A Baña

Instituto de Investigación Sanitaria de Santiago

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María L. Couce

Complejo Hospitalario Universitario de Santiago

José M. Fraga

Universidade de Santiago de Compostela

Alejandro Pérez‐Muñuzuri

Complejo Hospitalario Universitario de Santiago

Ma Dolores Bóveda

Complejo Hospitalario Universitario de Santiago

S. Toure

Centre Hospitalier Universitaire de Cocody

E Dogba

Centre Hospitalier Universitaire de Cocody

J.M. García-Rielo

Complejo Hospitalario Universitario de Santiago

S. Koné

Université Pelefero Gon Coulibaly

Jose M. Albertos-Castro

Complejo Hospitalario Universitario de Santiago

Ayham Alshweki

Complejo Hospitalario Universitario de Santiago

Cooperative Institutions

Complejo Hospitalario Universitario de Santiago

Universidade de Santiago de Compostela

Instituto de Investigación Sanitaria de Santiago

Centre for Biomedical Network Research on Rare Diseases

Centre Hospitalier Universitaire de Cocody

Complexo Hospitalario Universitario A Coruña

Centro de Investigación Biomédica en Red

Instituto de Salud Carlos III

Instituto de Investigación de Enfermedades Raras

Universidad de Santiago de Chile

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Relevance of urinary S100B protein levels as a short-term prognostic biomarker in asphyxiated infants treated with hypothermia

Medicine (2017)

Ayham Alshweki Alejandro Pérez‐Muñuzuri Olalla López-Suárez A Baña María L. Couce

The initial diagnosis of neonatal hypoxic-ischemic encephalopathy is based on nervous system clinical manifestations. The use of biomarkers to monitor brain injury and evaluate neuroprotective effects allows early intervention and treatment. This study was designed to determine the short-term prognostic significance of urinary S100B calcium-binding protein (S100B) in asphyxiated newborns treated with hypothermia. An observational prospective study was conducted over a period of 5 years in 31 newborns with hypoxic-ischemic encephalopathy who received therapeutic hypothermia. The patients were divided into 2 groups: Group A (13 newborns with a normal neurological examination before discharge) and Group B (18 newborns who died during admission or had an abnormal neurologic examination before discharge). Urinary S100B was the main variable, serum S100B and neuron-specific enolase (NSE) were considered as secondary variables, and all of them were assessed on the first 3 days of life. The newborns were subsequently divided into groups with normal and abnormal electrophysiological and imaging findings. Mean urinary S100B levels were significantly higher in group B than group A on day 1 (10.58 ± 14.82 vs 4.65 ± 9.16 μg/L, P = .031) and day 2 (5.16 ± 7.63 vs 0.88 ± 2.53, P = .002). The optimal cutoff for urinary S100B on day 1 was >1.11 μg/L of (sensitivity, 100%; specificity 60%) for the prediction of neonatal death and < 0.66 μg/L (sensitivity 83% and specificity 70%) for the prediction of a normal neurological examination before discharge. It was not possible to calculate cutoffs with a similar accuracy for serum S100B or NSE. Urinary S100B on day 1 was higher in patients with abnormal magnetic resonance imaging findings (7.89 ± 8.09 vs 4.49 ± 9.14, P = .039) and abnormal positron emission tomography findings (8.60 ± 9.29 vs 4.30 ± 8.28, P = .038). There were no significant differences in S100B levels between patients with normal and abnormal electroencephalography results. Urinary S100B measured in the first days of life can predict neonatal death and short-term prognosis in asphyxiated newborns treated with hypothermia. The method is convenient, noninvasive, and has a higher sensitivity and specificity than measurement of serum S100B or NSE.

Hypoxic-Ischemic Encephalopathy

Enolase

Clinical Significance

Perinatal asphyxia

10.1097/md.0000000000008453

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Citations (21)

Prenatal alcohol exposure and its repercussion on newborns

Journal of Neonatal-Perinatal Medicine (2014)

A Baña María Jesús Tabernero Alejandro Pérez‐Muñuzuri Olalla López-Suárez S. Dosil

