Mary E. Gray

Vanderbilt University

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Mildred T. Stahlman

Vanderbilt University

Jeffrey A. Whitsett

Cincinnati Children's Hospital Medical Center

Virgil S. LeQuire

Vanderbilt University

Håkan Sundell

University of Borås

Mahlon D. Johnson

University of Rochester

Larry L. Swift

Vanderbilt University Medical Center

R. Blake Pepinsky

Biogen (United States)

Richard M. France

Eye Care Associates

William M. Hull

Queen Mary University of London

András Khoór

Mayo Clinic in Florida

Cooperative Institutions

Vanderbilt University

Vanderbilt University Medical Center

Cincinnati Children's Hospital Medical Center

University of Cincinnati

University of Cincinnati Medical Center

Johns Hopkins University

National Institutes of Health

University of California, San Francisco

Johns Hopkins Medicine

Nashville Oncology Associates

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Ontogeny of Epidermal Growth Factor Receptor/Kinase and of Lipocortin-1 in the Ovine Lung

Pediatric Research (1989)

Mahlon D. Johnson Mary E. Gray Graham Carpenter R. Blake Pepinsky Håkan Sundell

Annexin A1

Immunostaining

10.1203/00006450-198905000-00022

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Citations (32)

Pulmonary Lipocytes in the Production of Interstitial Fibrosis. † 1598

Pediatric Research (1997)

Mildred T. Stahlman Eric S. Palmer Leslie I. Gold Mary E. Gray

Myofibroblast

Immunostaining

Transdifferentiation

10.1203/00006450-199704001-01617

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Developmental expression of SP-A and SP-A mRNA in the proximal and distal respiratory epithelium in the human fetus and newborn.

Journal of Histochemistry & Cytochemistry (1993)

András Khoór Mary E. Gray William M. Hull Jeffrey A. Whitsett Mildred T. Stahlman

We used immunolocalization and in situ hybridization to determine the distribution of SP-A and SP-A mRNA in lungs of human fetuses and normal newborn infants. Early in the second fetal trimester a few immunostained cells were observed in tracheal epithelium, often in mucosal folds near the origin of submucosal gland ducts. Non-mucous tracheal gland cells were immunostained for SP-A as they became differentiated. Expression of SP-A mRNA was similar to that of immunolocalization in the second trimester. Immunostained cells and SP-A mRNA also appeared about the same time in gestation in isolated cells of bronchial epithelium and glands. SP-A mRNA was seen in bronchiolar cells and pre-Type II cells lining terminal airways of fetuses at 19-20 weeks of gestation. Only in liveborn infants did cells of bronchioloalveolar portals and mature Type II cells contain SP-A mRNA or immunostain for SP-A. In postnatal infants, luminal material was also stained for SP-A. Although some alveolar macrophages contained immunoreactive material, SP-A mRNA was never detected. The abundance of SP-A in tracheal and bronchial glands and epithelium of conducting airways supports the importance of non-surfactant-associated functions for SP-A and may be related to a role in host defense.

Submucosal glands

Immunostaining

10.1177/41.9.8354874

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Citations (141)

The effects of ACTH on lung maturation in fetal lambs.

PubMed (1979)

Håkan Sundell Mary E. Gray Jean-Pierre Relier I Z Kovar William Z Catterton

Hyaline

Lamellar granule

Adrenocorticotrophic hormone

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Citations (11)

ACCELERATOR FACTORS IN HEMOPHILIC BLOOD

American Journal of Physiology-Legacy Content (1950)

William Orr Mary E. Gray

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10.1152/ajplegacy.1950.163.1.148

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Citations (1)

Immunolocalization of Surfactant Protein-D (SP-D) in Human Fetal, Newborn, and Adult Tissues

Journal of Histochemistry & Cytochemistry (2002)

