Igor Tozzi di Angelo

Palacký University Olomouc

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Vlastimil Procházka

Palacký University Olomouc

Martin Holinka

Palacký University Olomouc

Jana Zapletalová

Palacký University Olomouc

Dušan Klos

Palacký University Olomouc

Ludmila Kazdová

Institute of Clinical and Experimental Medicine

Rostislav Večeřa

Palacký University Olomouc

Hana Malínská

Institute of Clinical and Experimental Medicine

R Havlík

University Hospital Olomouc

Martin Loveček

University Hospital Olomouc

Martin Poruba

Palacký University Olomouc

Cooperative Institutions

Palacký University Olomouc

University Hospital Olomouc

Ocní klinika

Institute of Molecular and Translational Medicine

Institute of Clinical and Experimental Medicine

Czech Academy of Sciences, Institute of Physiology

Charles University

Masaryk University

Czech University of Life Sciences Prague

University of Yamanashi

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Improvement bioavailability of silymarin ameliorates severe dyslipidemia associated with metabolic syndrome

Xenobiotica (2015)

Martin Poruba Ludmila Kazdová Olena Oliyarnyk Hana Malínská Zuzana Matušková

1. To compare the effectiveness of different drug forms of silymarin: standardized extract of silymarin (SS), micronized silymarin (MS) and silymarin in the form of phytosome (PS) on dyslipidemia and liver fat accumulation in a model of metabolic syndrome, in non-obese hereditary hypertriglyceridemic rats. The second aim of this study was to slightly uncover the silymarin action on enzymes and proteins involved in cholesterol metabolism and excretion.2. Silymarin administered to hereditary hypertriglyceridemic rats as dietary supplements (1%) for 4 weeks significantly lowered the plasma levels of triglycerides, total cholesterol and markedly increased HDL cholesterol level. Western blot analyses showed significant increase in the protein expression of CYP7A1 and CYP4A and increase in protein expression of selected ABC transporters. Silymarin in the form of phytosome and micronized silymarin were more effective forms of silymarin.3. These findings suggest that silymarin may favorably affect the metabolism of cholesterol and triglycerides in rats with metabolic syndrome. Raising HDL levels suggests potentially important anti-atherogenic effect of silymarin. The changes in expression of cytochromes P450 and ABC transporters involved in cholesterol metabolism and excretion could be partially responsible for the hypolipidemic effect of silymarin.

Dyslipidemia

10.3109/00498254.2015.1010633

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The significance of endo-ultrasonography in the preoperative management of patients with (early) pancreatic cancer

Pancreatology (2012)

Martin Loveček Pavel Skalický Dušan Klos Igor Tozzi di Angelo Martin Kliment

10.1016/j.pan.2012.11.086

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ENDOSONOGRAPHY VERSUS ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY IN DIAGNOSING EXTRAHEPATIC BILIARY OBSTRUCTION

Biomedical Papers (2011)

Igor Tozzi di Angelo Vlastimil Procházka Martin Holinka Jana Zapletalová

Objective: Endosonography (EUS) performed prior to endoscopic retrograde cholangiopancreatography (ERCP) or surgery in patients with a low to moderate probability of choledocholithiasis can reduce morbidity, mortality and costs. Aims: This study aimed at evaluating the sensitivity and specificity of EUS and transabdominal ultrasonography (TUS) compared to ERCP in a cohort of 100 patients diagnosed with extrahepatic biliary obstruction. Methods: There were four working groups. The first group processed the initial data including history, physical examination and assessment of laboratory markers of cholestasis. The second group examined TUS. The third group examined the pancreas and biliary tree using EUS, always prior to ERCP. The fourth working group carried out ERCP. Results: The sensitivity and accuracy of EUS in the diagnosis of common bile duct dilatation were 84% and 83%, respectively, i.e. significantly higher (p=0.0001) than TUS (46% and 66%, respectively). The specificities of methods (82%, 91%) were not significantly different (p=0.218). The sensitivity and accuracy of EUS in the diagnosis of pathological content of the common bile duct were 88% and 92%, respectively, i.e. significantly higher (p