BACKGROUND: Alcohol consumption during pregnancy, even when moderate, implies a risk of impaired neurodevelopment, physical impairments and malformations. Its early identification is essential for establishing preventive measures to diminish disabilities among newborns. METHODS: To determine the frequency of consumption of substance use in pregnant women, we have used the techniques of gas chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry to detect drugs and markers of chronic consumption of alcohol in meconium. We performed a prospective study during a period of 10 months among 110 infants in our hospital, assessing anthropometry, neuromuscular development and determination of toxic substances in urine and meconium. Furthermore, meconium analysis identified fatty acid ethyl esters (FAEEs) and ethyl glucuronide (Etg). We also conducted a survey regarding the obstetric history, toxic habits, and employment status of the mothers. RESULTS: According to early detection markers analyzed in meconium (FAEE >1000 ng/g and/or Etg >50 ng/g meconium), 34.65% of pregnant women consumed alcohol during pregnancy, and 17% were positive for both markers. Within the positive cases, 50% of those exceeding a FAEE's value of 5000 ng/g in meconium had low birth-weight children. Only 5/110 mothers (4.5%) admitted to occasional alcohol consumption during pregnancy. Nobody admitted to frequent intake. The cocaine test was positive in three cases; two of them were positive for alcohol as well. CONCLUSION: As expected, many screening devices do not accurately capture use during pregnancy and supplemental methods such as meconium analysis of biomarkers of chronic alcohol consumption may be warranted.

Prenatal Alcohol Exposure

10.3233/npm-1471413

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Citations (13)

Traitement des plaies par le miel à Abidjan

Mali Médical (2016)

S. Koné Seindé Touré A Baña Sa Koné E Dogba

Aims: The authors tested the effectiveness of honey on various kind of wounds. They report in this work, the preliminary results of their study. Materials and methods: This is a prospective study over a period of 12 months was achieved in orthopedic trauma unit of the University Hospital of Cocody Abidjan. Thirty-seven patients with various kind of wounds were included in the study. Honey dressings were made every 48 hours. Results: The evolution of the wounds was satisfactory on bacteriological and local levels, with a shorter healing time. Conclusion: The use of honey in wound treatment dates back to ancient times. Currently we rediscover its healing properties. Because of its high sugar concentration and its acid pH, the honey is undeniably a hyperosmotic environment which inhibits the growth of pathogens. Honey also contains two product groups that act directly as antibacterial agents.

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Evaluation and long-term follow-up of infants with inborn errors of metabolism identified in an expanded screening programme

Molecular Genetics and Metabolism (2011)

María L. Couce Daisy Castiñeiras Ma Dolores Bóveda A Baña José A. Cocho

Hyperphenylalaninemia

10.1016/j.ymgme.2011.09.021

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Citations (82)

[Treatment by honey for skin wounds in Abidjan].

PubMed (2016)

S. Koné S. Toure A Baña Sabré Koné E Dogba

The authors tested the effectiveness of honey on various types of wounds. They report in this work, the preliminary results of their study.This is a prospective study conducted over a period of 12 months in the orthopedic trauma unit of the Cocody Abidjan University Hospital. Thirty-seven patients with various types of wounds were included in the study. Honey dressings were made every 48 hours.The evolution of the wounds was satisfactory on bacteriological and local levels, with a reduced healing time.The use of honey in wound treatment dates back to ancient times. Currently we are rediscover its healing properties. Because of its high sugar concentration and its acidic pH, the honey is undeniably a hyperosmotic environment which inhibits the growth of pathogens. Honey also contains two product groups that act directly as antibacterial agents.Les auteurs ont testé l'efficacité du miel sur les plaies de nature diverses. Ils rapportent dans ce travail, les résultats préliminaires de leur étude.Il s'agit d'une étude prospective sur une période de 12 mois qui fut réalisée au service de traumatologie orthopédie du CHU de Cocody Abidjan. Trente sept patients présentant des plaies de nature diverses ont été inclus dans l'étude. Les pansements au miel étaient faits toutes les 48 heures.L'évolution des plaies fut satisfaisante sur le plan bactériologique et local, avec un raccourcissement des délais de cicatrisation.L'utilisation du miel dans le traitement des plaies remonte à la haute antiquité. Actuellement, on redécouvre ses propriétés cicatrisantes. En raison de sa forte concentration en sucre et de son pH acide, le miel est indéniablement un milieu hyperosmotique qui inhibe la croissance des agents pathogènes. Le miel contient également deux groupes de produits qui agissent directement comme des agents antibactériens.

