K. D. Voigt

University of Veterinary Medicine Hannover, Foundation

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J. Tamm

St. Franziskus Hospital

M. Apostolakis

National and Kapodistrian University of Athens

H. Becker

St. Marien Hospital

W. Bartsch

Universität Hamburg

H. Klein

Universität Hamburg

U. Volkwein

Universität Hamburg

Michael Krieg

Institute of Photonic Sciences

A. Oriol-Bosch

Instituto Nacional de la Salud

W. Rehpenning

Universität Hamburg

I. Beckmann

University of Göttingen

Cooperative Institutions

Universität Hamburg

University Medical Center Hamburg-Eppendorf

University of Freiburg

Universitäts Frauenklinik

Eppendorf (Germany)

MSH Medical School Hamburg – University of Applied Sciences and Medical University

Martini-Klinik

Philipps University of Marburg

TU Dresden

Klinik und Poliklinik für Neurologie

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Quantitative assessment of endogenous testicular and adrenal sex steroids and of steroid metabolizing enzymes in untreated human prostatic cancerous tissue

Journal of Steroid Biochemistry (1988)

H. Klein Mathias Bressel H. Kastendieck K. D. Voigt

Sex steroid

10.1016/0022-4731(88)90084-2

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Citations (32)

ÜBER NEUTRALSTEROIDE IM BLUT

European Journal of Endocrinology (1958)

J. Tamm I. Beckmann K. D. Voigt

Im Rahmen von Untersuchungen über die Neutralsteroide im menschlichen Blut teilten wir erste Ergebnisse mit, die an grösseren Serum- und Plasmamengen durch Chloroformextraktion, Differentialhydrolyse und relativ spezifische, colorimetrische Gruppenreaktionen gewonnen wurden (Tamm, Beckmann & Voigt, 1957). Es handelte sich dabei um relativ rohe Extrakte. Im Verlauf weiterer Experimente zur Identifizierung der einzelnen Steroidindividuen wurden Versuche angestellt, um die Brauchbarkeit der in der Literatur geläufigen Verfahren zur Extraktion und Reinigung der Blutsteroide zu prüfen (Literatur s. b. Tamm, 1956). Im Folgenden sollen die Ergebnisse dieser Untersuchungen dargestellt werden. Über die Isolierungsversuche von Steroiden aus grösseren Plasmamengen mittels Papierchromatographie wird in einer weiteren Mitteilung berichtet werden. Die Schwierigkeit liegt darin begründet, dass im Plasma den kleinen Steroidmengen grosse Anteile an Neutralfetten und Lipiden gegenüberstehen. Wenn man im Durchschnitt 10 μg Cortisol pro 100 ml Plasma annimmt, beträgt das Verhältnis Cortisol: Fett = 1:69 000. Beim Corticosteron liegt die Relation

10.1530/acta.0.0270292

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METABOLISM AND MODE OF ACTION OF ANDROGENS IN TARGET TISSUES OF MALE RATS

European Journal of Endocrinology (1973)

H. Becker E. Grabosch Caroline Hoffmann K. D. Voigt

ABSTRACT Either 1.3 μg [5,6- 3 H]5α-androstane-3,17-dione (27 Ci/m m ), or 12 μg respectively 0.8μg [5,6- 3 H]5α-androstane-3α,17β-diol (3 Ci/m m ), or 12μg respectively 0.8 μg ([5,6- 3 H]5α-androstane-3β,17β-diol (3 Ci/m m ) were administered intravenously to normal adult rats on days 0, 3 and 12 after castration. 30 min after the injection the animals were sacrificed. Total radioactivity counting was performed on aliquots of extracts of blood, peripheral muscle, prostate and seminal vesicles. In the remaining extracts the steroids were isolated by repeated chromatography with and without derivative formation. The following results should be mentioned: 1. Compared to muscle an accumulation of radioactivity is found especially in the prostate on day 3 after castration. 2. Regarding the unconjugated metabolites in plasma no measurable interconversion of both diols has been observed, whereas androstanedione was efficiently metabolised to both diols and to androsterone. In muscle a substantial oxydation of both diols to the corresponding 17-keto-3-hydroxy derivative occurred. 3. In both target organs the three androgens were converted to 5α-DHT 2 ) though in varying amounts. 4. From a calculation of the data available in both target organs a figure of 200 to 300 pg 5α-DHT/mg DNA has been obtained which is regarded as the receptor protein capacity limit. The influence of castration, of enzyme activities and of the chemical structure of the androgens administered on this figure is discussed.

Androstane

10.1530/acta.0.0730407

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Citations (20)

Eine Gasaussaugvorrichtung f�r analytische Zwecke

Analytical and Bioanalytical Chemistry (1905)

K. D. Voigt

10.1007/bf01329907

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[Research on the specificity of some color reactions of steroids and their clinical use].

PubMed (1955)

Dieter Pontius I. Beckmann K. D. Voigt

Source

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Citations (3)

Insulinaemic and glycaemic responses following chages in the order of feeding oats and chopped alfralfa to horses

Pferdeheilkunde Equine Medicine (2005)

Ingrid Vervuert K. D. Voigt N Brüssow Teresa Hollands D. Cuddeford

10.21836/pem20050737

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Citations (3)

Influence of cyproterone acetate on the concentration of dihydrotestosterone, androgen receptor and glandular weight in the rat ventral prostate

European Journal of Endocrinology (1985)

Junfei Huang W. Bartsch K. D. Voigt

Journal Article Influence of cyproterone acetate on the concentration of dihydrotestosterone, androgen receptor and glandular weight in the rat ventral prostate Get access J K Huang, J K Huang Abteilung Klinische Chemie, II. Medizinische Universitätsklinik, Hamburg Search for other works by this author on: Oxford Academic Google Scholar W Bartsch, W Bartsch Abteilung Klinische Chemie, II. Medizinische Universitätsklinik, Hamburg Search for other works by this author on: Oxford Academic Google Scholar K D Voigt K D Voigt Abteilung Klinische Chemie, II. Medizinische Universitätsklinik, Hamburg Search for other works by this author on: Oxford Academic Google Scholar Acta Endocrinologica (Norway), Volume 110, Issue 1_Supplement_a, Apr 1979, Pages S95–S96, https://doi.org/10.1530/acta.0.109S095 Published: 01 April 1985

Cyproterone

Dihydrotestosterone

10.1530/acta.0.109s095

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Die Rolle des Aldosterons bei der paroxysmalen L�hmung

Klinische Wochenschrift (1963)

H. Dieckmann H. G. Mertens K. D. Voigt U. Volkwein

10.1007/bf01479429

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Citations (8)

Protein-bound carbohydrate-containing constituents of serum and vessel wall in atherosclerosis