G. Liakos

There is increasing evidence that inflammation and hypercoagulability play an important role in the pathophysiology of acute ischaemic stroke. We examined the in-hospital prognostic value on mortality of C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha), fibrinogen and D-dimer in middle-aged ischaemic stroke patients.We recruited 231 consecutive patients <66 years with acute ischaemic stroke. CRP, TNF-alpha, fibrinogen and D-dimer levels were determined within 12 h from admission.Fifteen (6.5%) patients died during hospitalization. CRP, fibrinogen and D-dimer levels were significantly higher in patients who died compared with those who survived but only CRP and fibrinogen were independently associated with death, after adjusting for various confounding factors. For 1 mg/l increase in CRP there was a 20% higher risk of dying while for 10 mg/dl increase in fibrinogen the additive risk was 18%. CRP levels >18 mg/l and fibrinogen levels >490 mg/dl were the optimal points that discriminated those who died from the rest.CRP and fibrinogen levels can predict independently the risk of early death in middle-aged ischaemic stroke patients emphasizing the role of inflammation and coagulation in the evolution of ischaemic stroke.

D-dimer

Stroke

Ischaemic stroke

10.1111/j.1600-0404.2007.00971.x

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Citations (43)

686 THE SHORT-TERM EFFECT OF MEDITERRANEAN-TYPE DIET ON SERUM INFLAMMATORY MARKERS IN SUBJECTS WITH ABDOMINAL OBESITY

Atherosclerosis Supplements (2011)

Lοukianos S. Rallidis Anastasia Kolomvotsou J. Lekakis Paul Farajian G. Vamvakou

Abdominal obesity

Mediterranean Diet

10.1016/s1567-5688(11)70687-0

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P641Lipoprotein (a) and premature myocardial infarction

European Heart Journal (2017)

Lοukianos S. Rallidis Demosthenes B. Panagiotakos G. Pavlakis Christos Kotakos G. Liakos

Lipids / Exercise testing and training 121graphics including age, gender and coronary risk factors between patients with and without cholesterol crystal.With regard to lipid profiles, while LDL-C level was similar in two groups (2.1±0.6 vs. 2.2±0.6 mmol/l, p=0.28), a higher level of TG (median: 1.5 vs. 1.0 mmol/l, p=0.002) and a lower level of HDL-C (1.0±0.2 vs. 1.2±0.3mmol/l, p=0.04) were observed in patients with cholesterol crystal (Figure).On multivariate analysis, triglyceride level was an independent predictor contributing to cholesterol crystallization at culprit lesion in patients with CAD who treated with a statin (Figure ).Figure 1 Conclusions: Despite statin therapy, cholesterol crystal was existed at culprit lesion in around 60% of patients with CAD requiring PCI.Triglyceride level was independently associated with the presence of cholesterol crystal showing more vulnerable plaque features.This finding may support potential benefit to lower triglyceride level for modulating cholesterol crystal leading to plaque stabilization and reducing residual risk of statin treatment.

10.1093/eurheartj/ehx501.p641

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THE PREVALENCE OF METABOLIC SYNDROME IN CORONARY HEART DISEASE PATIENTS AND ITS RELATIONSHIP WITH DEPRESSIVE SYMPTOMATOLOGY

Atherosclerosis Supplements (2008)

V. Chariatis Lοukianos S. Rallidis Christos Varounis Panagiotis Vavoulis G. Liakos

10.1016/s1567-5688(08)70532-4

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Reduced carriership of 4G allele of plasminogen activator inhibitor-1 4G/5G polymorphism in very young survivors of myocardial infarction

Journal of Thrombosis and Thrombolysis (2009)

Lοukianos S. Rallidis Argyri Gialeraki Efrosyni Merkouri G. Liakos Nikolaos Dagres