Venkataraman Krishnaswami

University of Amsterdam

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

David P. Shreiner

Johnson University

Steven J. Lavine

Wayne State University

Cornelis J.F. Van Noorden

University of Amsterdam

William P. Follansbee

University of Pittsburgh

Erik M. M. Manders

University of Amsterdam

Ron A. Hoebe

University of Amsterdam

P S Reddy

Science Health Allied Research Education

James A. Shaver

University of Pittsburgh Medical Center

Judith H. Murphy

University of Perugia

Morteza Amidi

Klinikum Hanau

Cooperative Institutions

University of Pittsburgh

University of Pittsburgh Medical Center

UPMC Presbyterian

United States Department of Veterans Affairs

University of Amsterdam

Mercy Medical Center

Delft University of Technology

Academic Medical Center

Erasmus MC

Johns Hopkins University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Spatially-controlled illumination microscopy

Quarterly Reviews of Biophysics (2016)

Venkataraman Krishnaswami Cornelis J.F. Van Noorden Erik M. M. Manders Ron A. Hoebe

Abstract Live-cell and live-tissue imaging using fluorescence optical microscopes presents an inherent trade-off between image quality and photodamage. Spatially-controlled illumination microscopy (SCIM) aims to strike the right balance between obtaining good image quality and minimizing the risk of photodamage. In traditional imaging, illumination is performed with a spatially-uniform light dose resulting in spatially-variable detected signals. SCIM adopts an alternative imaging approach where illumination is performed with a spatially-variable light dose resulting in spatially-uniform detected signals. The actual image information of the biological specimen in SCIM is predominantly encoded in the illumination profile. SCIM uses real-time spatial control of illumination in the imaging of fluorescent biological specimens. This alternative imaging paradigm reduces the overall illumination light dose during imaging, which facilitates prolonged imaging of live biological specimens by minimizing photodamage without compromising image quality. Additionally, the dynamic range of a SCIM image is no longer limited by the dynamic range of the detector (or camera), since it employs a uniform detection strategy. The large dynamic range of SCIM is predominantly determined by the illumination profile, and is advantageous for imaging both live and fixed biological specimens. In the present review, the concept and working mechanisms of SCIM are discussed, together with its application in various types of optical microscopes.

Fluorescence-lifetime imaging microscopy

Biological Imaging

10.1017/s0033583516000135

Cite

Citations (7)

A New Test Paradigm for Semiconductor Memories in the Nano-Era

Asian Test Symposium (2011)

Said Hamdioui Venkataraman Krishnaswami Ijeoma Sandra Irobi Zaid Al-Ars

Due to rapid and continuous technology scaling, faults in semiconductor memories (and ICs in general) are becoming pervasive and weak rather than strong, a weak fault is a fault that escape the test program (because it does not cause an error/system failure). However, multiple weak faults may cause an error during the application. Components with weak faults which fail at board and system level are sent to suppliers, but only to have them returned back as No Trouble Found (NTF). This is because the conventional memory test approach assumes the presence of a single defect at a time causing a strong fault (hence an error), and is therefore unable to deal with weak faults. This paper presents a new memory test approach able to detect weak faults, it is based on assuming the presence of multiple weak faults at a time in a memory system rather than a single strong fault at a time. Being able to detect weak faults reduces the number of escapes, hence also the number of NTFs. The experimental analysis done using SPICE simulation for a case of study show that when assuming two simultaneous weak faults, the missing (defect) coverage can be reduced with 10% as compared with the conventional approach.

Spice

10.1109/ats.2011.87

Cite

Citations (3)

Towards digital photon counting cameras for single-molecule optical nanoscopy

Optical Nanoscopy (2014)

Venkataraman Krishnaswami Cornelis J.F. Van Noorden Erik M. M. Manders Ron A. Hoebe

Abstract Background Optical nanoscopy based on separation of single molecules by stochastic switching and subsequent localization allows surpassing the diffraction limit of light. The growing pursuit towards live-cell imaging using nanoscopy demands advancements in both science and technology. Results In this article, we provide an overview of the technological advancements in the development of scientific cameras used for nanoscopy. We discuss the prospects of novel digital photon counting cameras based on a single-photon avalanche diode (SPAD) array camera for optical nanoscopy. Numerical simulations are used to evaluate and compare different scientific cameras for their performance towards single-molecule identification and localization. Conclusion A SPAD array camera with single-photon sensitivity and zero read-out noise allows for the detection of extremely weak signals at ultra-fast imaging speeds. With temporal resolution in the order of micro-seconds, a SPAD array camera offers great potential for live-cell imaging with super-resolution.

