J Quero

Universidad Autónoma de Madrid

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Fernando Cabañas

Hospital Universitario Quirónsalud Madrid

Alfredo García‐Alix

Hospital Sant Joan de Déu Barcelona

Adelina Pellicer

Hospital Universitario La Paz

Susana Ares Segura

Hospital Universitario La Paz

Miguel Sáenz de Pipaón

Hospital Universitario La Paz

Rosário Madero

Hospital Universitario La Paz

Sofía P. Salas

Universidad del Desarrollo

Ana Martı́n-Ancel

Hospital Sant Joan de Déu Barcelona

Miriam Martínez-Biarge

Imperial College Healthcare NHS Trust

F Omeñaca

Hospital Universitario La Paz

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Hospital Universitario La Paz

108

Universidad Autónoma de Madrid

Hospital Materno-Infantil

University of Oslo

Oslo University Hospital

Hospital La Paz Institute for Health Research

Instituto de Salud Carlos III

Boston Children's Hospital

Hospital Sant Joan de Déu Barcelona

Research Institute Hospital 12 de Octubre

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ACUTE EFFECTS OF LEVOSIMENDAN ON CEREBRAL AND SYSTEMIC HEMODYNAMICS IN THE NEONATAL PERIOD

Archives of Disease in Childhood (2008)

María Carmen Bravo Paloma López Ortego Alejandra Pesca Barrios Fernando Cabañas J. Pérez Rodríguez

Cardiovascular drugs play a major role in pre-, and postoperative care in neonates with congenital heart disease (CHD), however systematic aproach to the hemodynamic effects of these therapies in the neonatal population is scarce. Management strategies aim to optimize contractility, improve diastolic function, maintain adequate preload, and reduce afterload. Thus, inodilators are standard treatment in these patients. Levosimendan, a novel inodilator, enhances myocardial contractility mainly through myofilament calcium sensitization, and causes peripheral and coronary vasodilation via opening ATP-dependent K-channels in vascular smooth muscle cells. Aims Systematic approach to evaluate the acute hemodynamic effects of levosimendan in neonates with CHD treated for low cardiac output syndrome (LCOS). Methods Observational study. Intervention: 48 hours continuous i.v. levosimendan (0.1–0.2 microg/k/min) infusion. Outcomes: continuous monitoring of mean blood pressure (MBP), heart rate (HR), central and peripheral temperature, transcutaneous CO2. Two near-infrared units (frontal-parietal = C; thigh = P) were used to assess changes in cerebral blood volume, cerebral (C-dDHb) and peripheral (P-dDHb) blood flow, and C and P tissue oxygenation index. Baseline and end-of-study pH and lactate were determined. Results 7 dosis of levosimendan were investigated. Mean study time was 13.3 (7–19) hours. Levosimendan produced an increase in blood flow (C-dDHb, p Conclusions Levosimendan improves cerebral and systemic perfusion in neonates with LCOS.

Levosimendan

Preload

Afterload

Contractility

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Congenital cutaneous candidiasis: Report of four cases and review of the literature

European Journal of Pediatrics (1991)

L. Almeida Santos José Beceiro R. Calvo Hernández Sofía P. Salas Rosa Escribá

Hepatosplenomegaly

10.1007/bf01955935

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Citations (33)

397 Oral Iodine Supplementation and Thyroid Function in Premature Babies Born Less Than 1500 Gr of Weight

Pediatric Research (2010)

Susana Ares Segura Juan Arnáez Sara Santa-Cruz Calvo J Quero Morreale G De Escobar

10.1203/00006450-201011001-00397

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Title: Beta2-Microglobulin (B2M) Concentrations in Cerebrospinal Fluid (CSF) Correlate with Neurodevelopmental Outcome in Newborns with Symptomatic Congenital Cytomegalovirus Infection (SCCI)

Pediatric Research (2011)

Ana Alarcón Miriam Martínez-Biarge Ángel Hernánz J Quero Alfredo García‐Alix

10.1038/pr.2011.369

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Neural migration disorders studied by cerebral ultrasound and colour Doppler flow imaging.

