Wen Zhu

Institute of Agricultural Resources and Regional Planning

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Cun‐Zhi Liu

Beijing University of Chinese Medicine

Xuerui Wang

Capital Medical University

Jing‐Wen Yang

Kunming Medical University

Guang‐Xia Shi

Beijing University of Chinese Medicine

Siqi Du

Tianjin University of Traditional Chinese Medicine

Chao-Qun Yan

Wuhan University

Tian He

Beijing University of Chinese Medicine

Ye Yang

Nanjing University of Chinese Medicine

Xianghong Zeng

Foshan University

Ling‐Yong Xiao

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Cooperative Institutions

Capital Medical University

Beijing University of Chinese Medicine

Beijing Hospital of Traditional Chinese Medicine

Chinese Academy of Agricultural Sciences

Institute of Agricultural Resources and Regional Planning

Chinese Academy of Sciences

Northeast Forestry University

Sichuan University

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

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Differential responses of plant and microbial respiration to extreme precipitation and drought during spring and summer in the Eurasian meadow steppe

Environmental Research (2025)

Tsegaye Gemechu Legesse Jingfeng Xiao Gang Dong Xiaobing Dong Nano Alemu Daba

Steppe

10.1016/j.envres.2025.120883

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The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl4-induced acute liver injury of mice

Free Radical Biology and Medicine (2000)

Wen Zhu P. C. W. Fung

TBARS

Sodium nitroprusside

Thiobarbituric acid

10.1016/s0891-5849(00)00396-8

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Citations (125)

Thioredoxin and cerebral ischemia

Int J Cerebrovasc Dis (2015)

Wen Zhu Xuerui Wang Siqi Du Cai‐Shuo Ji

Ischemic brain injury is closely associated with oxidative stress, neuron loss, and inflammatory reaction. The thioredoxin system is an important antioxidant system in human body. It plays the important roles in the process of fighting against oxidative stress damage, inhibiting apoptosis and inflammation. In recent years, the roles of thioredoxin system in cerebral ischemia have attracted more and more attention. This article reviews the roles of thioredoxin in cerebral ischemia. Key words: Brain Ischemia; Thioredoxins; Oxidative Stress; Apoptosis; Inflammation; Neuroprotective Agents

10.3760/cma.j.issn.1673-4165.2015.12.011

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Consecutive annual mowing reduces soil respiration and increases the proportion of autotrophic component in a meadow steppe

Ecological Processes (2024)

Wen Zhu Tsegaye Gemechu Legesse Xiaobing Dong Aogui Li Ziyue Shi

Abstract Bcakground Soil respiration (Rs), as the second largest CO 2 emissions of terrestrial ecosystems, is sensitive to disturbance and consequent environmental changes. Mowing is strategically implemented as an management approach and has the potential to influence carbon cycling in meadow steppes. However, it remains unclear how and why Rs and its heterotrophic (Rh) and autotrophic (Ra) components respond to consecutive mowing and associated ecological consequences. Here, we conducted a field mowing experiment in a meadow steppe in 2018 and monitored Rs, Rh, and Ra from 2019 to 2022. Results We observed a significant reduction in Rs by 4.8% across four years, primarily attributed to a decrease in Rh. This decline in Rs intensified over time, indicating an accumulative effect of mowing. In addition, mowing induced an generally increasing Ra/Rs ratio over the experimental years with a simultaneous increase in the ratio of belowground to aboveground biomass (BGB/AGB). Furthermore, structural equation modeling results revealed that the decline in Rs was largely ascribed to reduced microbial biomass carbon (MBC) under mowing, while the increased Ra/Rs was primarily explained by the enhanced BGB/AGB. Partial regression analysis suggested that the biotic factor of microbial biomass dominated changes in soil respiration induced by mowing rather than abiotic soil temperature. Conclusions Our findings showed that consecutive mowing decreased Rs and raised Ra/Rs in meadow steppe by decreasing plant biomass and altering the proportion of biomass allocation. This observed decline in Rs would help to reduce CO 2 concentration in atmosphere as well as alleviate global warming. However, considering the concurrent lower microbial biomass, the potential positive impacts of mowing on climate and ecosystem function should be reevaluated in future grassland management practices.

