Jan Sikora

Poznan University of Medical Sciences

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Mariusz Kaczmarek

Poznan University of Medical Sciences

J Zeromski

Poznan University of Medical Sciences

Grzegorz Dworacki

Poznan University of Medical Sciences

Halina Batura‐Gabryel

Poznan University of Medical Sciences

Iwona Mozer‐Lisewska

Poznan University of Medical Sciences

Agata Nowicka

Poznan University of Medical Sciences

Magdalena Frydrychowicz

Poznan University of Medical Sciences

Anna Mania

Poznan University of Medical Sciences

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Małgorzata Łagiedo‐Żelazowska

Poznan University of Medical Sciences

Beata Brajer-Luftmann

Poznan University of Medical Sciences

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Poznan University of Medical Sciences

115

Heliodor Swiecicki Clinical Hospital

Polish Academy of Sciences

Centrum Onkologii

University of Life Sciences in Poznań

University School of Physical Education in Kraków

Charles University

Greater Poland Cancer Center

Weatherford College

Medical University of Lodz

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[Secondary reconstruction following biliary tract injuries. Results and failures].

PubMed (1974)

Jan Sikora W Cereda A Akovbiantz

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Citations (1)

Effect of HPV Vaccination on Virus Disappearance in Cervical Samples of a Cohort of HPV-Positive Polish Patients

Journal of Clinical Medicine (2023)

Dominik Pruski Sonja Millert-Kalińska Małgorzata Łagiedo‐Żelazowska Jan Sikora Robert Jach

The introduction of human papillomavirus vaccines revolutionized cervical cancer prevention. Our research hypothesis is that HPV vaccination affects the remission of HPV in cervical swabs. We provide a prospective, ongoing, 24-month, non-randomized study in HPV-positive women. We enrolled 60 patients with positive HPV swabs from the cervix (fifty-one vaccinated with the nine-valent vaccine against HPV and nine unvaccinated). Using an enzyme-linked immunosorbent assay, we determined IgG class antibodies of HPV in the patients' serums. Persistent HPV infection after vaccination was significantly less frequent in the nine-valent vaccinated group (23.5%) compared to the control group (88.9%; p < 0.001). Antibody level after vaccination was significantly higher in the vaccinated patients compared to the control group. The reactive antibody level was seen in the case of all patients in the vaccinated group and one-third of the unvaccinated group (33.3%, n = 3). The vaccination of HPV-positive patients may increase the chance of HPV remission in cervical swabs and may be a worthwhile element of secondary prevention in HPV-positive patients.

10.3390/jcm12247592

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Citations (11)

P1099 EXPRESSION OF NK CELL RECEPTORS AS A PREDICTOR OF TREATMENT RESPONSE IN CHILDREN WITH CHRONIC HEPATITIS C

Journal of Hepatology (2014)

Anna Mania Mariusz Kaczmarek P. Kemnitz Iwona Mozer‐Lisewska Marek Figlerowicz

Telaprevir

Hepatitis C

10.1016/s0168-8278(14)61259-9

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Radioimmunoassay of Dibenzazepines and Dibenzcycloheptanodienes in Body Fluids and Tissues

Clinical Chemistry and Laboratory Medicine (CCLM) (1991)

R Krulík Joachim Exner K. Fuksová Dana Píchová D Beitlová

Article Radioimmunoassay of Dibenzazepines and Dibenzcycloheptanodienes in Body Fluids and Tissues was published on January 1, 1991 in the journal Clinical Chemistry and Laboratory Medicine (CCLM) (volume 29, issue 12).

Body fluid

10.1515/cclm.1991.29.12.827

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Citations (6)

Regulatory T cells in malignant pleural effusions subsequent to lung carcinoma and their impact on the course of the disease

Immunobiology (2016)

Joanna Budna L Spychalski Mariusz Kaczmarek Magdalena Frydrychowicz Joanna Goździk-Spychalska

Pleural disease

10.1016/j.imbio.2016.10.017

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Citations (17)

Phagocytic Activity of Polymorphonuclear Leukocytes Lavaged from the Lungs of Horses with Clinically Diagnosed Chronic Pulmonary Disease

Journal of Veterinary Medicine Series A (1994)

W. Kluciński A. Winnicka Michal A. Olszewski Jan Sikora E Sitarska

Summary The aim of this study was to compare phagocytic activity of polymorphonuclear cells (PMNs) from the bronchoalveolar lavage of clinically healthy horses and those with severe chronic bronchiolitis. Research was carried out on 28 horses. Chronic inflammation of the lower airways was diagnosed in nine horses. Cells from the respiratory tract were lavaged according to accepted methods. For comparison, PMNs were isolated from peripheral blood of all investigated horses. The phagocytic activity of PMNs was determined in relation to two standard strains of Staphylococcus aureus, Staph. aureus Smith which was phagocytized after previous opsonization, and Staph. aureus 305, phagocytized without opsonization. From the investigations, it is shown that the PMNs present in the terminal airways of horses with severe chronic bronchiolitis are characterized by decreased phagocytic activity in relation to opsonized Staphylococcus aureus Smith and increased activity in relation to non‐opsonized Staphylococcus aureus 305, as compared to the PMNs lavaged from the terminal airways of clinically healthy horses. No changes in the phagocytic activity of the peripheral blood PMNs were observed between clinically diseased horses and healthy horses.

