The aim of this study is to investigate whether medetomidine (MED) and tiletamine/zolazepam (ZT) combination in dogs provide the sufficient analgesia during the period of the stage of surgical anesthesia determined by the response to the noxious stimuli, which were evaluated by the change of electroencephalogram (EEG) and hemodynamic values. Seven clinically healthy, adult beagle dogs were used. They were used repeatedly at interval of a week, according to a randomized design. This study had 2 experimental groups. In Group 1, dogs received 30 ㎍/㎏ of medetomidine and 10 ㎎/㎏ of tiletamine/zolazepam. Both drugs were administered intramuscularly. In Group 2, dogs were medicated with the same method as in Group 1, except the pedal withdrawal reflex test was done. In Group 2, interdigital regions were grasped with a mosquito forceps for 30 seconds, every 5 min from 10 min to 45 min after ZT injection. During all recording stages, the power for each band, mean arterial pressure and heart rates were calculated. On EEG, no significant changes were observed between groups. Although mean arterial pressure and heart rate were increased 10 min after ZT injection, no significant differences were observed between groups. In conclusion, the MED and ZT anesthesia in dogs are seemed to provide a satisfactory analgesic effect during the period of surgical anesthesia based on EEG with pedal withdrawal reflex test.
This study was performed to determine the minimum dose of Poloxamer/Sodium alginate (PX/SA) mixture on preventing intraperitoneal adhesions to evaluate organ toxicity. Twenty five healthy adult mongrel dogs (weighing 4.68 ± 1.67 ㎏) were divided into five experimental groups composed of five dogs respectively; negative control group (NC, non-treated), positive control group (PC, 2% carboxymethyl chitosan solution treated), and experiment 1 group (E1, 0.25 ㎖ PX/SA mixture of abraded area), experiment 2 group (E2, 0.5 ㎖ PX/SA mixture of abraded area), experiment 3 group (E3, 1.0 ㎖ PX/SA mixture of abraded area). Venous blood specimens were collected from all experimental animals for hematologic and biochemical analysis: WBC, fibrinogen, AST, ALT, ALP, BUN and creatinine. The anti-adhesion effect was evaluated using a serosa abrasion model. The denuded ileum was coated with PX/SA mixture, carboxymethyl chitosan solution or neither. The tensile strength of the adhesion site was evaluated with a tensiometer. For histopathological examination, tissue samples of the liver and kidney were collected from all dogs. According to the results, the frequency and tensile strength values for adhesion separation in PX/SA group were significantly lower than those in negative control group (p ＜ 0.05). In E2 group, the tensile strength was significantly decreased in consideration of PX/SA dose. The values of AST, ALT, ALP, BUN and creatinine of the control and the experimental groups showed no statistical differences. No obvious microscopic differences were noted among tissue sections obtained from all groups. The results suggest that PX/SA mixture may be effective on reducing peritoneal adhesion formation in dog and that 0.5 ㎖ PX/SA mixture of abraded area is most effective dose. Moreover, PX/SA mixture was considered not to have toxicity for the liver and the kidney.
This study showed the possibility of using a sub-terahertz (THz) traveling-wave tube (TWT) via measuring the transmission characteristics and TWT performance of the circuit by applying X-ray LIGA, a micro-fabrication process, to the interaction circuit. The applied circuit type, an E-bend folded waveguide, is a simple structure most suitable for lithography. A total of three applied frequencies were used the W-band, G-band, and 850 GHz. Among the manufactured circuits, the W-band circuit was applied to the TWT, one of the vacuum electronics devices (VEDs). This was done to prove the manufacturing accuracy of the circuit by comparing the nonlinear characteristics of the circuit with the prediction results. Through such testing, the small signal gain was measured as 13 ± 2 dB under the conditions of 13.96-kV and 24.2-mA electron beam energy. The frequency bandwidth was extremely wide, about 9 GHz, and showed similar characteristics to the simulation predictions. The maximum output of the device was obtained up to 1 W or more at 87.12 GHz by slightly increasing the beam current. These characteristic achievements showed the suitability of the TWT for very small circuits fabricated using the X-ray LIGA process, further suggesting the applicability of other sub-THz bands.
Sung-Ho Yun, Jihee Park, Jeongkyu Park, Manseop Kim, Dalwon Kim, Moon-Yong Song, Gyoo-Il Kang, Won-Koo Hwang, Sae-Kwang Ku, Kwang-Ho Jang and Young-Sam Kwon. J Vet Clin 2015;32:404-9. https://doi.org/10.17555/jvc.2015.10.32.5.404
Though development of diverse and highly value-added commodities in Artemisia Iwayomogi, we can expect such effects as procurement of secure farm's production bases and promotion of consumer's demands. Thus, as a first step for development of funtional foods of Artemisia Iwayomogi, solids yield, physical properties and scopoletin contents which is main component of Artemisia Iwayomogi, were investigated according to extration solvents and temperatures. The main result of this experiment were as following: solid yield in 50% ethanol extracts showed higher than those of water extracts at the same temperature. In condition of 50% ethanol extracts, solid yield, degree of browing and scopoletin contents showed increasing, but turbidities which mean transmittance(%T) showed decreasing sa temperature rise. In water extracts, pH values showed increasing as temperature rise.
Tracheal ultrasonography was performed to measure the width of the tracheal ring shadow and to assess the clinical relevance of these measurements for identifying tracheal collapse.The first tracheal ring width (FTRW) and thoracic inlet tracheal ring width (TITRW) were measured on both expiration and inspiration.The mean of the FTRW width (129 dogs) was greater in expiration (10.97 ± 1.02 mm, p = 0.001) than that in inspiration (9.86 ± 1.03 mm).For 51 normal dogs, the mean of the TITRW width was greater in expiration (9.05 ± 1.52 mm, p = 0.001) than in inspiration (8.02 ± 1.43 mm).For 78 tracheal collapse dogs, the mean of the TITRW width was greater in expiration (15.89 ± 1.01 mm, p = 0.001) than in inspiration (14.85 ± 1.17 mm).The TITRW/FTRW ratio of the normal dogs was higher (p = 0.001) in expiration (0.81 ± 0.09) than that in inspiration (0.79 ± 0.10).When compared between the normal and tracheal collapse dogs, the TITRW/FTRW ratio was also increased (p = 0.001) both in expiration (1.54 ± 0.09) and inspiration (1.47 ± 0.08), respectively.Based on these results, the cutoff level of the TITRW/FTRW ratio was statistically analyzed according to the receiver operating characteristic curve and it could be set at 1.16 in expiration and at 1.13 in inspiration.We have demonstrated that tracheal ultrasonography is a useful technique for the evaluation of tracheal collapse and it can be a supportive tool together with the radiographic findings for making the correct diagnosis.
'%3e%3cg id='b'%3e%3cpath id='a' stroke='%23000' stroke-width='2' d='M-6-25H6m-12 3H6m-12 3H6'/%3e%3cuse xlink:href='%23a' y='44'/%3e%3c/g%3e%3cpath stroke='%23fff' d='M0 17v10'/%3e%3ccircle r='12' fill='%23cd2e3a'/%3e%3cpath fill='%230047a0' d='M0-12A6 6 0 0 0 0 0a6 6 0 0 1 0 12 12 12 0 0 1 0-24z'/%3e%3c/g%3e%3cg transform='rotate(-123.69)'%3e%3cuse xlink:href='%23b'/%3e%3cpath stroke='%23fff' d='M0-23.5v3M0 17v3.5m0 3v3'/%3e%3c/g%3e%3c/svg%3e)