Photon Counting

Digital Imaging

Imaging science

10.1186/2192-2853-3-1

Cite

Citations (28)

Unsuspected Purulent Pericarditis Detected by Gallium-67 Scanning

Clinical Nuclear Medicine (1981)

David P. Shreiner Venkataraman Krishnaswami Judith H. Murphy

A Ga-67 scan performed because of a suspected intraabdominal infection demonstrated marked pericardial uptake of the isotope instead, and thus provided the first clue to the diagnosis of purulent pericarditis. Susequent studies and surgery revealed an esophagopericardial fistula, gas in the pericardial sac, and purulent pericarditis casued by multiple bacteria. This report presents an unusual cause of pericardil uptake of Ga-67. The use of Ga-67 scanning to diagnose purulent pericarditis in the absence of typical clinical findings is illustrated.

Isotopes of gallium

Pericardial fluid

10.1097/00003072-198109000-00007

Cite

Citations (12)

Exercise-induced coronary spasm: Role of myocardial scintigraphy in noninvasive detection

American Heart Journal (1981)

Venkataraman Krishnaswami Judith H. Murphy David P. Shreiner

10.1016/0002-8703(81)90149-6

Cite

Citations (0)

Unconventional etiology for heart failure and stroke: Non-compaction cardiomyopathy

International Journal of Case Reports and Images (2013)

Srikanth Seethala Srinivasa Jampana Gur C. Adhar Venkataraman Krishnaswami Thomas Generalovich

Introduction: Noncompaction cardiomyopathy is a rare, primary, genetic cardiomyopathy that results from intrauterine arrest of the compaction process.It commonly involves the apical area of the left ventricle, and uncommonly involves the right ventricle.Case Report: A 45yearold male presented to the hospital for heart failure.He was started on anticoagulation for the apical thrombus and later he suffered cerebrovascular accident.On careful evaluation he was found to have ventricular noncompaction both in right and left ventricles.Conclusion: Noncompaction cardiomyopathy should be considered in all refractory cases of heart failure.Anticoagulation is crucial in patients with decreased systolic function and atrial fibrillation.

Etiology

Electronic journal

Stroke

10.5348/ijcri-2013-02-278-cr-12

Cite

Citations (0)

Left ventricular diastolic filling in patients with coronary artery disease and normal left ventricular function

American Heart Journal (1985)

Steven J. Lavine Venkataraman Krishnaswami David P. Shreiner William P. Follansbee P S Reddy

Ventricular Function

10.1016/0002-8703(85)90150-4

Cite

Citations (21)

Clinical Spectrum of Congestive Heart Failure in the Elderly Population.

PubMed (1995)

Venkataraman Krishnaswami Kesavulureddy Ramireddy Alma E. Heyl

One hundred and fifty-two patients with congestive heart failure above 65 years of age were treated at The Mercy Hospital of Pittsburgh in the calendar year 1992, forming 38% of the total number of inpatients with this condition for that year. Hypertension, ischemic heart disease, and valvular diseases were the common etiological factors. Evidence for diastolic dysfunction was seen in 34% of patients by echocardiographic Doppler study. Atrial fibrillation was the most common arrhythmia. Acute or subacute dyspnea was the most common presenting symptom. Response to conventional treatment was excellent but readmissions for recurrence of congestive heart failure were very common. The in-hospital mortality of these patients in that year was 6%. The possible precipitating factors for recurrent admissions are discussed. In order to favorably control precipitating factors and reduce readmissions, a multicenter registry of congestive heart failure in the elderly is suggested.

Etiology

valvular heart disease

Source

Cite

Citations (5)

Exploring the Potential of Phase Change Memories as an Alternative to DRAM Technology

World Academy of Science, Engineering and Technology, International Journal of Computer, Electrical, Automation, Control and Information Engineering (2010)

Venkataraman Krishnaswami Venkatasubramanian Viswanathan

Dram

Phase-change memory

Source

Cite