Jiyao Tang

Wenzhou Medical University

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Yanlin Zhu

Harbin Engineering University

Xiaosong Ben

Soochow University

Run Yan

Songjiang District Central Hospital

M.-T. Wang

Shanxi Medical University

Shaojun Du

University of Maryland, Baltimore

Ermei Lu

Wenzhou Medical University

Zimu Cai

Shanghai Jiao Tong University

Liting Chen

China Medical University

S.-L. Chen

Guangdong Academy of Medical Sciences

Z. Xie

Meizhou City People's Hospital

Cooperative Institutions

Wenzhou Medical University

Guangdong General Hospital

Zhejiang Lab

Guangdong Academy of Medical Sciences

Guangdong Provincial People's Hospital

Shanghai Jiao Tong University

Songjiang District Central Hospital

Southern Medical University

First Affiliated Hospital of Wenzhou Medical University

Zhejiang University

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NIPSNAP3A regulates cellular homeostasis by modulating mitochondrial dynamics

Gene (2024)

Run Yan Liting Chen Zimu Cai Jiyao Tang Yanlin Zhu

Homeostasis

Dynamics

10.1016/j.gene.2024.148976

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Prognostic significance of cyclinD1 amplification and the co-alteration of cyclinD1/pRb/ppRb in patients with esophageal squamous cell carcinoma

Diseases of the Esophagus (2011)

M.-T. Wang G. Chen S.-J. An Zhendong Chen Zhimin Huang

CyclinD1/pRb/ppRb is one of the most important pathways regulating the cell cycle, and related with the development of many cancers. However, the co-alteration of CyclinD1/pRb/ppRb in esophageal squamous cell carcinomas is less understood. This study aims to analyze the combined prognostic significance of cyclinD1 (CCND1) DNA amplification and the co-alteration of CCND1/pRb/ppRB in patients with esophageal squamous cell carcinoma. CCND1 DNA amplification and the protein expression of CCND1, pRb, and ppRb on 100 tumor specimens and 11 normal tissues were detected using real-time quantitative reverse transcription polymerase chain reaction and immunohistochemistry, respectively. Their prognosis significance was analyzed by Kaplan–Meier method. We found that 41% of the patients had CCND1 DNA amplification, which had a short survival time compared with the patients without CCND1 amplification (25.63 months vs. not reached, P = 0.007). The patients with the co-alternation of CCND1+/pRb–/ppRb+ protein expression levels have a poorer overall survival than the others (11.4 vs. 43.4 months, P = 0.001). Cox regression analysis showed that the co-alternation of CCND1/pRb/ppRb and CyclinD1 amplification were the two most independent prognosis factors of patients with esophageal cancer. These findings suggested that CCND1 amplification and co-alternation of CCND1+/pRb–/ppRb+ may play a crucial role in the prognostic evaluation of patients with esophageal cancer, and the patients with CCND1+/pRb–/ppRb+ have the worst prognosis in all the patients. The results also indicated that the patients with CCND1 amplification or co-alternation of CyclinD1+/pRb–/ppRb+ might be the preponderant people for therapy targeting the CCND1/pRb/ppRb pathway in the future.

Clinical Significance

10.1111/j.1442-2050.2011.01291.x

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A cryo-shocked M2 macrophages based treatment strategy promoting repair of spinal cord injury via immunomodulation and axonal regeneration effects

Journal of Nanobiotechnology (2025)

Ermei Lu Kecheng Zhou Jiansen Miao Yanlin Zhu Jiyao Tang

Recovery from spinal cord injury (SCI) is often impeded by neuroinflammation, scar formation, and limited axonal regeneration. To tackle these issues, we developed an innovative biomimetic drug delivery system using liquid nitrogen-treated M2 macrophages (LNT M2) which internalized paclitaxel (PTX) nanoparticles beforehand. These were incorporated into a gelatin methacryloyl (GelMA) scaffold, creating a multifunctional, injectable treatment for single-dose administration. The LNT M2 inherited the inflammatory factor/chemokine receptors from the living M2 macrophages and thus possessing significant inflammatory neutralizing effect. In addition, the scaffold provides slow, sustained release of PTX, promoting axonal regeneration and suppressing scar formation in SCI rats. The LNT M2-based dual-functional scaffold significantly enhances motor function, reduces neuroinflammation, and accelerates axonal regeneration by modulating the inflammatory microenvironment and preventing the formation of glial and fibrotic scars. This approach combines the regenerative effects of low-dose PTX with the immunoregulatory properties of LNT M2, leading to remarkable neurological recovery in SCI rats. Moreover, the scaffold's straightforward preparation, ease of standardization, and "ready-to-use" nature make it a promising candidate for acute SCI intervention and future clinical applications.

10.1186/s12951-024-03018-x

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