Endoscopic ultrasonography

10.5507/bp.2011.044

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Mitochondrial Changes in Adenocarcinoma of the Pancreas

Ultrastructural Pathology (2013)

Radko Novotný Jiří Ehrmann Igor Tozzi di Angelo Vlastimil Procházka Dušan Klos

The aim of our study was to analyse the mitochondrial ultrastructure in primary ductal adenocarcinomas of the pancreas and to compare it with normal pancreatic cells. 52 samples of adenocarcinoma of the pancreas obtained by surgical resection or by endosonographic biopsy were examined. Compared to normal mitochondrial ultrastructure in non-tumorous cells, the mitochondria in cancer cells had a dense matrix and condensed configuration or with lucent-swelling matrix associated with disarrangement and distortion of cristae and partial or total cristolysis. Functionally, these structural alterations presume the presence of hypoxia-tolerant and hypoxia-sensitive cancer cells.

Hypoxia

Mitochondrial matrix

10.3109/01913123.2013.788306

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Tu1523 Multicenter Comparative Study of Detection and Evaluation of the Size of Oesophageal Varices With the Use of 12 and 20mhz Frequency Radial Endosonography vs Oesophagogastroduodenoscopy

Gastrointestinal Endoscopy (2012)

Igor Tozzi di Angelo Vlastimil Procházka Martin Holinka Ivona ŠImková Radan Brůha

Gastric varices

Gastrointestinal bleeding

10.1016/j.gie.2012.03.1169

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T1499: Sensitivity, Specificity and Predictive Value of Choledocholithiasis by EUS and ERCP

Gastrointestinal Endoscopy (2010)

Igor Tozzi di Angelo Vlastimil Procházka Martin Holinka M Konĕcný Jana Zapletalová

Endoscopic ultrasonography

10.1016/j.gie.2010.03.712

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Citations (2)

Význam radiální endosonografie v diferenciální diagnostice obstrukce žlučových cest

Igor Tozzi di Angelo

Pro nizkou senzitivitu i specificitu ma TUS v diagnostice obstrukce žlucových cest jen orientacni význam. Zlatým standardem pro diagnostiku i lecbu choledocholitiazy je ERCP. EUS provedena před ERCP nebo operaci u nemocných s nizkou až středni pravděpodobnosti choledocholitiazy snižuje rizika, morbiditu i naklady

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Positive Effects of Different Drug Forms of Silybin in the Treatment of Metabolic Syndrome

Physiological Research (2015)

Martin Poruba Zuzana Matušková Ludmila Kazdová Olena Oliyarnyk Hana Malínská

Silymarin and silybin are widely used for their hepatoprotective properties. Our previous studies confirm positive effect of silymarin on lipoprotein profile and lipid homeostasis. Advanced drug forms may improve the bioavailability of these compounds. In this study, we investigate the effects of silybin in different drug forms (standardized silybin, micronized silybin, and silybin in form of phytosomes) on dyslipidemia and glucose metabolism in hereditary hypertriglyceridemic (HHTg) rats. Male HHTg rats were divided into four groups of seven animals and were fed by experimental diets. Silybin significantly decreased serum level of triglycerides in groups of rats fed by standardized silybin and silybin in form of phytosomes compared to control group. Results show that silybin did not affect the total cholesterol level, but significantly increased the levels of HDL cholesterol in all groups of animals. Silybin in a standardized form had the highest hypotriglyceridemic effect. On the other hand, the micronized form has caused the highest increase of protective HDL and most significantly decreased glucose and insulin levels. Our results suggest that silybin is probably responsible for some positive properties of silymarin. Subsequent dose-dependent studies of silybin action may reveal the intensity of its positive effects on lipid and glucose parameters.

Dyslipidemia

10.33549/physiolres.933235

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Citations (16)