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Inborn errors of metabolism in a neonatology unit: Impact and long‐term results

Pediatrics International (2010)

María L. Couce A Baña Ma Dolores Bóveda Alejandro Pérez‐Muñuzuri José Ramón Fernández Lorenzo

Inborn errors of metabolism (IEM) have greater repercussions in neonatology units. The goal of our study was to evaluate the impact of IEM in a neonatology unit and the outcome of these neonates.All patients with IEM admitted in our unit were evaluated during an 8-year period for specific diagnosis, clinical features, therapy and long-term neurodevelopment.The study group was comprised of 31 infants, 18 of which required admission to the neonatal intensive care unit (NICU) (1.63% of income) due to severe symptoms. Twenty-two of the 31 had an earlier diagnosis and treatment due to expanded newborn screening, made from the third day of life. The most frequent diagnosis in the NICU, representing 66.66% (12/18), was diseases that cause an endogenous intoxication. Despite the diagnosis by tandem mass spectrometry, many of these patients had severe clinical symptoms prior to the screening results. Aggressive support was often necessary (extracorporeal removal therapy, mechanical ventilation). Death occurred generally in the first year of life (5/6). The death rate in the NICU was 10.3%. The survivors presented higher scores on the Psychomotor Development Index if the diagnosis of the disease was either made or helped by screening. This also depends on the type of disease.Earlier diagnosis by expanded newborn screening and earlier treatment is essential in order to be able to prevent neurological sequelae.

Neonatology

10.1111/j.1442-200x.2010.03177.x

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Anaesthetic Management of a Post Total Laryngectomy Patient Undergoing CABG

Annals of Cardiac Anaesthesia (2005)

Siddharth Bhargava Abhay Kasliwal Sanjay Parashar VinodK Parashar Vipin Kumar Goyal

10.4103/0971-9784.37959

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Citations (4)

Effects of different arachidonic acid supplementation on psychomotor development in very preterm infants; a randomized controlled trial

Nutrition Journal (2015)

Ayham Alshweki Alejandro Pérez‐Muñuzuri A Baña Ma. José de Castro Fernando Andrade

Nutritional supplementation with polyunsaturated fatty acids is important in preterm infants neurodevelopment, but it is not known if the omega-6/omega-3 ratio affects this process. This study was designed to determine the effects of a balanced contribution of arachidonic acid in very preterm newborns fed with formula milk. This was a randomized trial, in which newborns <1500 g and/or <32 weeks gestational age were assigned to one of two groups, based on the milk formula they would receive during the first year of life. Initially, 60 newborns entered the study, but ultimately, group A was composed of 24 newborns, who were given formula milk with an ω-6/ω-3 ratio of 2/1, and Group B was composed of 21 newborns, given formula milk with an ω-6/ω-3 ratio of 1/1. The infants were followed up for two years: growth, visual-evoked potentials, brainstem auditory-evoked potentials, and plasma fatty acids were periodically measured, and psychomotor development was assessed using the Brunet Lézine scale at 24 months corrected age. A control group, for comparison of Brunet Lézine score, was made up of 25 newborns from the SEN1500 project, who were fed exclusively with breast milk. At 12 months, arachidonic acid values were significantly higher in group A than in group B (6.95 ± 1.55 % vs. 4.55 ± 0.78 %), as were polyunsaturated fatty acids (41.02 ± 2.09 % vs. 38.08 ± 2.32 %) achieved a higher average. Group A achieved a higher average Brunet Lézine score at 24 months than group B (99.9 ± 9 vs. 90.8 ± 11, p =0.028). The Brunet Lézine results from group A were compared with the control group results, with very similar scores registered between the two groups (99.9 ± 9 vs. 100.5 ± 7). There were no significant differences in growth or evoked potentials between the two formula groups. Very preterm infants who received formula with an ω-6/ω-3 ratio of 2/1 had higher blood levels of essential fatty acids during the first year of life, and better psychomotor development, compared with very preterm newborns who consumed formula with an ω-6/ω-3 of 1/1. Therefore, formula milk with an arachidonic acid quantity double that of docosahexaenoic acid should be considered for feeding very preterm infants. ClinicalTrials.gov Identifier NCT02503020 .

Clinical nutrition

10.1186/s12937-015-0091-3

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Citations (54)

Utilidad de la distracción mandibular en la secuencia de Pierre Robin en el período neonatal

Anales de Pediatría (2013)

María L. Couce A Baña Alejandro Pérez‐Muñuzuri Jose M. Albertos-Castro J.M. García-Rielo

Pierre Robin syndrome

10.1016/j.anpedi.2013.05.005

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Citations (2)

Usefulness of mandibular distraction in the Pierre Robin sequence in neonates