Marisa Cristina Leite Santos Genelhu

Universidade Vale do Rio Doce

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Geovanni Dantas Cassali

Universidade Federal de Minas Gerais

Helenice Gobbi

Universidade Federal do Triângulo Mineiro

F. A. L. Costa

Universidade Estadual Paulista (Unesp)

Angélica Cavalheiro Bertagnolli

Secretaria de Agricultura e Abastecimento

Antônio Hugo José Fróes Marques Campos

D’Or Institute for Research and Education

Carlos Alberto Ribeiro

Universidade Federal de Minas Gerais

Sérgio Vitorino Cardoso

Universidade Federal de Uberlândia

Luiz Cosme Cotta Malaquias

Universidade Federal de Alfenas

Fernando Augusto Soares

AC Camargo Hospital

Diele C. B. Arantes

Centro Universitário Newton Paiva

Cooperative Institutions

Universidade Federal de Minas Gerais

Universidade Vale do Rio Doce

Universidade Federal de Santa Maria

Universidade Estadual Paulista (Unesp)

Universidade de São Paulo

AC Camargo Hospital

Hospital São Paulo

Universidade Federal do Piauí

D’Or Institute for Research and Education

Universidade Federal do Espírito Santo

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Characterization of nickel-induced allergic contact stomatitis associated with fixed orthodontic appliances

American Journal of Orthodontics and Dentofacial Orthopedics (2005)

Marisa Cristina Leite Santos Genelhu Marcelo Marigo Lucia F. Alves‐Oliveira Luiz Cosme Cotta Malaquias Ricardo Santiago Gomez

Etiology

Medical History

Inflammatory response

10.1016/j.ajodo.2005.03.002

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Citations (75)

Immunolocalization of β-Catenin in Pleomorphic Adenomas and Carcinomas Ex-pleomorphic Adenomas of Salivary Glands

Applied immunohistochemistry & molecular morphology (2007)

Marisa Cristina Leite Santos Genelhu Helenice Gobbi Diele C. B. Arantes Sérgio Vitorino Cardoso Geovanni Dantas Cassali

β-catenin plays a central role in cadherin/catenin cell-cell adhesion complex and is involved in cell signaling pathway. Change in β-catenin distribution has been associated with several human cancers including salivary gland tumors. We studied the immunolocalization of β-catenin in a series of pleomorphic adenomas (PA) and carcinomas ex-pleomorphic adenomas (Ca ex-PA). Ten samples of PA and ten of Ca ex-PA were evaluated by immunohistochemistry using streptavidin-biotin-peroxidase technique and a monoclonal antibody against β-catenin (E-5). Cell membrane/cytoplasmic staining of β-catenin was observed in normal gland parenchyma, PA, and in well-differentiated Ca ex-PA. Cytoplasmic/nuclear β-catenin staining was observed in poorly differentiated carcinomas and, interestingly, in one case of PA. Our data showed decreased cell membrane β-catenin expression in higher-grade tumors suggesting that β-catenin may play an important role in histologic differentiation and transition to malignant phenotype of Ca ex-PA.

Parenchyma

10.1097/01.pai.0000213123.04215.95

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Citations (16)

Immunohistochemical expression of p63 in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands

Oral Oncology (2005)

Marisa Cristina Leite Santos Genelhu Helenice Gobbi Fernando Augusto Soares Antônio Hugo José Fróes Marques Campos Carlos Alberto Ribeiro

Parenchyma

clone (Java method)

10.1016/j.oraloncology.2005.06.026

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Citations (29)

Immunohistochemical Expression of p63 and ΔNp63 in Mixed Tumors of Canine Mammary Glands and Its Relation with p53 Expression

Veterinary Pathology (2009)

Angélica Cavalheiro Bertagnolli Geovanni Dantas Cassali Marisa Cristina Leite Santos Genelhu F. A. L. Costa João Francisco Coelho de Oliveira

The immunohistochemical expression of p63, ΔNp63, and p53 was studied in mixed tumors of canine mammary glands (13 benign mixed tumors and 19 carcinomas arising from benign mixed tumors) to determine the role of p63 and its isoform ΔNp63 in the development of mixed tumors, as well as to assess its relation with p53. P63 was expressed in myoepithelial cells of all benign mixed tumors and in 18 of 19 carcinomas in mixed tumors. The p63-negative carcinoma in mixed tumors was invasive, and a loss of p63 was detected in the other malignant tumors showing a discontinuous p63-stained myoepithelial layer. ΔNp63 was expressed in all benign mixed tumors but only in p63-positive carcinomas in mixed tumors. Despite its positive correlation with p63 expression in carcinomas in mixed tumors ( r = 0.8323, P < .00001), ΔNp63 expression showed a decrease in benign tumors. Positivity for p53 was detected in 2 of 13 and 1 of 19 benign mixed tumors and carcinomas in mixed tumors, respectively. There was no correlation between p63 or ΔNp63 and p53 expression. Our data support the notion that the decrease of p63 expression, in particular of its isoform ΔNp63, seems to be an important factor in the development of carcinomas in mixed tumors.

Mixed tumor

P53 protein

P53 expression

10.1354/vp.08-vp-0128-c-fl

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Citations (31)