Archives of Disease in Childhood Fetal & Neonatal (1995)

Adelina Pellicer Fernando Cabañas Antonio Përez‐Higueras Alfredo García‐Alix J Quero

Cerebral ultrasound and colour Doppler flow imaging (CDFI) were used to diagnose a wide spectrum of anomalies of cell migration (17 patients): presumed lissencephaly (n = 12); schizencephaly of both fused (n = 2) and open lips (n = 2); hemimegalencephaly (n = 1); and subependymal type grey matter heterotopia (n = 12). The patients with grey matter heterotopia had irregular ventricular margins (n = 10), periventricular hyperechogenic bands (n = 12), and/or periventricular hyperechogenic nodules (n = 7). Some patients had more than one type of migration disorder as well as other central nervous system malformations. Cerebral ultrasound diagnoses were confirmed by magnetic resonance imaging (MRI) or necropsy. It is concluded that colour Doppler flow imaging is a worthwhile addition to the assessment of brain surface anomalies.

Schizencephaly

Polymicrogyria

Hemimegalencephaly

Heterotopia

Subependymal zone

Grey matter

10.1136/fn.73.2.f55

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Citations (27)

How often is extracorporeal membrane oxygenation needed in cases of congenital diaphragmatic hernia?

Pediatric Surgery International (1996)

C Soto Beauregard J Murcia Luis Lassaletta Sofía P. Salas J Quero

Oxygenation index

High-frequency ventilation

10.1007/bf00626058

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[Hypodense nodular images in the spleen of a patient with human immunodeficiency virus infection].

PubMed (1997)

José Luís Callejas Rubio Marı́a Ruz P. Garcia Ruiz J Quero

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Effects of Dexamethasone on Retinal and Choroidal Blood Flow during Normoxia and Hyperoxia in Newborn Piglets

Pediatric Research (1996)

Tom Stiris Dora B. Heras Rosa Codoceo D Lasa C. Suguihara

Hyperoxia

10.1203/00006450-199610000-00013

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Citations (5)

AN OVERVIEW OF PERITONEAL DIALYSIS MANAGEMENT IN NEWBORNS DURING A PERIOD OF 10 YEARS

Archives of Disease in Childhood (2008)

Laura Sánchez Marta Cabrera A M Sanchez-Torres Dolores Elorza J. M. Perez

Introduction The incidence of acute renal failure (ARF) in neonates ranges from 8 to 24%. Peritoneal dialysis (PD) is a replacement therapy used in the neonatal intensive care unit (NICU) in some cases of ARF. Objectives To assess indications, methodology and most important complications of PD in newborns. Materials and Methods Review of medical charts of 39 dialysed newborns, between 1997 and 2007 admitted to a NICU with cardiac surgery. Results 85% were neonates with cardiac diseases, 5% with inborn errors of metabolism, 10% with other aetiologies. Gestational age and weight ranged from 24 to 36.5 weeks and 700 to 2520 g. Dialysis catheter (Arrow 8F) was inserted at the bedside by the neonatology staff, without complications. Initial mean volume hourly amounts were 15 ml/kg of 1.5% glucose dialysate. Increases in volume, mean 19 ml/kg (10–38 ml/kg) and glucose concentration, mean 3.1% were used to get the objectives. Higher ultrafiltrate volume was 6 ml/kg per hour. Indications for PD in congenital heart diseases were: 67% severe oliguria, 16% anuria, 13% hypervolaemia and 6% others. PD was stated at 14 h after surgery bypass and mean duration was 4 days (0.5–23 days). Complications appeared in 20/34 and were: 50% obstruction, 23% fluid loss, 15% hyperglycaemia, 8% peritonitis and 4% others. Catheter replacement was needed in 15 patients. Conclusions PD for ARF in newborns is an easy bedside technique, short-term extrarrenal replacement therapy, with few complications. Special usefulness is seen in cardiac patients after bypass surgery.

Anuria

Oliguria

Renal replacement therapy

Neonatology

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Phase 1 study of two inodilators in neonates undergoing cardiovascular surgery

Pediatric Research (2012)

Adelina Pellicer Joan Riera Paloma López‐Ortego María Carmen Bravo Rosário Madero

Tolerability

Levosimendan

Regimen

10.1038/pr.2012.154

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Citations (49)