Steppe

Soil respiration

Component (thermodynamics)

Ecosystem respiration

Autotroph

10.1186/s13717-024-00537-1

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Anti-oxidative and Anti-apoptotic Effects of Acupuncture: Role of Thioredoxin-1 in the Hippocampus of Vascular Dementia Rats

Neuroscience (2018)

Wen Zhu Xuerui Wang Siqi Du Chao-Qun Yan Nana Yang

Vascular dementia

Nissl body

10.1016/j.neuroscience.2018.03.029

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Acupuncture inhibits TXNIP‐associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats

CNS Neuroscience & Therapeutics (2017)

Siqi Du Xuerui Wang Wen Zhu Ye Yang Jing‐Wen Yang

Summary Aims Oxidative stress and inflammation have been implicated in the pathogenesis of vascular dementia (VD). Thioredoxin‐interacting protein (TXNIP) plays a vital role in oxidative stress and NOD‐like receptor protein 3 (NLRP3) inflammasome activation. There is evidence that acupuncture has an antioxidative and neuroprotective effect in VD. In this study, we investigated whether acupuncture can attenuate cognitive impairment via inhibiting TXNIP‐associated oxidative stress and inflammation in VD rats. Methods Both common carotid arteries were occluded (2‐vessel occlusion [2VO]) in rats to model VD. The neuroprotective effect of acupuncture was assessed by the Morris water maze and Nissl staining. Oxidative stress was assessed by detecting levels of reactive oxygen species, DNA oxidation, and antioxidase. Western blot, real‐time PCR, and immunofluorescence were used to detect the expression of TXNIP, NLRP3, caspase‐1, and IL‐1β. A TXNIP siRNA intraventricular injection was applied to investigate whether acupuncture mimicked the effect of TXNIP inhibitor. Results Our findings demonstrated that VD rats treated with acupuncture had reduced hippocampal neuronal loss and oxidative stress. The upregulation of TXNIP, NLRP3, caspase‐1, and IL‐1β induced by 2VO was also reversed by acupuncture. Furthermore, TXNIP siRNA had a similar effect as acupuncture on cognition, hippocampal neurons, and ROS production in VD rats. Conclusion In conclusion, our study suggests that the neuroprotective effects of acupuncture in VD are mediated through reducing expression of TXNIP‐associated oxidative stress and inflammation.

Vascular dementia

Thioredoxin-Interacting Protein

10.1111/cns.12773

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Citations (117)

Efficacy of cervical paravertebral nerve block under ultrasound guidance combined with nerve stimulator localization in the treatment of cervical spondylosis of nerve-root type

Pain Clin J (2016)

Wen Zhu Wen Shen Yuan Yan Liang Dong Liping Chen

Objective To observe the curative effects of cervical paravertebral nerve block under ultrasound guidance combined with nerve stimulator localization for cervical spondylosis of nerve-root type. Methods One hundred and twenty patients with cervical spondylosis of nerve-root type were enrolled and treated by cervical paravertebral nerve block under ultrasound guidance combined with nerve stimulator localization. Visual analogue scale (VAS) was observed before treatment and at 1 day, 1 week and 3 months after the treatment. The effects were assessed by modified MacNab method at 3 months after the treatment. Results The VAS decreased significantly at 1 day (2.3±0.6) , 1 week (2.2±0.4) , and 3 months (1.9±0.4) after the treatment as compared with pre-treatment (7.2±0.5) (P 0.05) . Sixty-five patients (54.2%) showed excellent effect, 44 patients (36.7%) good effect, 8 patients (6.7%) acceptable effect and 3 patients (2.5%) poor effect. The excellent and good rate was 90.8% (109/120 cases) and the CASCS increased at 3 months after the treatment as compared with pre-treatment (P<0.05) , without adverse reaction. Conclusion The cervical paravertevral nerve block under ultrasound guidance combined with nerve stimulator localization is a safe and effective method in the treatment of cervical spondylosis of nerve-root type. Key words: Ultrasound guidance; Nerve stimulator; Nerve-root type cervical spondylosis

Cervical spondylosis

Cervical Nerve

Nerve stimulator

10.3760/cma.j.issn.1672-9633.2016.04.005

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Mechanisms of acupuncture on vascular dementia—A review of animal studies

Neurochemistry International (2016)

Ye Yang Wen Zhu Xuerui Wang Jing‐Wen Yang Ling‐Yong Xiao

Vascular dementia

10.1016/j.neuint.2016.12.001

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