. Both doses of freeze-dried mango, similar to fenofibrate and rosiglitazone, prevented the increase in epididymal fat mass and the percentage of body fat. Freeze-dried mango supplementation at the 1 % dose improved glucose tolerance as shown by approximately 35 % lower blood glucose area under the curve compared with the HF group. Moreover, freeze-dried mango lowered insulin resistance, as indicated by the homeostasis model assessment of insulin resistance, to a similar extent as rosiglitazone and modulated NEFA. The present findings demonstrate that incorporation of freeze-dried mango in the diet of mice improved glucose tolerance and lipid profile and reduced adiposity associated with a HF diet.

Rosiglitazone

Fenofibrate

NEFA

10.1017/s0007114511002066

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Citations (46)

Plasma zinc levels inversely correlate with vascular cell adhesion molecule-1 concentration in children with sickle cell disease.

PubMed (2006)

Solo Kuvibidila Manuel Sandoval Juan Lao María Velez Lolie C. Yu

Pathophysiology

Acute chest syndrome

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Citations (18)