John Morris

University of Utah

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Greg J. Norman

University of Chicago

A. Courtney DeVries

West Virginia University

Howard Smart

Royal Liverpool University Hospital

Adrian J. Stanley

Glasgow Royal Infirmary

Kate Karelina

Blanchette Rockefeller Neurosciences Institute

Brian Calcraft

St Cadoc's Hospital

J F Mayberry

Nuffield Health

Randy J. Nelson

West Virginia University

John Rhodes

Yale University

Zachary M. Weil

The Ohio State University

Cooperative Institutions

University College London

Zoological Society of London

Fauna and Flora International

London Borough of Camden

University of Edinburgh

Istituti di Ricovero e Cura a Carattere Scientifico

University Gastroenterology

Glasgow Royal Infirmary

Western General Hospital

NHS Greater Glasgow and Clyde

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Upper gastrointestinal bleeding in Scotland 2000‐2015: trends in demographics, aetiology and outcomes

Alimentary Pharmacology & Therapeutics (2020)

Sardar Chaudhary Daniel Mackay Jill P. Pell John Morris Nicholas I. Church

Summary Background Upper gastrointestinal bleeding (UGIB) remains a common cause of presentation and admission to hospital in the UK, with the incidence in Scotland one of the highest in the world. Aims To investigate the difference in demographics, deprivation quintiles, aetiology of bleeding and clinical outcomes in patients presenting with UGIB to hospitals across Scotland over a 16‐year period Methods Data were collected using the National Data Catalogue and analysed retrospectively using the National Safe Haven. Results We included 129 404 patients. The annual number of patients presenting with UGIB remained similar over the 16‐year period. Mean age at admission increased from 59.2 to 61.4 years. There was a significant drop in variceal bleeding over time from 2.2% to 1.7% ( P < 0.001). The incidence of UGIB was highest in the more deprived quintiles. There was a significant decrease in 30‐day case‐fatality from 10.1% in 2000 to 7.9% in 2015 ( P < 0.001), which was observed across all deprivation quintiles. Mean length of stay fell from 3.9 to 2.1 days. There was no difference in 30‐day case‐fatality or mean length of stay between patients presenting on weekdays or at weekends. Conclusions In this national study, we demonstrated that case‐fatality and mean length of stay after presentation with UGIB in Scotland has fallen over the past 16 years, despite a rise the in mean age of patients. There is a positive correlation between the incidence of UGIB and deprivation. We found no evidence of worse outcomes among patients presenting at weekends.

Etiology

Demographics

Upper Gastrointestinal Bleeding

Case fatality rate

10.1111/apt.16170

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Citations (9)

ORX volume 21 issue 3 Cover and Front matter

Oryx (1987)

Peter Scott Cbe Dsc E Asibey David Attenborough Cbe Frs

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Front cover

Content (measure theory)

10.1017/s0030605300026843

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Contents, Vol. 35, 1986

Digestion (1986)

W. E. W. Roediger Michael J. Lawson S.H. Nance Barbara Radcliffe Shoichiro Hirose

10.1159/000199366

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Outcomes Of Lumen Apposing Metal Stent Placement In Patients With Surgically Altered Anatomy: A Multicenter International Experience

Endoscopy International Open (2024)

Benedetto Mangiavillano Daryl Ramai Michel Kahaleh Amy Tyberg Haroon Shahid

Although outcomes of lumen-apposing metal stents (LAMS) placement in native anatomy have been reported, data on LAMS placement in surgically altered anatomy (SAA) are sparse. We aimed to assess outcomes of LAMS placement in patients with SAA for different indications.

Lumen (anatomy)

10.1055/a-2411-1814

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Citations (1)

Hypergastrinaemia and antral gastrin cell hyperplasia in the chronic gastric fistula rat

Regulatory Peptides (1984)

Chris Griffiths John Morris

10.1016/0167-0115(84)90113-7

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Endoscopic therapy for upper gastrointestinal bleeding: less is more?