Mildred T. Stahlman Mary E. Gray William M. Hull Jeffrey A. Whitsett

Immunoreactive surfactant protein-D (SP-D) was assessed in human fetal, newborn, and adult tissues. In the fetal lung, SP-D was detected on airway surfaces by 10 weeks' gestation, staining increasing in the distal airways, decreasing in the proximal conducting airways with advancing gestation. In lungs from near-term infants and adults, SP-D was detected in Type II cells, serous cells of tracheobronchial glands, and subsets of cells lining peripheral airways. Immunostaining was decreased or absent in areas of lungs of neonates after injury to Type II cells, infection, or hemorrhage and was decreased in collapsed or unseptated airways from older infants with bronchopulmonary dysplasia. SP-D was also detected in many organs at all ages. SP-D was readily detected in epithelial cells and luminal material in lacrimal glands, salivary glands, pancreas, bile ducts, renal tubules, esophageal muscle and glands, parietal cells of the stomach, crypts of Lieberkuhn, sebaceous and eccrine sweat glands, Von Ebner's glands, endocervical glands, seminal vesicles, adrenal cortex, myocardium, and anterior pituitary gland. SP-D is a widely distributed member of the “collectin” family of polypeptides secreted onto luminal surfaces by epithelial cells lining ducts of many organs, where it likely plays a role in innate host defense.

10.1177/002215540205000506

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Citations (139)

The CT appearance of conjoined nerve roots and differentiation from a herniated nucleus pulposus.

Radiology (1982)

C A Helms R H Dorwart Mary E. Gray

Lumbosacral joint

10.1148/radiology.144.4.7111728

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Citations (42)

Lung vascular permeability changes in lambs with hyaline membrane disease.

PubMed (1989)

Håkan Sundell Jens B. Grøgaard Jorge Rojas Mary E. Gray Petaiah Mohan

To investigate the mechanism of pulmonary edema in hyaline membrane disease (HMD), lymph from the efferent duct of the mediastinal lymph node was collected in premature lambs before and after delivery by cesarean section. Mean lymph flow in 7 lambs with histologically verified HMD increased progressively over 4 h after delivery to 3 times the fetal value, while lymph flow in 7 lambs without HMD increased to 3.5 times at 1 h and decreased thereafter. At 4 h after birth, lung lymph flow was significantly higher in lambs with HMD than in lambs without HMD (0.70 +/- 0.15 (SEM) vs 0.43 +/- 0.07 ml.h-1.kg-1). Lymph/plasma concentration ratio for small endogenous protein fractions (effective molecular radius, 3.6 and 3.8 nm) was significantly higher in lambs with HMD than in lambs without HMD at 2-4 h. Postmortem extravascular lung water was significantly higher in lambs with HMD (6.1 +/- 0.5 vs 4.3 +/- 0.3 ml/g dry lung weight). It is concluded that lung water is high in lambs with HMD, which appears to be a result both of delayed absorption of fetal lung liquid and increased permeability of the pulmonary exchange vessels.

Hyaline

Mediastinal lymph node

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Citations (2)

Role of plasma lipoproteins in cortisone-induced fat embolism.

PubMed (1972)

Robert W. Mahley Mary E. Gray Virgil S. LeQuire

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Citations (16)

IMMUNOREACTIVE (I-R) SEROTONIN IN THE DEVELOPING HUMAN LUNG

Pediatric Research (1984)

Mildred T. Stahlman Mary E. Gray A. G. Kasselberg

26 human fetal (8-23 weeks) and 19 live born (24-41 weeks) lungs were examined for the presence of serotonin by immunocytochemistry using horseradish peroxidase bridging technique. Solitary intraepthelial neuroendocrine cells (NEs) and cell clusters (NEBs) were found in developing distal conducting airways as early as 10 weeks gestation and 6/8 first trimester fetal lungs were positive. By 14 weeks gestation many stained NEs and NEBs were present in future bronchi, bronchioles and alveolar ducts. As alveolarization occurred (18-22 weeks) the presence of stained cells at the terminal portion of alveolar ducts in close proximity to invading capillaries was striking and 16/18 second trimester fetal lungs contained many I-R stained cells and cell clusters. After terminal airway differentiation progressed toward term the total number of stained cells appeared to decrease dramatically. 14/19 newborn infants showed few stained cells. Although stained cells were difficult to find in the presence of acute neonatal lung disease, such as HMD, as conducting airway epithelial regeneration occurred with recapitulation of capillary invasion, positively stained NE and NEBs reappeared. This pattern of cells positively stained for I-R serotonin is in contrast to that of both I-R bombesin and I-R calcitonin in the fetal lung. The location of I-R serotonin stained cells at areas of capillary invasion is also more prominent than that of I-R bombesin or I-R calcitonin. It is suggested that serotonin might play a role in the vascularization of terminal airways. Supported by NIH grant HL 14214.

10.1203/00006450-198404001-01877

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