In order to progress team cooperative work, it is desirable that each member can not only refer to the shared resouwes, but also maintain his/her own private resources. In our previow paper, we proposed a database system in which wers could maintain private data in their own private work spaces and use the shared data in a shared work space. In this paper, we propose a data management model where private and shared versions can be bound easily. Assume that, a user creates certain data and migrates a copy of the data to the shared work space. When the creator improves the data in the shared work space, he/she often refers the private versions left an the private work space. It is important to provide the whole history of versions.
Abstract: A case of water intoxication with remarkable hyponatremia was investigated with a special reference to EEG changes during and after the episode. The patient recovered his EEG as his consciousness disturbance had improved through an intravenous infusion of high osmolality saline, correlating with the serum sodium level. Further, the clinical importance of recording EEG for water intoxication was stressed.
This paper presents the design, implementation, and evaluation of a sports tactics analysis supporting system. In the field of sports, tactics analysis is conducted using data from multiplayer games. In so doing, it is important to recognize the actual play in a sports game. This research focuses on reproducing player action in sports games. Unlike the conventional systems that only display static images of the players, this proposal system shows the player moving in a manner similar to a game in virtual space that reproduces the pitch, so user is able to have realistic image of game, and therefore the user acquires proper spatial information. The system also allows the user to move the object by touching a display. Consequently, it provides an environment in which users can easily discuss the game. From experiments, we confirmed the system facilitates users in tactics analysis.
Abstract [Introduction] FF-10850, a novel liposomal topotecan, has shown superior anti-tumor effects and a favorable safety profile compared with topotecan or doxorubicin HCl liposome injection (lipo-dox). In the present study, we evaluated the tissue distribution, pharmacodynamics, and payload release of FF-10850 to further characterize mechanisms for enhanced activity and improved safety. [Methods] ES-2 ovarian cancer cells were inoculated into nude mice by subcutaneous or intraperitoneal injection. Topotecan concentration and the ratio of p-H2AX/H2AX were measured by LC-MS/MS in tumor and bone marrow, respectively. FF-10850-internalized cell types in tumor were classified by flow cytometry using fluorescent-labeled FF-10850. Topotecan released from FF-10850-internalized cells was quantified in cell culture supernatants by LC-MS/MS. Payload released from the liposomal membranes of either FF-10850 or lipo-dox was quantified by ultracentrifugation/LC-MS/MS following incubation in tumor interstitial fluid and ammonia-containing buffer. [Results] Kinetic analysis of topotecan concentration and p-H2AX/H2AX ratio in tumor and bone marrow, after FF-10850 or topotecan injection, revealed that FF-10850 exerted profound drug exposure and DNA damage, preferentially in tumor. These findings were consistent with superior anti-tumor effects and a favorable safety profile of FF-10850 previously observed in both subcutaneous tumor models and in a clinically relevant intraperitoneally disseminated tumor model. Immunophenotyping revealed internalization of FF-10850 by tumor associated phagocytes. Evaluation of payload release confirmed topotecan was released from FF-10850-internalized cells into the extracellular space, and additionally from FF-10850 but not lipo-dox liposomal membranes during incubation in tumor interstitial fluid. A higher concentration of ammonia detected in the tumor interstitial fluid compared to that in plasma. Ammonia-containing buffer was shown to induce payload release from FF-10850 but not from lipo-dox membranes. [Conclusions] These data suggest that FF-10850 preferentially accumulates in tumor, presumably via the enhanced permeability and retention effect, and efficiently releases payload through dual mechanisms in tumor. One mechanism is mediated by tumor associated phagocytes, which internalize FF-10850 and release payload into the extracellular space. An additional mechanism is mediated by ammonia, which is reported to be a metabolite in glutaminolysis activated by the metabolic shift in tumor cells. These characteristics of FF-10850 distribution and release may translate to enhanced anti-tumor effects of FF-10850 as observed in subcutaneous as well as intraperitoneally disseminated tumor models closely resembling clinical conditions. Citation Format: Susumu Shimoyama, Ken Okada, Toshifumi Kimura, Noriyuki Kasagi, Shinji Nakayama, Keiko Makita-Suzuki, Shun Matsuda, Mikinaga Mori, Kiyohito Takada, Shinji Hagiwara, Takefumi Hara. FF-10850, a novel liposomal topotecan, achieved superior anti-tumor effects and a favorable safety profile via preferential distribution followed by dual payload release mechanisms in tumor [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1228.
Wikipedia is one of the world's largest social production platforms, featuring high quality articles without a central control. Many scholars have investigated how people in creating articles for the online encyclopaedia collaborate with other authors. Wikipedia is available in 288 languages, among which are Finish, Korean, and Japanese, languages which are not spoken outside of the countries in which they originated. Therefore, Wikipedia offers a type of microscope for analysing how people in these local cultures work together. In May 2013, the English Wikipedia introduced a new social function - Wiki-Thanks. This facility enables authors to send thanks to other Wikipedia users who have contributed to or edited their articles. In this paper, we aim to evaluate this new social tool from different cultural perspectives. To achieve this goal, we analyse Wiki-Thanks log events and compare different language editions of Wikipedia - English, German, Spanish, Chinese, Japanese, Korean, and Finnish.