Antibody opsonization

Respiratory burst

Respiratory tract

10.1111/j.1439-0442.1994.tb00123.x

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Citations (11)

DeterminationofmRNAthreeToll-like receptorsinhumancarcinomacelllines

Bartosz Brzezicha Joanna Budna Magdalena Frydrychowicz Agata Kolecka Iwona Mozer‐Lisewska

Toll-like receptors (TLRs) are now considered to be active players in tumor-host interactions. Tolllike receptor protein expression on/in cancer cell depends apparently on the level of RNA transcription. Based on previous work showing presence of TLR mRNA in six carcinoma cell lines, it was attempted to determine quantitatively mRNA of TLR-2, TLR-3 and TLR-4 by rt PCR. It has been shown that the expression of mRNA of three TLRs tested was uneven among examined cell lines. These data imply that in any future anti-tumor immunotherapeutic trials involving TLRs it seems mandatory to determine pre cisely TLR mRNA of cancer cells.

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Hepatitis E virus IgG seroprevalence in HIV patients and blood donors, west-central Poland

International Journal of Infectious Diseases (2017)

Maciej Bura Małgorzata Łagiedo‐Żelazowska Michał Michalak Jan Sikora Iwona Mozer‐Lisewska

ObjectiveTo assess hepatitis E virus (HEV) seroprevalence in HIV patients and blood donors from one region in Poland.MethodsA group of 490 persons (244 HIV patients and 246 blood donors) aged 18–55 years were examined using the anti-HEV IgG assay (Wantai Biological Pharmacy Enterprise, Beijing, China). An analysis of the association between certain factors and the presence of this HEV exposure marker was conducted in both groups.ResultsAn HEV seropositivity rate of 50.2% was found. There was no difference in HEV seroprevalence between blood donors (49.6%, 122/246) and HIV patients (50.8%, 124/244) (p = 0.569). The anti-HEV IgG positivity rate increased with age as follows: 36.2% (59/163) in persons aged 18–30 years, 52.0% (92/177) in individuals aged 31–40 years and 63.3% (95/150) in those aged 41–55 years. HEV infection occurred in 56.4% (31/55) of people who had never travelled abroad.ConclusionsWielkopolska Region in west-central Poland is an area hyperendemic for HEV infection. In this part of Poland, the exposure of HIV-positive persons to this virus is not greater than that of healthy blood donors.

Seroprevalence

Hepatitis E Virus

10.1016/j.ijid.2017.05.014

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Citations (37)

The effect of drugs interacting with serotonergic 5HT3 and 5HT4 receptors on morphine place conditioning.

PubMed (1993)

Adam Bisaga Jan Sikora Wojciech Kostowski

The effect of 5HT3 and 5HT4 active compounds on the motivational properties of morphine has been examined in the place conditioning (PC) paradigm using unbiased procedure. Place conditioning with morphine produced significant place preference. Pretreatment with the DAU 6285 (mixed 5HT3 antagonist--5HT4 antagonist) abolished morphine-induced PC. Ondansetron (selective 5HT3 antagonist) attenuated morphine place preference at the dose of 0.1 mg/kg. BIMU 8 (mixed 5HT3 antagonist--5HT4 agonist) failed to modify morphine PC in the 0.001-0.1 mg/kg dose range. While ondansetron given alone failed to produce place conditioning, pairing of BIMU 8 (0.001 mg/kg) induced significant place preference. On the other hand, animals were frequently avoiding compartment paired with the injection of DAU 6285. These findings suggest that 5-hydroxytryptamine by means of 5HT4 receptors mediates appetitive properties of morphine induced-stimuli and suggest that 5HT4 receptor may be involved in the brain reward and reinforcement processes.

Conditioned place preference

Ondansetron

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Citations (19)

Pluripotency transcription factors in lung cancer—a review

Tumor Biology (2015)

Sylwia Sławek-Szmyt Krzysztof Szmyt Maciej Fularz Joanna Dziudzia Maciej Boruczkowski

Lung cancer is the leading cause of cancer-related mortality worldwide. Diagnosis of lung cancer in an early stage is still a challenge due to the asymptomatic course of early stages of the disease and the lack of a standard screening program for the population. Nowadays, learning about the mechanisms that lead to cancerogenesis in the lung is crucial for the development of new diagnostic and therapeutic strategies. Recently, many studies have proved that cancer stem cells (CSCs) are responsible for the initiation, progression, metastasis, recurrence, and even resistance of chemo- and radiotherapeutic treatment in patients with lung cancer. The expression of pluripotency transcription factors is responsible for stemness properties. In this review, we summarize the current knowledge on the role of CSCs and pluripotency transcription factors in lung carcinogenesis.

10.1007/s13277-015-4407-x

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Citations (31)