Frontline Gastroenterology (2018)

Baldwin Po Man Yeung Carol Craig John Morris Andrew Christie Ram Kasthuri

An elderly patient with a known symptomatic oesophageal radiation stricture had endoscopic dilatation to 15 mm to good effect. The stricture developed as a consequence of radical chemoradiotherapy for unresectable lung cancer more than 7 years ago. Repeat biopsies did not reveal dysplasia or malignancy. Four months later, a CT was performed as part of lung cancer follow-up. It did not show evidence of cancer recurrence; however, a small asymptomatic mid-oesophageal perforation was identified. This was managed conservatively by nasojejunal feeding. Repeat CT with oral contrast showed no evidence of contrast extravasation. After multidisciplinary discussion, fibrin sealant …

Upper Gastrointestinal Bleeding

10.1136/flgastro-2017-100911

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Selective influences of oxytocin on the evaluative processing of social stimuli

Journal of Psychopharmacology (2010)

Greg J. Norman John T. Cacioppo John Morris Kate Karelina William B. Malarkey

The neuropeptide oxytocin has been implicated in a wide range of social processes, such as pair bonding, affiliation, and social judgments that may contribute to normal adjustment and psychiatric states. The present experimental study sought to elucidate potential underlying mechanisms by which oxytocin may impact social processes by examining the effects of intranasal oxytocin on basic evaluative processes. Subjects rated slide stimuli from the International Affective Picture System, varying across multiple categories (pleasant, neutral, unpleasant) and social content. Separate ratings for arousal and for the positive and negative components of valence were obtained in the context of a bivariate evaluative space model. Oxytocin did not have an independent significant effect on positivity or negativity ratings, but instead oxytocin treatment altered the interaction between these component processes for social, relative to non-social stimuli regardless of valence conditions. Specifically, oxytocin, relative to vehicle, significantly decreased arousal ratings to threatening human stimuli without altering ratings of threatening animal stimuli. These results indicate that oxytocin may exert its effects through dynamic alterations in the partially separable neural substrates mediating arousal as well as positive and negative evaluations of social stimuli.

Dyad

10.1177/0269881110367452

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Citations (92)

Sir Henry Halford, president of the Royal College of Physicians, with a note on his involvement in the exhumation of King Charles I

Postgraduate Medical Journal (2007)

John Morris

Abstract Henry Halford (formerly Vaughan) (1766–1844) was president of the Royal College of Physicians for an unprecedented 24 years. A successful physician, he had to resign his post at the Middlesex Hospital because of his growing private practice. He was physician to four reigning monarchs and had many famous patients including Geogiana Duchess of Devonshire in whom he correctly diagnosed a liver abscess when other physicians had failed. He was also involved in the exhumation of King Charles I, and the fourth cervical vertebra, through which the King had been executed, came into his possession.

Possession (linguistics)

10.1136/pgmj.2006.055848

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Crohn’s Disease in Jewish People – An Epidemiological Study in South-East Wales

Digestion (1986)

J F Mayberry Delyth Judd Howard Smart John Rhodes Brian Calcraft

The prevalence of Crohn's disease in the Jewish population of south-east Wales was established by a postal survey, review of case notes and a survey of Jewish congregations in the three synagogues of the area. The prevalence of Crohn's disease had been established in various earlier studies at 52/105. Seven Jewish patients were identified amongst a population of between 1,750 and 2,500. The prevalence ranged from 280 to 400/105 (95% confidence interval 120–862/105). There was no significant difference in prevalence between orthodox and reformed Jews. Jewish people are at a relative risk of developing Crohn's disease of 5.4–7.7 (95% confidence interval 2.3–17.2, p < 0.001), but the role of diet is yet to be established.

10.1159/000199374

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Citations (39)

Social interaction modulates autonomic, inflammatory, and depressive-like responses to cardiac arrest and cardiopulmonary resuscitation

Proceedings of the National Academy of Sciences (2010)

Greg J. Norman Ning Zhang John Morris Kate Karelina Gary G. Berntson

Psychological factors, including depression and social isolation, are important determinants of cardiovascular health. The current study uses a well-validated mouse model of cardiac arrest/cardiopulmonary resuscitation (CA/CPR) to examine the effect of social environment on several pathophysiological and behavioral responses to cerebral ischemia. Male experimental mice were either housed in pairs with an ovariectomized female or socially isolated for the duration of the experiment. Cardiac arrest increased the mRNA expression of the proinflammatory cytokines TNF-α, IL-1β, and IL-6, as well as the microglia marker MAC-1; expression of each of these factors, except IL-6, was further increased among socially isolated mice. Furthermore, socially isolated animals exposed to the CA/CPR procedure displayed significantly higher levels of neuronal cell death and microglia staining within the hippocampus at 7 d following surgery. Social isolation also exacerbated CA/CPR-induced depressive-like behavior and cardiac autonomic dysregulation. In the absence of ischemic damage, social environment had no significant effect on the expression of neuronal cell death, autonomic cardiac control, or behavior. Together, these data suggest that social factors influence the pathophysiological trajectory following cardiac arrest.

Proinflammatory cytokine

Pathophysiology

Depression

Social Isolation

10.1073/pnas.1007583107

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Citations (42)